Thromboembolic Disorders

Understanding in-hospital mortality after stroke in pediatric patients

April 25, 2018

Findings suggested that the rate of in-hospital mortality after pediatric stroke was 1.5% for neonates and 3.1% in children/adolescents. The authors also found that the strongest risk factors for mortality were congenital heart disease and stroke that involved both anterior and posterior circulation.

Carvedilol vs Metoprolol: Mortality Risk Examined Among Hemodialysis Patients

By April 18, 2018

Results showed that compared to metoprolol, those who initiated carvedilol had a greater all-cause (HR, 1.08; 95% CI,1.02-1.16) and cardiovascular mortality (HR, 1.18; 95% CI, 1.08-1.29).

Review: Lowest Mortality Risk Seen With ≤100g Alcohol/Week

April 13, 2018

"These data support limits for alcohol consumption that are lower than those recommended in most current guidelines," the authors write.

Coffee Consumption Cuts Coronary Artery Calcification

April 05, 2018

The researchers identified significant inverse associations between coffee consumption (more than 3 cups/day) and CAC ≥100 (odds ratio, 0.33 for more than three cups/day).

Outcomes-Based Pricing Doesn't Cut Costs of PCSK9 Inhibitors

April 03, 2018

"Although outcomes-based pricing may have a role in other settings, our analysis of its application to PCSK9 inhibitors - effective preventive medications with a high price tag - shows the potential limitation of this approach for high-cost preventive therapies," the authors write.

Lower Thromboembolic Risk With New A-Fib After CABG Versus NVAF

March 29, 2018

The researchers found that oral anticoagulation therapy was initiated within 30 days post-discharge in 8.4 and 42.9% of those with POAF and NVAF, respectively.

What Areas of Health are Affected Most Post-Ischemic Stroke?

March 29, 2018

Patients with higher modified Rankin Scale (mRS) levels had worse scores, though the association between scores and mRS level varied. Physical function, satisfaction with social roles, and executive function were the most affected domains.

Tresiba Label Updated With Data on Severe Hypoglycemia, CV Outcomes

By March 26, 2018

The Tresiba label was updated to reflect safety outcomes from the DEVOTE trial.

Environmental Lead Exposure May Increase CVD Mortality Risk

March 16, 2018

Environmental lead exposure tied to all-cause, cardiovascular disease, ischemic heart disease mortality

Comparative Safety of NSAIDs Among Clopidogrel Users Investigated

By March 15, 2018

Using Medicaid claims from 5 states (1999-2010) and Medicare claims for dual-enrollees, study authors analyzed the first concomitant use of clopidogrel and 1 of 10 selected NSAIDs (ibuprofen, celecoxib, naproxen, rofecoxib, meloxicam, diclofenac, indomethacin, valdecoxib, nabumetone, etodolac) after a 1-year baseline period.

Cocaine/Marijuana May Up Mortality in Younger MI Patients

March 13, 2018

Cocaine and/or marijuana use present in 10.7% of myocardial infarction patients age ≤50 years

Dabigatran Cuts Risk of Major CV Complications in Patients With MINS

By March 13, 2018

The primary efficacy outcome was the combined rate of death from a cardiovascular cause, heart attack, stroke due to inadequate blood supply, blood clots or amputation due to cardiovascular disease.

Alirocumab Tied to Reduced Risk of CV Events, Death in High-Risk Patients

By March 12, 2018

The ODYSSEY Outcomes trial (N=18,924) evaluated the effect of alirocumab on the occurrence of MACE in patients who had an ACS between 1-12 months prior to trial enrollment, and who were already taking maximally-tolerated statins (atorvastatin or rosuvastatin).

Ticagrelor vs Clopidogrel: TIMI Major Bleed Rates Compared Post-Fibrinolysis

By March 12, 2018

After 30 days of treatment the analysis found that major bleeding - the most common complication with blood thinners - occurred at the same level (0.7%) for patients in both treatment groups

Aspirin comparable to rivaroxaban for extended venous thromboembolism prophylaxis following arthroplasty

February 23, 2018

Patients initially treated with rivaroxaban following total knee or hip arthroplasty experienced similar rates of venous thromboembolism (VTE) regardless of continued rivaroxaban use or switching to aspirin for extended VTE prophylaxis.

Thrombectomy improves functional outcomes for imaging screened patients 6 to 16 hours after stroke

February 23, 2018

Patients presenting with ischemic stroke 6 to 16 hours after they were last known to be well had improved functional outcomes at 90 days if treated with thrombectomy and medical therapy compared to medical therapy alone.

FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients

By February 22, 2018

The Agency is asking healthcare professionals to use caution before prescribing the antibiotic to this patient population.

Cardiovascular Risk Compared Among COX-2 Selective, Nonselective NSAIDs

By February 22, 2018

Results showed the crude hazard ratio (HR) of major cardiovascular events was 1.99 (95% CI, 1.28-3.09) for COX-2 vs. nonselective NSAIDs.

Retinal Images Can Be Used to Predict CV Risk, Says Google Study

By February 22, 2018

The model used retinal images to predict cardiovascular risk.

Treatment Window for Using Clot Retrieval Device Now Expanded

By February 15, 2018

The Trevo device is inserted via a catheter into the blood vessel to the site of the clot. The end portion of the device expands (up to 3-6mm diameter) and grips the clot, allowing the physician to pull it back through the vessel along with the device.

FDA: New Clinical Decision Support Tool Helps ID Stroke Sooner

By February 14, 2018

The Viz.AI Contact application is a computer-aided triage software that uses an artificial intelligence algorithm to analyze images for indicators associated with a stroke.

Quality of care for transient ischemic attack and minor stroke vary across country

February 13, 2018

In this study about quality of care for patients with TIA or minor stroke, there was substantial variation in adherence to guidelines for patients treated at Veteran's Affairs (VA) hospitals across the country.

Safety, Efficacy of Direct Oral Anticoagulants + Antiplatelets Evaluated After ACS

February 12, 2018

Pronounced benefit for patients with STEMI, but no significant effect for patients with NSTE-ACS

Preoperatively diagnosed patent foramen ovale linked to increased perioperative stroke risk

February 08, 2018

A preoperatively diagnosed patent foramen ovale was associated with an increased risk of stroke within 30 days of non-cardiac surgery. With Evidence Rating Level: 2 (Good).

Women May Experience Worse Stroke Outcomes Than Men

February 08, 2018

The researchers found that in 8 studies which included ischemic and hemorrhagic stroke, women had worse outcomes than men, with significantly lower odds of good outcome or increased odds of poor outcome.

PFO Could Increase Stroke Risk Following Non-Cardiac Surgery

February 07, 2018

There were 850 ischemic strokes (0.6%) within 30 days of surgery: 3.2 and 0.5% among patients with and without PFO, respectively.

Hand Breaking May Be Best for Splitting Aspirin Tablets

February 02, 2018

There was a statistically significantly smaller loss of mass (mg) for the hand (P<0.001) and the PillTool (P<0.001) versus the knife and the Pilomat.

Migraines and Cardiovascular Disease: What's the Link?

February 01, 2018

There were positive associations for migraine with myocardial infarction, ischemic stroke and hemorrhagic stroke, venous thromboembolism, and atrial fibrillation or flutter.

Should all Syncope Patients Undergo Evaluation for Pulmonary Embolism?

January 30, 2018

At 90 days, the prevalence of venous thromboembolism varied from 0.3 to 1.37% for all patients and from 0.75 to 3.86% for hospitalized patients.

Stroke, Major Bleed Risk Compared Among Novel Oral Anticoagulants

By January 26, 2018

The study analyzed data from NVAF patients newly initiating treatment with dabigatran, rivaroxaban or apixaban.