STELARA Rx

Indications for STELARA:

Moderate to severe plaque psoriasis in adults who are candidates for phototherapy or systemic therapy.

Adult Dose for STELARA:

≥18yrs: ≤100kg: 45mg SC once then 4weeks later, then once every 12weeks. >100kg: 90mg once then 4weeks later, then once every 12weeks. Rotate inj site.

Children's Dose for STELARA:

<18yrs: not recommended.

Pharmacological Class:

Interleukin-12 and interleukin-23 antagonist.

Warnings/Precautions:

Active infections: not recommended. Increased risk of serious or fatal infections, esp. in IL-12/IL-23 genetically deficient patients (eg, mycobacteria, salmonella, BCG vaccines). Monitor for new infection; discontinue if serious infection develops. Conditions that predispose to infection. Test for and treat latent tuberculosis prior to initiating therapy. Avoid close contact with live vaccine recipients. History of malignancies; monitor closely. Discontinue if reversible posterior leukoencephalopathy syndrome (RPLS) occurs or is suspected. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Concomitant live vaccines, other immunosuppressants, phototherapy: not recommended. Do not give BCG vaccines during or within 1 year of starting or stopping ustekinumab. Non-live vaccines: may get suboptimal response. May affect CYP450 substrates.

Adverse Reactions:

Nasopharyngitis, upper respiratory tract infection, headache, fatigue; infections, malignancies, RPLS, hypersensitivity reactions (discontinue if occurs).

Generic Availability:

NO

How Supplied:

Single use vial—1
Single use prefilled syringe—1