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Generic Name and Formulations:

Nateglinide 60mg, 120mg; tabs.

Select therapeutic use:

Indications for STARLIX:

Adjunct to diet and exercise in type 2 diabetes, alone (in patients who have not been chronically treated with other antidiabetic agents) or in combination with metformin or a thiazolidinedione.


Take 1–30 minutes before meals; skip dose if meal is skipped. 120mg 3 times daily. If near HbA1c goal, initially 60mg 3 times daily.


Not recommended.


Type 1 diabetes. Ketoacidosis.


Moderate to severe hepatic disease. Secondary failure may occur in prolonged therapy. Elderly, adrenal or pituitary insufficiency, stress, strenuous exercise, autonomic neuropathy, severe renal impairment, malnourished: increased risk of hypoglycemia. Labor & delivery. Pregnancy (Cat.C), nursing mothers: not recommended.


May be potentiated by salicylates, non-cardioselective β-blockers, NSAIDs, alcohol, MAOIs. May be antagonized by thiazides, corticosteroids, sympathomimetics, thyroid products. Monitor with highly protein-bound drugs. Liquid meals reduce peak levels. β-blockers mask hypoglycemia.

Pharmacological Class:

Insulin secretagogue (amino acid deriv.).

Adverse Reactions:

Hypoglycemia, GI upset with metformin, peripheral edema with rosiglitazone.

How Supplied:

Tabs—100, 500

STARLIX 60mg tablets (Qty:90)

appx. price $329.00