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RETROVIR CAPSULES

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Generic Name for RETROVIR CAPSULES

Zidovudine 100mg.

Legal Classification:

Pharmacological Class for RETROVIR CAPSULES

Nucleoside analogue (reverse transcriptase inhibitor).

Manufacturer of RETROVIR CAPSULES

GlaxoSmithKline Pharmaceuticals

Indications for RETROVIR CAPSULES

HIV infection. Prevention of maternal-fetal HIV transmission.

Adult dose for RETROVIR CAPSULES

≥18yrs: 600mg daily in divided doses. End-stage renal disease on dialysis: 100mg every 6–8 hours. Vertical transmission, severe anemia and/or neutropenia: see literature.

Children's dosing for RETROVIR CAPSULES

<6 weeks and/or for vertical transmission: see literature. 6 weeks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m²/day (240mg/m² twice daily or 160mg/m² 3 times daily).

Also:

RETROVIR IV

RETROVIR SYRUP

RETROVIR TABLETS

Warnings/Precautions for RETROVIR CAPSULES

Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions for RETROVIR CAPSULES

Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues, other forms of zidovudine. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone increase zidovudine levels. Monitor phenytoin. May be antagonized by rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.

Adverse Reactions for RETROVIR CAPSULES

Anemia, neutropenia, headache, malaise, GI disturbances, insomnia, pain, myopathy, neuropathy, myositis, thrombocytopenia, lactic acidosis, steatosis, hepatomegaly, fat redistribution, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.

Notes for RETROVIR CAPSULES

How is RETROVIR CAPSULES supplied?

Tabs—60; Caps—100; Syrup—240mL; IV (20mL/vial)—10

Related Disease:

HIV~antivirals

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