Sleep 2015

In Children, Reduced Arousal Aggravates Respiratory Depression By Morphine

June 11, 2015

Reporting on a study of the reaction of children to morphine administration at SLEEP 2015, Gaspard Montandon, PhD, University of Toronto, said that respiratory depression was "more severe when patients were in states of reduced arousal due to the sedative properties of morphine."

How Does OSAS Severity Affect Glucose Tolerance?

June 11, 2015

Severe obstructive sleep apnea syndrome (OSAS) may potentially be associated with pancreatic β-cell functional disorder and glucagon-like peptide-1 (GLP-1) resistance, according to a study presented at SLEEP 2015.

Chew on This: Caffeine Gum Put to the Test in New Study

By June 11, 2015

Chewing caffeine gum for five minutes immediately upon awakening may counter sleep inertia, especially for reaction time, according to a data presented at SLEEP 2015.

Physical Activity, Sleep Quality Boosted With CPAP in OSA

June 11, 2015

Treating obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) has shown incremental improvement in physical activity (PA) and sleep quality in as early three months, according to data presented at SLEEP 2015.

Some Sedative Hypnotics Not Ideal for Predicting Low-Arousal Threshold

By June 11, 2015

Administration of a non-benzodiazepine sedative hypnotic (NBSH) does not increase the likelihood of having a low arousal phenotype for obstructive sleep apnea (OSA), a study presented at SLEEP 2015 has concluded.

Which Foods May Lead to Poor Sleep, Bad Dreams?

June 11, 2015

Foods and dietary habits may significantly impact sleeping and dreaming, investigators reported at SLEEP 2015.

Study: Suvorexant Improves Sleep, Daytime Functioning at Two Doses

June 11, 2015

The orexin receptor antagonist suvorexant improves sleep in patients with insomnia, analysis of pooled results of two Phase 3 clinical trials presented at SLEEP 2015 have found.

Lemborexant Shows Equivalent Efficacy in Men, Women With Insomnia

By June 11, 2015

Lemborexant (E2006), a dual orexin receptor antagonist (DORA) under development for insomnia disorder, led to a decrease in latency to persistent sleep (LPS) and wake after sleep onset (WASO) and an increase in sleep efficiency (SE), according to data presented at SLEEP 2015.

Sodium Oxybate Found to Improve Health-Related Quality of Life Measures

By June 11, 2015

Sodium oxybate improved health-related quality-of-life (HRQoL) measures in patients with narcolepsy in a dose-dependent manner, results from a randomized placebo-controlled trial presented at SLEEP 2015 have found.

Pharmacotherapy Improves Function in Patients With Narcolepsy in 'Real-World' Setting

By June 11, 2015

Pharmacotherapy improves multiple domains of functioning in patients with central disorders of hypersomnolence (CDH) in a "real-world" tertiary care setting, according to data presented at SLEEP 2015.

Longer PAP Therapy May Mean Better QoL in Children With OSAS

By June 11, 2015

According to data presented at SLEEP 2015, children with obstructive sleep apnea syndrome (OSAS) that adhered to positive airway pressure (PAP) therapy demonstrated improvements in quality of life (QoL).

Flu Vaccine Triggers Status Cataplecticus in Teen With Narcolepsy

By June 11, 2015

A case study presented at SLEEP 2015 suggest that an influenza vaccination may have triggered status cataplecticus in the female patient with known narcolepsy.

Concomitant Hypnotics, Comorbidities Not Factors in CBT-I Efficacy

By June 11, 2015

The effect of cognitive behavioral therapy for insomnia (CBT-I) does not vary based on medication use or comorbidity, according to data presented at SLEEP 2015.

SSRI Could Improve Sleep via Fibromyalgia Relief

By June 11, 2015

Milnacipran does not directly improve sleep continuity and architecture but its impact on sleep improvement can be attributed to its effectiveness in reducing pain, according to data presented at SLEEP 2015.

Longer Sleep May Have Protective Effect on Pain

By June 11, 2015

Endogenous pain regulatory function is impacted by sleep duration, according to data presented at SLEEP 2015,

Comparable Effects Seen With Zolpidem, Eszopiclone in PAP Titration

June 10, 2015

When eszopiclone was given instead of zolpidem, no difference was observed on the polysomnogram diagnostic and positive airway pressure (PAP)-titration portions, according to data reported at SLEEP 2015.

Biomarkers May Help Predict OSA, Effective CPAP Tx

By June 10, 2015

Serum glucose is not a reliable biomarker for predicting obstructive sleep apnea (OSA) or whether treatment is effective with continuous positive airway pressure (CPAP), a pilot study of biomarkers presented at SLEEP 2015 concluded.

Case Study: New Onset Myasthenia Gravis and Narcolepsy With Cataplexy

By June 10, 2015

An 80-year-old male with new onset myasthenia gravis and narcolepsy with cataplexy had symptomatic improvement with sodium oxybate—but not with immune-modulating agents, results of a case study presented at SLEEP 2015 have shown.

CBT-I Ups Antidepressant Side Effects in Patients With Insomnia, MDD

June 10, 2015

Cognitive behavioral therapy for insomnia (CBT-I) did not appear to abrogate the frequency or burden of antidepressant side effects in patients with comorbid major depressive disorder (MDD), results from the multi-site Treatment of Insomnia and Depression (TRIAD) study presented at SLEEP 2015 have shown.

Better Glycemic Control Predicts Greater PAP Benefits in OSA

By June 10, 2015

Positive airway pressure (PAP) improved blood pressure and sleep-related symptoms in an unselected clinical population of patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA), but did not improve glycemic control, according to data presented at SLEEP 2015.

APAP vs. Fixed-Pressure CPAP in Peds With OSA

By June 10, 2015

In children with obstructive sleep apnea (OSA), pressure delivered by auto-adjusting CPAP (APAP) is significantly lower than that determined to be the optimal pressure derived from CPAP titration polysomnogram (PSG), results of a study presented at SLEEP 2015 have found.

Novel DORA Agent Promising As Insomnia Treatment

By June 10, 2015

E2006, a novel dual orexin receptor antagonist (DORA), has shown efficacy for both subject-reported sleep onset and maintenance on sleep diary measures, according to Phase 2 study results reported at SLEEP 2015.

Fewer Cognitive Effects Seen With Almorexant Than BZD Receptor Agonists

By June 10, 2015

Almorexant, a hypocretin receptor antagonist, produced fewer acute cognitive effects than the GABAA receptor modulator zolpidem, according to results of a randomized controlled trial presented at SLEEP 2015.

Two Gabapentin Enacarbil Doses Found to Reduce Pain, RLS Symptoms

By June 10, 2015

Treatment with gabapentin enacarbil at both the 600mg and 1200mg doses "led to a greater number of adult patients who met the criteria for a combined pain and International Restless Legs Scale (IRLS) total score response" compared to placebo, a study presented at SLEEP 2015 confirmed.

The Link Between Fibromyalgia and Sleep: How CBT Can Help

June 10, 2015

At SLEEP 2015, research demonstrating that cognitive behavioral therapy (CBT) may indirectly improve fibromyalgia symptoms via improved sleep was presented.

Factors Identified in Zolpidem Treatment Failure for Insomnia

By June 10, 2015

For about one-third of patients treated with zolpidem, only partial improvement is observed, researchers reported at SLEEP 2015.

Enhanced Milk May Lead to Small But Significant Improvements in Insomnia

June 10, 2015

Patients with insomnia had "small but significant improvements" in symptoms of sleep efficiency and depth of sleep after consuming a milk product with naturally enhanced levels of melatonin and other bioactive components, results of a randomized trial reported at SLEEP 2015 have shown.

How CPAP Patients With Heart Failure, OSA Could Benefit From Exercise Too

By June 10, 2015

In patients with heart failure and reduced ejection fraction, supervised exercise training has "important therapeutic benefits" when added to continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA), according to results of a prospective randomized trial reported at SLEEP 2015.

Internet-Based Program Can Help More Insomnia Patients Get Treatment

June 10, 2015

Internet-based cognitive behavioral therapy for insomnia (CBT-I) resulted in significant and lasting improvements in people's sleep and daily functioning, according to data from a randomized controlled trial presented at SLEEP 2015.

Unexpected BMI Changes Seen After CPAP Therapy

By June 10, 2015

An increase in body mass index (BMI) was observed following initiation of continuous positive airway pressure (CPAP) therapy, so implementation of nutritional and exercise interventions is recommended, according to data reported at SLEEP 2015