Select therapeutic use:
Indications for RETROVIR SYRUP:
HIV infection, in combination with other antiretrovirals. Prevention of maternal-fetal HIV transmission.
≥18yrs: 600mg daily in divided doses. Renal impairment (CrCl <15mL/min) or on dialysis: 100mg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.
<6 weeks and/or for vertical transmission: see full labeling. 4 weeks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m2/day (240mg/m2 twice daily or 160mg/m2 3 times daily).
Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly and steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Risk of myopathy with prolonged use. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Monitor for lipoatrophy; if suspected, switch to alternative therapy. Latex allergy (IV). Elderly. Pregnancy. Nursing mothers: not recommended.
Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Potentiated by fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone. Monitor phenytoin. May be antagonized by clarithromycin, rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.
Nucleoside analogue (reverse transcriptase inhibitor).
Headache, malaise, nausea, vomiting, anorexia, insomnia, pain, neuropathy, myositis, thrombocytopenia, anemia, neutropenia, myopathy, lactic acidosis, steatosis, hepatomegaly, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.
Register pregnant patients exposed to zidovudine by calling (800) 258-4263.
Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—10