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Streptomycin Inj
Bacterial infections
Tuberculosis
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Drug Name:

Streptomycin Inj Rx

Generic Name and Formulations:
Streptomycin sulfate 1g/vial; lyophilized pwd for IM inj after reconstitution.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Streptomycin Inj:

Moderate to severe susceptible infections, including plague, tularemia, endocarditis. Second-line therapy for gram-negative bacillary bacteremia, meningitis, pneumonia, brucellosis, granuloma inguinale, chancroid, UTIs.

Adult:

Give by IM inj into gluteus maximus or mid-lateral thigh. Alternate injection sites. Tularemia: 1–2g per day in divided doses; give for 7–14 days until patient is afebrile for 5–7 days. Plague: 2g per day in 2 divided doses; give for at least 10 days. Streptococcal endocarditis: 1g twice daily for 1st week, then 500mg twice daily for for 2nd week; may be used with penicillin. >60years: 500mg twice daily for entire 2-weeks. Enterococcal endocarditis: 1g twice daily for 2 weeks, then 500mg twice daily for additional 4 weeks; given with penicillin. Other moderate to severe infections as 2nd-line therapy: 1–2g in divided doses every 6–12hrs; max 2g/day.

Children:

Give by IM inj into mid-lateral thigh. Alternate injection sites. Tularemia, plague, endocarditis: See literature. Other moderate to severe infections as 2nd-line therapy: 20–40mg/kg per day in divided doses every 6–12hrs.

Pharmacological Class:

Aminoglycoside.

Warnings/Precautions:

Renal impairment: reduce dose, monitor renal function and peak serum levels (max 20–25micrograms/mL) periodically. Perform baseline and periodic caloric stimulation, and audiometric tests with extended therapy. Discontinue if ototoxicity occurs. Venereal infections: if concomitant syphilis suspected, perform dark field examination before starting therapy then monthly serologic tests for at least 4 months. Elderly. Infants. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid concurrent or sequential use of polymyxin B, colistin, cyclosporine, other aminoglycosides, neurotoxic or nephrotoxic drugs. Ototoxicity potentiated with ethacrynic acid, furosemide, mannitol, other diuretics. May potentiate neuromuscular blockade and respiratory paralysis with anesthetics, muscle relaxants.

Adverse Reactions:

Ototoxicity (eg, cochlear and vestibular), paresthesias, rash, fever, urticaria, angioneurotic edema, eosinophilia, dermatitis, anaphylaxis, azotemia, blood dyscrasias, hemolytic anemia, muscle weakness, amblyopia; rare: nephrotoxicity.

How Supplied:

Contact supplier.

Indications for Streptomycin Inj:

Adjunct in tuberculosis.

Adult:

Give by IM inj into gluteus maximus or mid-lateral thigh. Alternate injection sites. 15mg/kg (max 1g) once daily, or 25–30mg/kg (max 1.5g) two or three times weekly. Max 120g over entire course of therapy. Treat at least 1 year. >60years: reduce dose.

Children:

Give by IM inj into mid-lateral thigh. Alternate injection sites. 20–40mg/kg (max 1g) once daily, or 25–30mg/kg (max 1.5g) two or three times weekly. Max 120g over entire course of therapy. Treat at least 1 year.

Pharmacological Class:

Aminoglycoside.

Warnings/Precautions:

Renal impairment: reduce dose, monitor renal function and peak serum levels (max 20–25micrograms/mL) periodically. Perform baseline and periodic caloric stimulation, and audiometric tests with extended therapy. Discontinue if ototoxicity occurs. Elderly. Infants. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Avoid concurrent or sequential use of polymyxin B, colistin, cyclosporine, other aminoglycosides, neurotoxic or nephrotoxic drugs. Ototoxicity potentiated with ethacrynic acid, furosemide, mannitol, other diuretics. May potentiate neuromuscular blockade and respiratory paralysis with anesthetics, muscle relaxants.

Adverse Reactions:

Ototoxicity (eg, cochlear and vestibular), paresthesias, rash, fever, urticaria, angioneurotic edema, eosinophilia, dermatitis, anaphylaxis, azotemia, blood dyscrasias, hemolytic anemia, muscle weakness, amblyopia; rare: nephrotoxicity.

How Supplied:

Contact supplier.

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