Thromboembolic Disorders

Patient VTE Prophylaxis Uptake Following Nurse Education

August 18, 2017

After the online training, the number of patients who refused to take prescribed VTE prophylaxis dropped from 12.4 to 11.1%, the investigators found.

Cancer, CV Risks Examined for Vaginal Estrogen Tx in Postmenopausal Women

By August 16, 2017

The data showed women with an intact uterus did not have a significantly different risk of stroke, invasive breast cancer, colorectal cancer, endometrial cancer, and pulmonary embolism/deep vein thrombosis (PE/DVT) between those who used vaginal estrogen and those who did not.

Reduced Risk of Intraocular Bleeding with Novel Oral Anticoagulants

By August 14, 2017

The main outcomes and measures were intraocular bleeding events and associated risk ratio for NOACs, compared with warfarin.

Statin Rx Given to Less than Half of Stroke Patients at Discharge

August 03, 2017

The researchers restricted analyses to 323 of the 666 patients with incident stroke who were not statin users at the time of admission and had no history of atrial fibrillation.

Repatha sBLA Under Priority Review for MACE Risk Reduction

By July 28, 2017

Results showed that the evolocumab group had a statistically significant 15% reduction (P<0.001) in the risk of extended MACE composite (primary) endpoint - which included hospitalization for unstable angina, coronary revascularization, heart attack, stroke or cardiovascular death - compared to placebo group.

Smoking Cessation Med Use Low in Older Patients After MI

July 21, 2017

Ninety-seven percent of smoking patients with MI received counseling, but few have SCM use

Idarucizumab Effective for Dabigatran Reversal in Emergency Situations

July 13, 2017

Effective for dabigatran reversal among patients with uncontrolled bleeding, undergoing urgent surgery

USPSTF: Recommendations Issued on Lifestyle Counseling for Healthy Patients

July 12, 2017

USPSTF urges doctors to talk to low-risk, in addition to high-risk, adults about lifestyle

Vasodilators May Help Prevent Clots, Stenosis with Stents

July 12, 2017

"If clinical trials show that sildenafil reduces restenosis after stent placement, it could be used in the clinical setting right away because the drug is already used in the real world for other purposes," said the lead author Han-Mo Yang.

The Rate of At-Home Medication Errors Has Doubled

July 11, 2017

The rate of serious medication errors rose from 1.09 for every 100,000 Americans in 2000 to 2.28 per 100,000 by 2012.

Cardiovascular, Cerebrovascular Risk Examined for LABA/LAMA in COPD

By July 07, 2017

Overall results demonstrated that for the LABA/LAMA cohort cardiovascular event frequency was 2.11% compared to 3.41% in the LABA/ICS cohort.

Food Type, Timing Has No Clinically Relevant Impact on Rivaroxaban

By July 06, 2017

Currently, the prescribing information recommends 20mg once daily with an evening meal for the AF indication, and 15mg twice daily with food for 21 days, followed by 20mg once daily with food for the remainder of treatment for the DVT/PE indications.

CDC: 'Health of the Nation' 40th Annual Report Published

June 30, 2017

Report includes trends of data for past 40 years, with increase in life expectancy, drop in infant mortality

Metformin Shows Promise as Post-Ischemic Conditioning Agent

June 29, 2017

The researchers found that postconditioning with metformin at a concentration of 2.5 µg/mL effectively maintained cell viability and membrane stability of H9C2 cardiomyoblast cells after ischemic injury.

Review Queries Efficacy of Antithrombotic Tx in Thrombocythemia

June 28, 2017

With antiplatelet therapy versus none, the reported relative risks for thrombosis, any bleeding, and major bleeding ranged from 0.26 to 3.48, 0.48 to 11.04, and 0.48 to 5.17, respectively.

Does Niacin Therapy Prevent Cardiovascular Disease Events?

By June 28, 2017

Niacin (nicotinic acid) decreases LDL cholesterol and triglycerides and increases HDL cholesterol levels. However, its benefits are "controversial," when it comes to reducing cardiovascular events.

FDA to Review Lower Dose Xarelto for Recurrent VTE Risk Reduction

By June 28, 2017

Both doses of Xarelto (10mg and 20mg) were superior to aspirin (100mg) in lowering the risk of recurrent VTE after ≥6 months of standard anticoagulation.

Novel CETP Inhibitor Shows Coronary Improvements in Phase 3 Study

By June 27, 2017

The full results of the REVEAL trial will be announced at the European Society of Cardiology meeting on August 29.

Bevyxxa Approved for Prophylaxis of Venous Thromboembolism

By June 23, 2017

The study examined efficacy in 7,441 patients according to a composite outcome score consisting of either the occurrence of asymptomatic or symptomatic proximal deep vein thrombosis (DVT), non-fatal pulmonary embolism (PE), or VTE-related death

Frequency, Outcomes of Off-Label TAVR Procedures in the U.S.

June 22, 2017

Researchers examined patterns and adverse outcomes of off-label use of TAVR, defined as TAVR in patients with known bicuspid valve, moderate aortic stenosis, severe mitral regurgitation, severe aortic regurgitation, or subaortic stenosis, in U.S. clinical practice.

Vitamin K Antagonist Shows Protective Benefits in A-Fib

June 19, 2017

The researchers found that the associated risk of MI was increased for ASA and dual therapy relative to the VKA-treated group (incidence rate ratios [IRR], 1.54 and 1.22, respectively).

PPIs May Benefit Older Patients on Antiplatelet Therapy

June 15, 2017

Research suggests proton-pump inhibitors should be co-prescribed in patients age 75 years

Efficacy of Traditional Chinese Medicine Examined for CVD Prevention

June 13, 2017

For patients who can't tolerate or afford hypertension medications, the research suggested some herbal alternatives: tiankuijiangya, zhongfujiangya, jiangyabao, and jiangya.

Empagliflozin to Be Investigated in Chronic Kidney Disease

By June 12, 2017

In addition, the companies are conducting other mechanistic studies that will evaluate the potential mechanisms by which empagliflozin may affect renal outcomes in patients with CKD.

Anticoagulant Recalled Due to Incorrect Tablet Strength in Bottle

By June 08, 2017

The recall is specific to Eliquis 5mg Tablets (60-count bottle) Lot# HN0063 with expiration date of September 2019.

Dosing Errors Common with Certain Blood-Thinning Medications

June 06, 2017

Study of newer medications finds 16 percent receive too much or too little

Recommendations for Handling In-Flight Cardiac Arrest Proposed

By June 05, 2017

Emergency equipment should be available and its location should be mentioned in the pre-flight safety announcement.

Anticoagulation During Pregnancy Linked to Distinct Maternal, Fetal Risks

June 02, 2017

VKA, LMWH tied to lowest risk of adverse maternal, fetal outcomes, respectively

Do &#946;-Blockers Reduce Death Risk in Acute MI without Heart Failure?

June 01, 2017

No significant difference in mortality for MI patients without HF, LVSD with, without -blocker use

FDA to Review Cardiovascular Safety Data for Tresiba

By May 31, 2017

The long-term, multicenter, multinational, randomized, double-blind, parallel group, event-driven trial was conducted to confirm the cardiovascular safety of Tresiba vs. insulin glargine U-100.