Thromboembolic Disorders

No New Concerns With Rivaroxaban, According to FDA Mini-Sentinel Assessment

By January 16, 2018

The FDA analysis evaluated the safety of Xarelto in people with nonvalvular atrial fibrillation who initiated Xarelto or warfarin from November 2011 to April 2015.

Device closure for patent foramen ovale decreases recurrent stroke risk compared to medical therapy alone

January 16, 2018

Transcatheter device closure for patent foramen ovale (PFO) decreased recurrent stroke risk compared to medical therapy alone.

Thrombosis Risk Examined in Myeloproliferative Neoplasms

January 16, 2018

The researchers found that, compared with control participants, for patients with MPNs, the hazard ratios for arterial thrombosis were 3.0, 2.0, and 1.5 at 3 months, 1 year, and 5 years, respectively.

Recall: Clopidogrel Bottles May Contain Simvastatin Tablets

By January 10, 2018

International Laboratories, LLC is notifying distributors and customers by letter and is arranging for return of all recalled products.

Delta CHA<sub>2</sub>DS<sub>2</sub>-VASc May Forecast Stroke Likelihood More Accurately

January 09, 2018

The Delta CHA2DS2-VASc score significantly better predicted ischemic stroke compared to baseline or follow-up CHA2DS2-VASc scores

Are Patients With ITP at Increased Risk for Cardiovascular Disease?

January 09, 2018

The elevated risk of developing CVD in the ITP cohort (adjusted incidence rate ratio [IRR], 1.38) remained even after a sensitivity analysis which included only incident cases of ITP.

Survival in Patients With Severe Aortic Stenosis Impacted by LVEF

January 05, 2018

Compared with LVEF ≥70%, LVEF <50% and 50 to 59%, but not 60 to 69%, were independently associated with poorer outcomes in the conservative group.

Thrombectomy between 6 and 24 hours after acute stroke reduces disability: The DAWN trial

January 04, 2018

Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between stroke symptoms and infarct volume results in better disability outcomes compared to standard care alone.

Systemic atherosclerosis linked with intracranial atherosclerotic disease-related stroke and worse prognosis

January 04, 2018

In patients with stroke who had intracranial atherosclerotic disease (ICAD), atherosclerotic disease in other vascular beds was more common including the aortic arch and coronary artery disease.

New LABA, LAMA Use May Increase Cardiovascular Disease Risk in COPD

January 04, 2018

New use of long-acting 2-agonists, antimuscarinic antagonists tied to higher CVD risk in first 30 days

Reduced mortality with culprit-lesion-only percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock

January 01, 2018

In patients with acute myocardial infarction (MI) with cardiogenic shock and multivessel coronary disease, culprit-lesion-only percutaneous coronary intervention (PCI) had a lower risk of 30-day mortality compared to multivessel PCI.

Smoking Cessation Drug Linked to Increased Risk of Cardiovascular Events

By December 20, 2017

The researchers analyzed the medical records of 56,851 new users of varenicline.

FDA Approves Oral Solution Formulation of Valsartan

By December 20, 2017

First approved oral liquid dosage form of the angiotensin II receptor blocker valsartan.

Ginkgo Biloba Plus Aspirin May Alleviate Cognitive Deficits After Stroke

December 19, 2017

The researchers found that, compared with controls, patients in the GBE group had a marked deceleration in the decline in Montreal Cognitive Assessment scores at 30 days (−2.77±0.21 versus −1.99±0.23; P=0.0116).

Many Without Cardiovascular Risk Factors Have Atherosclerosis

December 13, 2017

LDL-C independently associated with the presence and extent of atherosclerosis

Efficacy of Edoxaban Investigated for CA-Linked Venous Thromboembolism

December 13, 2017

The researchers found that a primary-outcome event occurred in 12.8 and 13.5% of patients in the edoxaban and dalteparin groups, respectively (HR, 0.97; 95% CI, 0.70 to 1.36; P=0.006 for noninferiority; P= 0.87 for superiority).

Xarelto sNDA Submitted for Two New Vascular Indications

By December 11, 2017

For this group the risk of stroke was reduced by 42% (HR 0.58; 95% CI, 0.44-0.76; P<0.001), CV death by 22% (HR 0.78; 95% CI, 0.64-0.96; P=0.02) and heart attack by 14% (HR 0.86; 95% CI, 0.70-1.05; P=0.14).

RAS Inhibitor Use May Cut Risk of MI in Rheumatoid Arthritis Patients

By December 08, 2017

The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) was associated with a reduced risk of myocardial infarction (MI) among patients with rheumatoid arthritis (RA).

Should Antithrombotics Be Stopped Before Wide-Awake CTR Surgery?

December 05, 2017

Ninety-three of the 99 patients taking AT medication continued their normal regimen through surgery and were included in the analysis.

First PCSK9 Inhibitor Gets FDA Approval for MI, Stroke Prevention

By December 04, 2017

Repatha reduced the risk of heart attack by 27%, the risk of stroke by 21% and the risk of coronary revascularization by 22%.

ACC: New Guidance on Managing Bleeding in Patients on Oral Anticoagulants

December 04, 2017

At each step, patient specific factors should be considered.

Warfarin Stability Examined After Transfer to Dose Administration Aids

December 01, 2017

"Repackaging of warfarin sodium tablets into DAAs does not affect the chemical stability," the authors wrote.

Comparison of Oral Anticoagulants for Preventing Stroke in AF

By November 28, 2017

The greatest risk reduction of stroke or systemic embolism was seen with dabigatran 150mg twice daily (odds ratio [OR] 0.65, 95% CI: 0.52-0.81), followed by apixaban 5mg twice daily (OR 0.79, 95% CI: 0.66-0.94).

Impact of Oral Anticoagulants on Renal Outcomes Compared

November 21, 2017

Compared with warfarin, dabigatran and rivaroxaban linked to lower risk of adverse renal outcomes

Does Allopurinol Benefit Patients With Cardiac Syndrome X?

November 17, 2017

No improvement in exercise capacity, coronary or peripheral endothelial function after six weeks

FDA: Gout Drug Linked to Increased Risk of Heart-Related Death

By November 15, 2017

The FDA required the Uloric drug manufacturer, Takeda Pharmaceuticals, to conduct this safety study when the medicine was approved in 2009.

Evolocumab Found to Benefit Patients With PAD, History of MI

By November 15, 2017

Analysis showed that patients with more recent heart attacks experienced substantial risk reductions.

Nut Consumption 'Inversely Associated With Total Cardiovascular Disease'

November 15, 2017

Among participants who consumed 1 serving of nuts (28g) at least 5 times per week, the pooled multivariable hazard ratios for cardiovascular disease and CHD were 0.86 and 0.8, respectively.

CCBs May Improve Outcomes in Patients With Hypertrophic Cardiomyopathy

By November 14, 2017

The combined endpoint evaluated was the time to event of atrial fibrillation, ventricular arrhythmia, heart failure, myectomy, ICD implant, or sudden cardiac arrest.

Dabigatran vs. Warfarin: Incidence of Stroke, MI and Bleeding Compared

November 14, 2017

Researchers performed a retrospective cohort study to compare incidence of stroke, bleeding, and myocardial infarction in patients with atrial fibrillation initiating dabigatran or warfarin (n=25,289 for each) from November 2010 to May 2014.