SELZENTRY
Generic Name for SELZENTRY
Maraviroc 150mg, 300mg; tabs.
Legal Classification:
Rx
Pharmacological Class for SELZENTRY
CCR5 co-receptor antagonist.
Manufacturer of SELZENTRY
Pfizer Labs
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Indications for SELZENTRY
HIV-1 infection in treatment-experienced adults infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretrovirals.
Adult dose for SELZENTRY
Swallow whole. ≥16yrs: Concomitant CYP3A inhibitors (eg, PIs except tipranavir/ritonavir, delavirdine, ketoconazole, itraconazole, clarithromycin, nefazodone, telithromycin) (with or without a CYP3A inducer): 150mg twice daily. Other concomitant drugs, including tipranavir/ritonavir, nevirapine, NRTIs, enfuvirtide: 300mg twice daily. Concomitant CYP3A inducers (eg, efavirenz, rifampin, carbamazepine, phenobarbital, phenytoin) (without a strong CYP3A inhibitor): 600mg twice daily. Renal dysfunction (CrCl<50mL/min) and CYP3A inhibitors: monitor closely for side effects (eg, dizziness).
Children's dosing for SELZENTRY
<16yrs: not recommended.
Warnings/Precautions for SELZENTRY
Do tropism testing before starting therapy. Pre-existing liver dysfunction or co-infected with viral hepatitis B or C. Consider discontinuing therapy if hepatitis or elevated LFTs with rash or other systemic symptoms develop. Cardiovascular risk factors. Postural hypotension. Monitor for immune reconstitution syndrome, infections, malignancies. Pregnancy (Cat. B). Nursing mothers: not recommended.
Interactions for SELZENTRY
Concomitant St. John's wort: not recommended. May affect, or be affected by, CYP3A inhibitors or inducers and drugs affected by p-glycoprotein (eg, potentiated by ketoconazole, lopinavir/ritonavir, ritonavir, saquinavir, atazanavir; antagonized by rifampin, efavirenz). Caution with antihypertensives.
Adverse Reactions for SELZENTRY
Upper respiratory tract infections, cough, pyrexia, upper respiratory infections, rash, musculoskeletal symptoms, constipation, dizziness; hepatotoxicity (may be preceded by systemic allergic reaction; immediately evaluate if occurs); others (see literature).
How is SELZENTRY supplied?
Tabs—60
Related Disease:
HIV~antivirals