Respiratory Disorders

Data Support FDA Restrictions on Child Cough and Cold Medicines

July 16, 2018

Surveillance data showed more adverse events for children exposed to hydrocodone than codeine

Asthma Control and Atrial Fibrillation Risk: Is There a Link?

July 13, 2018

Dose-response association seen between levels of asthma control and risk of atrial fibrillation

Harmful Internet "Challenges" and Teens: A Guide for Primary Care Providers

July 12, 2018

Discussions involving Internet challenges with children and adolescents should be as sensitive as those about sexuality and drug or alcohol use.

Aspirin Desensitization May Improve Alcohol-Induced Symptoms in AERD Patients

By July 11, 2018

In addition to respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), patients with AERD oftentimes experience an additional allergic reaction when drinking alcohol.

Is Short-Course Antibiotic Treatment for CAP Effective?

By July 11, 2018

To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).

Physician Sued by Noncompliant Patient After Failing to Follow Up on Test

By July 10, 2018

Timely review and appropriate follow up on all patient reports is essential and must be part of a practice's routine.

Budesonide With Saline Solution Helpful for Rhinosinusitis

July 09, 2018

The researchers found that the budesonide group had a mean score on the Sino-Nasal Outcome Test (SNOT-22) that was 7 points better (95% confidence interval, −2 to 16) than the control group.

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

By July 06, 2018

Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.

Asthma Treatments: Inhalations

July 06, 2018

Inhalation doses for the treatment of asthma and prevention of exercise induced bronchospasm (EIB).

Smoking Marijuana May Be Tied to Cough, Sputum Production

July 03, 2018

Insufficient evidence for link between marijuana and pulmonary function, obstructive lung disease

Use of Palliative Care, Oxygen Therapy Increasing for COPD

July 03, 2018

Increase in use of formal palliative care services, long-term oxygen, but proportions still remain low

Patient Engagement in Asthma Treatment Plans May Improve Quality of Life

July 02, 2018

In older adults with asthma, decision making scores positively correlated with QoL scores

Zephyr Valve Approved for Treating Patients With Severe Emphysema

By July 02, 2018

The approval was based on results from a multicenter study (LIBERATE) of 190 patients with severe emphysema.

Combination of LABA + Inhaled Glucocorticoid Safe in Asthma

June 28, 2018

The researchers identified 3 asthma-related intubations (2 in the inhaled-glucocorticoid group, 1 in the combination therapy group) and 2 asthma-related deaths (both in the combination-therapy group) in 4 patients among the 36,010 patients in the intention-to-treat study.

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

By June 20, 2018

Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.

Increased Risk of MI, Ischemic Stroke After COPD Exacerbation

June 19, 2018

Greater risks were seen following a severe exacerbation (incidence rate ratios, 2.58 and 1.97 for myocardial infarction and ischemic stroke, respectivley) than after a moderate exacerbation (incidence rate ratios, 1.58 and 1.45, respectively).

Adenoid, Tonsil Removal May Affect Later Respiratory Risks

June 08, 2018

Participants were evaluated in linked national registers up to 2009, and incidence of disease was examined up to age 30 years, with adjustment for 18 covariates.

Recombinant human pentraxin 2 slows the decline in lung function in idiopathic pulmonary fibrosis

June 07, 2018

The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis.

Respiratory Pathogens May Up Treatment Failure Risk in Asthma

June 07, 2018

There was a correlation for non-rhinovirus pathogens with increased absolute risk of treatment failure by 13.1%; specifically, by 8.8, 24.9, and 34.1% for respiratory syncytial virus, influenza, and parainfluenza, respectively.

Viruses not linked to asthma exacerbation severity

June 04, 2018

Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure. Evidence Rating Level: 2 (Good).

Recall: Rhinitis Treatment May Contain Small Glass Particles

By May 31, 2018

Fluticasone Propionate Nasal Spray is a corticosteroid indicated for the management of the nasal symptoms of perennial nonallergic rhinitis in adults and pediatric patients aged 4 years and older.

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

May 23, 2018

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Slower Decline in Lung Function With Anthocyanin Intake

May 22, 2018

Slower annual rates of decline were seen in FEV1 and FVC for participants with the highest quartile of anthocyanin intake (−9.8mL/year for both). The FEV1/FVC ratio decline was also slower for the highest versus the lowest quartile of anthocyanin intake (−0.02/year).

Impact of Allergic Rhinitis, Rhinoconjunctivitis on Adolescents "Far-Reaching"

By May 21, 2018

A total of 27 articles were identified. Of these, 6 evaluated symptoms, 9 assessed QOL, 5 studied daily activities, 3 evaluated emotional aspects, 6 assessed sleep, 7 studied education, and 2 evaluated treatment burden.

Homeopathic Products for Teething, Nausea, Colic, Cough Recalled

By May 18, 2018

Recalled products include Teething Drops, Nausea Drops, Intestinal Colic Drops, Stomach Calm, Expectorant Cough Syrup, Silver-Zinc Throat Spray, and Argentum Elixir.

Two Novel Immune-Response Clusters Identified to RSV

May 18, 2018

"Distinct immune-response clusters during infant RSV infection and their association with risk of recurrent wheeze provide insights into the risk factors for and mechanisms of asthma development," the authors write.

Chemicals in Hair Products for Black Women Raise Concerns

May 18, 2018

Cyclosiloxanes, parabens, and the fragrance marker diethyl phthalate (DEP) were found at the highest levels, with DEP found most frequently.

Immune Checkpoint Inhibitor Efficacy Varies by Sex

May 17, 2018

The researchers found that, compared with men treated in control groups, the pooled overall survival hazard ratio was 0.72 for male patients treated with immune checkpoint inhibitors.

Budesonide-Formoterol Used As Needed Beneficial in Mild Asthma

May 17, 2018

"These two trials show persuasively that treatment with budesonide-formoterol on an as-needed basis prevented the most serious outcomes of poorly controlled asthma," writes the author of an accompanying editorial.

Prescription Med Use in Children Down Overall From 1999 to 2014

May 16, 2018

Asthma medications, antibiotics, attention-deficit/hyperactivity disorder (ADHD) medications, topical agents, and antihistamines were the most commonly used medication classes in 2011 to 2014.