RETROVIR IV
Generic Name for RETROVIR IV
Zidovudine 10mg/mL; for IV infusion after dilution; preservative-free.
Legal Classification:
Rx
Pharmacological Class for RETROVIR IV
Nucleoside analogue (reverse transcriptase inhibitor).
Manufacturer of RETROVIR IV
GlaxoSmithKline Pharmaceuticals
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Indications for RETROVIR IV
HIV infection. Prevention of maternal-fetal HIV transmission.
Adult dose for RETROVIR IV
Give by IV infusion over 1 hour; use only until oral therapy can be given. 1mg/kg 5–6 times daily. End-stage renal disease on dialysis: 1mg/kg every 6–8 hours. Vertical transmission, severe anemia and/or neutropenia: see literature.
Children's dosing for RETROVIR IV
Vertical transmission: see literature.
Also:
Warnings/Precautions for RETROVIR IV
Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for RETROVIR IV
Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues, other forms of zidovudine. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone increase zidovudine levels. Monitor phenytoin. May be antagonized by rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.
Adverse Reactions for RETROVIR IV
Anemia, neutropenia, headache, malaise, GI disturbances, insomnia, pain, myopathy, neuropathy, myositis, thrombocytopenia, lactic acidosis, steatosis, hepatomegaly, fat redistribution, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.
Notes for RETROVIR IV
Register pregnant patients exposed to zidovudine by calling (800) 258-4263.
How is RETROVIR IV supplied?
Tabs—60
Caps—100
Syrup—240mL
IV (20mL/vial)—10
Related Disease:
HIV~antivirals