RISPERDAL CONSTA
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RISPERDAL CONSTA to:
Generic Name for RISPERDAL CONSTA
Risperidone 12.5mg, 25mg, 37.5mg, 50mg; per vial; pwd for long-acting IM inj after reconstitution.
Legal Classification:
Rx
Pharmacological Class for RISPERDAL CONSTA
Benzisoxazole.
Manufacturer of RISPERDAL CONSTA
Janssen Pharmaceutica Products, LP
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Indications for RISPERDAL CONSTA
Schizophrenia.
Adult dose for RISPERDAL CONSTA
Risperidone-naive: rule out risperidone hypersensitivity before using injection. Give by deep deltoid or gluteal IM inj; alternate sides. Give with oral risperidone (or other antipsychotic) for 3 weeks, then stop oral form. ≥18yrs: 25mg IM every 2 weeks; may adjust dose every 4 weeks. Max 50mg every 2 weeks. Renal or hepatic impairment: if total daily dose of at least 2mg of oral risperidone tolerated, may give 12.5mg or 25mg IM every 2 weeks. History of poor tolerability to psychotropic drugs or drug interactions that increase risperidone plasma levels (see literature): may use lower initial dose of 12.5mg.
Children's dosing for RISPERDAL CONSTA
<18yrs: not recommended.
Also:
Warnings/Precautions for RISPERDAL CONSTA
Diabetes risk factors (obtain baseline fasting blood sugar). Monitor for hyperglycemia. Cardio- or cerebrovascular disease. Renal or hepatic dysfunction. Orthostatic hypotension. Pre-existing low WBC count or history of leukopenia/neutropenia: monitor CBC during 1st few months of therapy; discontinue if WBCs decline. Parkinson's disease. Dementia with Lewy bodies. Diseases that affect metabolic or hemodynamic response. History of breast cancer or seizures. Dysphagia. Reevaluate periodically. Monitor for neuroleptic malignant syndrome. May have antiemetic effect. Exposure to extreme temperatures. Suicidal patients. Elderly (not for dementia-related psychosis); consider monitoring renal function and for orthostatic effects. Pregnancy (Cat.C). Nursing mothers: not recommended (do not breastfeed until at least 12 weeks after last injection).
Interactions for RISPERDAL CONSTA
Avoid alcohol. Caution with other CNS drugs. May potentiate antihypertensives. May antagonize levodopa, dopamine agonists. Clearance may be decreased by clozapine; may be increased by carbamazepine, other enzyme inducers (eg, phenytoin, rifampin, phenobarbital); adjust risperidone dose. May be potentiated by cimetidine, ranitidine. May be affected by fluoxetine, paroxetine, others that affect CYP isoenzymes. Monitor valproate.
Adverse Reactions for RISPERDAL CONSTA
Headache, somnolence, increased appetite, fatigue, rhinitis, upper respiratory tract infection, vomiting, coughing, urinary incontinence, increased saliva, constipation, fever, parkinsonism, dystonia, abdominal pain, anxiety, GI upset, dizziness, dry mouth, tremor, rash, akathisia; orthostatic hypotension, tardive dyskinesia, neuroleptic malignant syndrome, hyperprolactinemia, priapism, leukopenia/neutropenia, agranulocytosis, thrombotic thrombocytopenic purpura (rare).
How is RISPERDAL CONSTA supplied?
Inj: single-use vial—1 (pack w. diluent, supplies)
Tabs 0.25mg, 0.5mg, 1mg, 2mg, 3mg—60, 500
4mg—60
Oral soln—30mL (w. pipette)
M-Tabs—28
Related Disease:
Schizophrenia