TAMIFLU Rx

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TAMIFLU

Viral infections
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Generic Name and Formulations:

Oseltamivir (as phosphate) 30mg, 45mg, 75mg; caps.

Select therapeutic use:

Indications for TAMIFLU:

Treatment of uncomplicated acute illness due to influenza infection in patients ≥2 weeks of age who have been symptomatic for ≤2 days. Prophylaxis of influenza in patients ≥1yr of age.

Limitations Of use:

Not a substitute for annual influenza vaccination. Consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use. Not recommended for patients with ESRD not undergoing dialysis.

Adult:

Start within 2 days of symptom onset or exposure. Unable to swallow caps; use oral susp. If oral susp. unavailable; may open caps and mix with sweetened liquids (eg, chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). If appropriate strength caps and oral susp. unavailable; have RPh compound an emergency supply of oral susp. from 75mg caps (see full labeling for preparation). ≥13yrs: Treatment: 75mg twice daily for 5 days. Prophylaxis: after close contact with infected individual: 75mg once daily for at least 10 days; during community outbreak: 75mg once daily for up to 6 weeks (or up to 12 weeks in immunocompromised). Renal impairment or ESRD on dialysis: see full labeling.

Children:

Start within 2 days of symptom onset. Unable to swallow caps; use oral susp. If oral susp. unavailable; may open caps and mix with sweetened liquids (eg, chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). If appropriate strength caps and oral susp. unavailable; have RPh compound an emergency supply of oral susp. from 75mg caps (see full labeling for preparation). Treatment: <2 weeks: not established. Treat for 5 days. ≥2 weeks to <1yr: 3mg/kg twice daily. 1–12yrs: (≤15kg): 30mg twice daily; (15.1–23kg): 45mg twice daily; (23.1–40kg): 60mg twice daily; (≥40.1kg): 75mg twice daily. Prophylaxis: <1yr: not established. Treat for 10 days; during community outbreak: continue up to 6 weeks (or up to 12 weeks in immunocompromised); 1–12yrs: (≤15kg): 30mg once daily; (15.1–23kg): 45mg once daily; (23.1–40kg): 60mg once daily; (≥40.1kg): 75mg once daily.

Warnings/Precautions:

Immunocompromised. Monitor for signs of abnormal behavior. Risk of bacterial infections. Chronic cardiac or respiratory disease. Severe hepatic impairment. Oral soln: hereditary fructose intolerance. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Do not administer live attenuated influenza vaccine within 2 weeks prior or 48 hrs after treatment.

See Also:

TAMIFLU ORAL SUSPENSION

Pharmacological Class:

Neuraminidase inhibitor.

Adverse Reactions:

Nausea, vomiting, headache, pain; also Children <1yr: diarrhea, diaper rash; serious skin/hypersensitivity reactions (discontinue if occur), possible neuropsychiatric events (eg, hallucinations, delirium, abnormal behavior).

Metabolism:

Hepatic.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Caps—10; Susp—60mL

TAMIFLU 10 capsules of 75mg dose packs (Qty:1)

appx. price $152.00