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REVATIO INJECTION

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Generic Name for REVATIO INJECTION

Sildenafil 10mg/vial; soln for IV inj.

Legal Classification:

Pharmacological Class for REVATIO INJECTION

Phosphodiesterase type 5 inhibitor (cGMP-specific).

Manufacturer of REVATIO INJECTION

Pfizer Inc.

Indications for REVATIO INJECTION

Pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise ability and delay clinical worsening, in patients who are temporarily unable to take oral Revatio.

Adult dose for REVATIO INJECTION

Give by IV bolus inj. 10mg 3 times daily.

Children's dosing for REVATIO INJECTION

Not recommended.

Also:

REVATIO

Contraindications for REVATIO INJECTION

Concomitant organic nitrates.

Warnings/Precautions for REVATIO INJECTION

Pulmonary veno-occlusive disease: not recommended. PAH secondary to sickle cell anemia. Cardiovascular disease (eg, MI, stroke, or life-threatening arrhythmias within 6 months; BP<90/50 or >170/110; coronary artery disease, unstable angina, LV outflow obstruction, fluid depletion, impaired autonomic regulation of BP). Retinitis pigmentosa. Anatomical penile deformation. Predisposition to priapism. Severe renal or hepatic impairment. Active peptic ulcer. Bleeding disorders. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions for REVATIO INJECTION

See Contraindications. Hypotension with nitrates. Concomitant potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir): not recommended. Potentiated by inhibitors of CY3A4 or CYP2C9, or cimetidine; may need dose adjustment. Antagonized by CYP3A4 inducers (eg, rifampin), bosentan; may need to adjust dose. Concomitant α-blockers (eg, doxazosin) may cause symptomatic hypotension. Potentiates bleeding risk with Vit. K antagonists. Concomitant Viagra or other PDE5 inhibitors: not recommended.

Adverse Reactions for REVATIO INJECTION

Epistaxis, headache, GI upset, flushing, insomnia, erythema, dyspnea worsened, rhinitis, sinusitis, myalgia, pyrexia, paresthesia; hypotension, vision or hearing loss, priapism.

How is REVATIO INJECTION supplied?

Tabs—90
Single-use vial—1

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