SUPREP Rx

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SUPREP

Constipation and bowel cleansers
Only 4 drugs may be compared at once

Generic Name and Formulations:

Sodium sulfate 17.5g, potassium sulfate 3.13g, magnesium sulfate 1.6g; per 6oz of soln.

Select therapeutic use:

Indications for SUPREP:

Bowel cleansing before colonoscopy.

Adult:

Start the evening before colonoscopy: dilute 1 bottle to 16oz with water and drink entire amount. Drink 32oz of water over the next hour. Next morning: repeat using the second bottle. Complete prep at least 1 hour before colonoscopy.

Children:

Not recommended.

Contraindications:

GI obstruction or perforation. Gastric retention. Toxic colitis. Toxic megacolon. Ileus.

Warnings/Precautions:

Maintain adequate hydration. Correct electrolyte abnormalities before use. Renal impairment; monitor baseline and post-colonoscopy electrolytes, creatinine, BUN. History of QT prolongation, uncontrolled arrhythmias, recent MI, unstable angina, CHF, or cardiomyopathy: increased risk of arrhythmias; consider ECGs at pre-dose and post-colonoscopy. Gout. Seizure. Inflammatory bowel disease. Severe ulcerative colitis. Impaired gag reflex. Risk of regurgitation or aspiration. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Caution with drugs that may increase risk of electrolyte abnormalities, arrhythmias or QT prolongation. Drugs administered within 1 hour of start of Suprep may not be absorbed.

Pharmacological Class:

Osmotic laxative.

Adverse Reactions:

Overall discomfort, abdominal distention and pain, nausea, vomiting; transient elevated uric acid, mucosal ulcerations and ischemic colitis.

Generic Availability:

NO

How Supplied:

Bowel prep kit—1 (2 x 6oz bottles of soln w. mixing container)