Attention deficit hyperactivity disorder. Narcolepsy.
10–60mg daily in 2–3 divided doses preferably 30–45mins before meals.
<6yrs: not recommended. ≥6yrs: initially 5mg twice daily before breakfast and lunch. May increase by 5–10mg weekly; max 60mg/day.
Marked anxiety, tension, agitation. Glaucoma. History of tics or Tourette's syndrome in patient or family. During or within 14 days of MAOIs.
History of drug dependence or alcoholism; monitor for abnormal behavior. Structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease: not recommended. Hypertension. Heart failure. Recent MI. Arrhythmias. Assess cardiovascular status. Reduce dose or discontinue if paradoxical worsening of symptoms occurs. Reevaluate periodically. Psychosis. Bipolar disorder. Monitor for worsening aggressive behavior or hostility. Seizure disorders; discontinue if occur. Peripheral vasculopathy including Raynaud's Phenomenon; monitor for digital changes. Monitor growth, BP, CBC, differential, platelet counts, vision. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Avoid alcohol. Caution with pressor agents. May increase levels of anticonvulsants, oral anticoagulants, tricyclics, antipsychotics (eg, haloperidol). Antagonizes other antihypertensives. Drugs that affect GI pH may affect release of methylphenidate from caps.
Insomnia, nervousness, CNS overstimulation, anorexia, weight loss, abdominal pain, nausea, dizziness, headache, dyskinesias, hypertension, tachycardia, blood dyscrasias, rash; Tourette's syndrome, toxic psychosis, seizures, visual disturbances, priapism.