The FDA analysis evaluated the safety of Xarelto in people with nonvalvular atrial fibrillation who initiated Xarelto or warfarin from November 2011 to April 2015.
Device closure for patent foramen ovale decreases recurrent stroke risk compared to medical therapy alone
Transcatheter device closure for patent foramen ovale (PFO) decreased recurrent stroke risk compared to medical therapy alone.
The researchers found that, compared with control participants, for patients with MPNs, the hazard ratios for arterial thrombosis were 3.0, 2.0, and 1.5 at 3 months, 1 year, and 5 years, respectively.
International Laboratories, LLC is notifying distributors and customers by letter and is arranging for return of all recalled products.
The Delta CHA2DS2-VASc score significantly better predicted ischemic stroke compared to baseline or follow-up CHA2DS2-VASc scores
The elevated risk of developing CVD in the ITP cohort (adjusted incidence rate ratio [IRR], 1.38) remained even after a sensitivity analysis which included only incident cases of ITP.
Compared with LVEF ≥70%, LVEF <50% and 50 to 59%, but not 60 to 69%, were independently associated with poorer outcomes in the conservative group.
Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between stroke symptoms and infarct volume results in better disability outcomes compared to standard care alone.
Systemic atherosclerosis linked with intracranial atherosclerotic disease-related stroke and worse prognosis
In patients with stroke who had intracranial atherosclerotic disease (ICAD), atherosclerotic disease in other vascular beds was more common including the aortic arch and coronary artery disease.
Reduced mortality with culprit-lesion-only percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock
In patients with acute myocardial infarction (MI) with cardiogenic shock and multivessel coronary disease, culprit-lesion-only percutaneous coronary intervention (PCI) had a lower risk of 30-day mortality compared to multivessel PCI.
The researchers found that, compared with controls, patients in the GBE group had a marked deceleration in the decline in Montreal Cognitive Assessment scores at 30 days (−2.77±0.21 versus −1.99±0.23; P=0.0116).
The researchers found that a primary-outcome event occurred in 12.8 and 13.5% of patients in the edoxaban and dalteparin groups, respectively (HR, 0.97; 95% CI, 0.70 to 1.36; P=0.006 for noninferiority; P= 0.87 for superiority).
For this group the risk of stroke was reduced by 42% (HR 0.58; 95% CI, 0.44-0.76; P<0.001), CV death by 22% (HR 0.78; 95% CI, 0.64-0.96; P=0.02) and heart attack by 14% (HR 0.86; 95% CI, 0.70-1.05; P=0.14).
The use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) was associated with a reduced risk of myocardial infarction (MI) among patients with rheumatoid arthritis (RA).
Ninety-three of the 99 patients taking AT medication continued their normal regimen through surgery and were included in the analysis.
Repatha reduced the risk of heart attack by 27%, the risk of stroke by 21% and the risk of coronary revascularization by 22%.
The greatest risk reduction of stroke or systemic embolism was seen with dabigatran 150mg twice daily (odds ratio [OR] 0.65, 95% CI: 0.52-0.81), followed by apixaban 5mg twice daily (OR 0.79, 95% CI: 0.66-0.94).
The FDA required the Uloric drug manufacturer, Takeda Pharmaceuticals, to conduct this safety study when the medicine was approved in 2009.
Among participants who consumed 1 serving of nuts (28g) at least 5 times per week, the pooled multivariable hazard ratios for cardiovascular disease and CHD were 0.86 and 0.8, respectively.
The combined endpoint evaluated was the time to event of atrial fibrillation, ventricular arrhythmia, heart failure, myectomy, ICD implant, or sudden cardiac arrest.
Researchers performed a retrospective cohort study to compare incidence of stroke, bleeding, and myocardial infarction in patients with atrial fibrillation initiating dabigatran or warfarin (n=25,289 for each) from November 2010 to May 2014.