Take 8mg within 30min of bedtime. Do not take with high-fat/heavy meals (delays effect).
Hypnotic (melatonin agonist).
Severe hepatic impairment. Concomitant fluvoxamine.
Severe COPD, severe obstructive sleep apnea: not recommended. Moderate hepatic impairment. Depression. Behavioral changes. Monitor prolactin and testosterone levels if unexplained amenorrhea, galactorrhea, decreased libido, or fertility problems occur. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
See Contraindications. Avoid alcohol. Potentiated by potent inhibitors of CYP1A2, CYP3A4 (eg, ketoconazole), CYP2C9 (eg, fluconazole). Antagonized by potent CYP450 inducers (eg, rifampin).
Somnolence, complex sleep-related behaviors (eg, sleep-driving), dizziness, fatigue; reduced testosterone or cortisol levels, increased prolactin levels (monitor if occurs); anaphylaxis, angioedema, others (see literature).
Tabs—30, 100, 500