THALITONE Rx

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THALITONE

Edema
Hypertension
Only 4 drugs may be compared at once

Generic Name and Formulations:

Chlorthalidone 15mg; tabs.

Company:

Pfizer Inc.

Select therapeutic use:

Indications for THALITONE:

Edema.

Adult:

Initially 30–60mg daily or 60mg on alternate days. Some patients may require 90–120mg at these intervals or up to 120mg daily. Maintenance: doses may be lower than initial doses; individualize.

Children:

Not established.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

May not be substituted for other forms of chlorthalidone. Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes; discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (monosulfamyl).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).

How Supplied:

Tabs—100

THALITONE 15mg tablets (Qty:45)

appx. price $81.00

Indications for THALITONE:

Hypertension.

Adult:

Initially 15mg once daily; may increase to 30mg and then to a single dose of 45–50mg. If additional control required, may add second antihypertensive. Maintenance: doses may be lower than initial doses; individualize.

Children:

Not established.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

May not be substituted for other forms of chlorthalidone. Renal or hepatic impairment. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes; discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Orthostatic hypotension with alcohol, CNS depressants. May potentiate nondepolarizing muscle relaxants, other antihypertensives (eg, ganglionic or peripheral adrenergic blocking agents). May antagonize norepinephrine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (monosulfamyl).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, CNS reactions (eg, dizziness), hematologic reactions (eg, thrombocytopenia).

How Supplied:

Tabs—100

THALITONE 15mg tablets (Qty:45)

appx. price $81.00