Select therapeutic use:
Indications for RETROVIR TABLETS:
HIV infection. Prevention of maternal-fetal HIV transmission.
≥18yrs: 600mg daily in divided doses. End-stage renal disease on dialysis: 100mg every 6–8 hours. Vertical transmission, severe anemia and/or neutropenia: see literature.
<6 weeks and/or for vertical transmission: see literature. 6 weeks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m2/day (240mg/m2 twice daily or 160mg/m2 3 times daily).
Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues, other forms of zidovudine. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone increase zidovudine levels. Monitor phenytoin. May be antagonized by rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.
Nucleoside analogue (reverse transcriptase inhibitor).
Anemia, neutropenia, headache, malaise, GI disturbances, insomnia, pain, myopathy, neuropathy, myositis, thrombocytopenia, lactic acidosis, steatosis, hepatomegaly, fat redistribution, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.
Register pregnant patients exposed to zidovudine by calling (800) 258-4263.
Tabs—60; Caps—100; Syrup—240mL; IV (20mL/vial)—10