Reporting on a study of the reaction of children to morphine administration at SLEEP 2015, Gaspard Montandon, PhD, University of Toronto, said that respiratory depression was "more severe when patients were in states of reduced arousal due to the sedative properties of morphine."
Severe obstructive sleep apnea syndrome (OSAS) may potentially be associated with pancreatic β-cell functional disorder and glucagon-like peptide-1 (GLP-1) resistance, according to a study presented at SLEEP 2015.
Chewing caffeine gum for five minutes immediately upon awakening may counter sleep inertia, especially for reaction time, according to a data presented at SLEEP 2015.
Treating obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) has shown incremental improvement in physical activity (PA) and sleep quality in as early three months, according to data presented at SLEEP 2015.
Administration of a non-benzodiazepine sedative hypnotic (NBSH) does not increase the likelihood of having a low arousal phenotype for obstructive sleep apnea (OSA), a study presented at SLEEP 2015 has concluded.
The orexin receptor antagonist suvorexant improves sleep in patients with insomnia, analysis of pooled results of two Phase 3 clinical trials presented at SLEEP 2015 have found.
Lemborexant (E2006), a dual orexin receptor antagonist (DORA) under development for insomnia disorder, led to a decrease in latency to persistent sleep (LPS) and wake after sleep onset (WASO) and an increase in sleep efficiency (SE), according to data presented at SLEEP 2015.
Sodium oxybate improved health-related quality-of-life (HRQoL) measures in patients with narcolepsy in a dose-dependent manner, results from a randomized placebo-controlled trial presented at SLEEP 2015 have found.
Pharmacotherapy improves multiple domains of functioning in patients with central disorders of hypersomnolence (CDH) in a "real-world" tertiary care setting, according to data presented at SLEEP 2015.
According to data presented at SLEEP 2015, children with obstructive sleep apnea syndrome (OSAS) that adhered to positive airway pressure (PAP) therapy demonstrated improvements in quality of life (QoL).
A case study presented at SLEEP 2015 suggest that an influenza vaccination may have triggered status cataplecticus in the female patient with known narcolepsy.
The effect of cognitive behavioral therapy for insomnia (CBT-I) does not vary based on medication use or comorbidity, according to data presented at SLEEP 2015.
Milnacipran does not directly improve sleep continuity and architecture but its impact on sleep improvement can be attributed to its effectiveness in reducing pain, according to data presented at SLEEP 2015.
When eszopiclone was given instead of zolpidem, no difference was observed on the polysomnogram diagnostic and positive airway pressure (PAP)-titration portions, according to data reported at SLEEP 2015.
Serum glucose is not a reliable biomarker for predicting obstructive sleep apnea (OSA) or whether treatment is effective with continuous positive airway pressure (CPAP), a pilot study of biomarkers presented at SLEEP 2015 concluded.
An 80-year-old male with new onset myasthenia gravis and narcolepsy with cataplexy had symptomatic improvement with sodium oxybate—but not with immune-modulating agents, results of a case study presented at SLEEP 2015 have shown.
Cognitive behavioral therapy for insomnia (CBT-I) did not appear to abrogate the frequency or burden of antidepressant side effects in patients with comorbid major depressive disorder (MDD), results from the multi-site Treatment of Insomnia and Depression (TRIAD) study presented at SLEEP 2015 have shown.
Positive airway pressure (PAP) improved blood pressure and sleep-related symptoms in an unselected clinical population of patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA), but did not improve glycemic control, according to data presented at SLEEP 2015.
In children with obstructive sleep apnea (OSA), pressure delivered by auto-adjusting CPAP (APAP) is significantly lower than that determined to be the optimal pressure derived from CPAP titration polysomnogram (PSG), results of a study presented at SLEEP 2015 have found.
E2006, a novel dual orexin receptor antagonist (DORA), has shown efficacy for both subject-reported sleep onset and maintenance on sleep diary measures, according to Phase 2 study results reported at SLEEP 2015.
Almorexant, a hypocretin receptor antagonist, produced fewer acute cognitive effects than the GABAA receptor modulator zolpidem, according to results of a randomized controlled trial presented at SLEEP 2015.
Treatment with gabapentin enacarbil at both the 600mg and 1200mg doses "led to a greater number of adult patients who met the criteria for a combined pain and International Restless Legs Scale (IRLS) total score response" compared to placebo, a study presented at SLEEP 2015 confirmed.
At SLEEP 2015, research demonstrating that cognitive behavioral therapy (CBT) may indirectly improve fibromyalgia symptoms via improved sleep was presented.
For about one-third of patients treated with zolpidem, only partial improvement is observed, researchers reported at SLEEP 2015.
Patients with insomnia had "small but significant improvements" in symptoms of sleep efficiency and depth of sleep after consuming a milk product with naturally enhanced levels of melatonin and other bioactive components, results of a randomized trial reported at SLEEP 2015 have shown.
In patients with heart failure and reduced ejection fraction, supervised exercise training has "important therapeutic benefits" when added to continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA), according to results of a prospective randomized trial reported at SLEEP 2015.
Internet-based cognitive behavioral therapy for insomnia (CBT-I) resulted in significant and lasting improvements in people's sleep and daily functioning, according to data from a randomized controlled trial presented at SLEEP 2015.
An increase in body mass index (BMI) was observed following initiation of continuous positive airway pressure (CPAP) therapy, so implementation of nutritional and exercise interventions is recommended, according to data reported at SLEEP 2015