SINEMET Rx

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SINEMET

Parkinsonism
Only 4 drugs may be compared at once

Generic Name and Formulations:

Carbidopa, levodopa; 10-100, 25-100, 25-250; tabs.

Select therapeutic use:

Indications for SINEMET:

Parkinsonism.

Adult:

≥18yrs: Initially one Sinemet 25-100 tab 3 times daily or one Sinemet 10-100 tab 3–4 times daily; increase every 1–2 days up to 2 tabs (of either 25-100 or 10-100 tabs) 4 times daily. If more levodopa is needed, initially one Sinemet 25-250 tab 3–4 times daily; max 8 tabs daily.

Children:

<18yrs: not recommended.

Contraindications:

During or within 14 days of nonselective MAOIs (eg, phenelzine). Narrow-angle glaucoma. Undiagnosed skin lesions. History of melanoma.

Warnings/Precautions:

Severe cardiovascular or pulmonary disease. Asthma. Renal, hepatic, or endocrine disorders. History of peptic ulcer or MI with residual arrhythmias. Suicidal tendencies. Psychosis. Orthostatic hypotension. Chronic wide-angle glaucoma. Discontinue levodopa at least 12 hrs before starting Sinemet or Sinemet CR. Sinemet CR not bioequivalent to Sinemet; see literature when switching forms. Monitor renal and liver function, intraocular pressure, blood counts. May stain body fluids. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Orthostatic hypotension with selegiline, antihypertensives. Antagonized by phenothiazines, butyrophenones, risperidone, phenytoin, papaverine. Hypertension, dyskinesia with tricyclic antidepressants. May be antagonized by iron, high protein diets. May cause false (+) urinary ketone test or false (–) urinary glucose (glucose oxidase) test.

See Also:

SINEMET CR

Pharmacological Class:

Dopa-decarboxylase inhibitor + dopamine precursor.

Adverse Reactions:

Dyskinesia, GI upset, hallucinations, confusion, psychological disturbances, depression, dizziness, headache, dream abnormalities, dystonia, cardiac arrhythmias, hypotension, dyspnea, on-off phenomenon, back pain, blepharospasm (may indicate excess dosage), hypertension, anticholinergic effects, anorexia, insomnia, leukopenia, renal and liver function disorders, seizures, neuroleptic malignant syndrome.

How Supplied:

CR—100, 500; Tabs—100

SINEMET 25mg/100mg tablets (Qty:90)

appx. price $121.00