Respiratory Disorders

Regeneron to Discontinue Development of RSV Treatment

By August 14, 2017

The primary endpoint of RSV prevention - assessed through day 150 of treatment - was not significantly reached.

Is Azithromycin Beneficial Post-Hematopoietic Stem Cell Transplant?

August 09, 2017

The researchers found that the 2-year airflow decline-free survival was 32.8 and 41.3% with azithromycin and placebo, respectively (unadjusted hazard ratio, 1.3).

Asthma Treatments: Inhalations

August 08, 2017

Inhalation doses for the treatment of asthma and prevention of exercise induced bronchospasm (EIB).

Fluticasone Furoate Slows Lung Function Decline in COPD

August 04, 2017

The researchers found that FF-containing regimes had lower rates of decline than placebo (P<0.03), and FF/VI had lower rates of decline than VI alone (P<0.005).

Guaifenesin/Pseudoephedrine Intervention May Cut Antibiotic Rxs for Acute URTI

By August 03, 2017

Results found that at day 8 of the study, a significantly lower amount of patients receiving guaifenesin/pseudoephedrine desired antibiotics compared to placebo, 4.2% vs. 8.0%, respectively.

'Overfat' Pandemic Grows Even as Obesity Rates Level Off

July 25, 2017

Traditional methods of measuring weight or body mass index are ineffective in assessing whether a person is overfat, the study authors said.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

Capsaicin Nasal Spray Evaluated in Patients with Mixed Rhinitis

July 20, 2017

"In conclusion, the capsaicin nasal spray is effective in a broader group of IR than the purely selected ones described before," the authors wrote.

Study Shows Zero Occurrences of Stethoscope Hygiene Between Patients

By July 19, 2017

Even after the intervention, of 41 subsequent observations, the researchers still noted zero occurrences of stethoscope hygiene. Hand hygiene did increase but only slightly, to 63%.

Investigational Nebulized LAMA Shows Promise in COPD Trial

By July 19, 2017

Results found that rates of COPD exacerbations were lowest in the 175mcg treatment arm. Also, the adverse events and serious adverse events in the revefenacin group were comparable to the tiotropium group.

Probiotics Show Little Efficacy in Protecting Infants

July 06, 2017

The average number of days missed was 11 for both groups. And based on parents' daily reports, there were no differences in cold symptoms, diarrhea, fever, or vomiting.

Does Asthma Inadvertently Protect Against Life-Threatening Infections?

June 23, 2017

The researchers found that patients with asthma had decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock (adjusted odds ratios, 0.41, 0.60, 0.59, 0.60, and 0.74, respectively) across all infections in the 2012 NIS data.

Genetics Should Play a Bigger Role in Clinical Decision-Making

June 21, 2017

As home genetic testing grows, patients will be bringing their results to physicians for reaction and response. Physicians will need to be proactively prepared.

Old Anti-Nausea Agent May Be Effective for Sleep Apnea

By June 07, 2017

"Expanded and pivotal clinical trials must still be conducted to fully establish the best approach to cannabinoid therapy in obstructive sleep apnea," said lead author Professor David Carley.

Review: Preventing the Common Cold with Vaccines

By June 06, 2017

Researchers found no statistically significant difference in common cold incidence with adenovirus vaccine versus placebo.

Diagnostic Patch Effectively IDs Sleep Apnea

By June 05, 2017

This lightweight skin-adhesive diagnostic patch is able to record nasal pressure, blood oxygen saturation, pulse, respiratory effort, sleep time, and body position.

CVD Comorbidity May Influence Bronchodilator Prescribing in COPD

By June 02, 2017

Given the potential cardiovascular side effects associated with bronchodilators, clinicians may be hesitant to prescribe the therapy to COPD patients with CVD.

Contraceptive ID'd as Culprit in Patient with Shortness of Breath, Chest Pain

By May 30, 2017

While IUD displacement has been discussed in the literature, the authors could not find a similar case which showed a displaced IUD reaching the diaphragm and causing chest pain.

Case: Inhaled Corticosteroid-Induced Myopathy in HIV Patient

By May 26, 2017

Initially, the team attributed the muscle weakness to either HIV or drug-mediated myopathy but a muscle biopsy later revealed atrophy of type II fibers without necrosis or inflammation.

Can IV Acetaminophen Reduce Post-Op Pain in Sinus Sx?

May 26, 2017

The results showed immediate relieve for the treatment group but as time went on the placebo group actually showed greater meaningful reductions in pain.

Severe Bronchial Injury Following Iron Pill Aspiration

By May 25, 2017

The patient presented to the emergency department 12 hours after choking while taking her iron supplement.

P2X3 Receptor Antagonist Investigated for Chronic Cough

By May 24, 2017

Results, measured by a recording device, found that those in the 50mg MK-7264 group had a statistically significant reduction in cough frequency of 37% when compared with placebo.

New Supplement Available for Relief of Allergy Symptoms

By May 24, 2017

In aclinical trial, AllerVarx decreased total symptom scores by ~70% and decreased the use of anti-allergic meds by ~73%.

Utibron Neohaler Reduces Nighttime Symptoms, Improves Lung Function in COPD Studies

By May 23, 2017

Two additional pooled analyses of FLIGHT1 and FLIGHT2 showed that treatment with Utibron Neohaler led to significant reduction in total nighttime COPD symptoms score vs. placebo over 12 weeks.

Spiriva Respimat Improves Lung Function in Difficult-to-Treat Patients

By May 23, 2017

Post hoc analyses of some Phase 3 placebo-controlled studies showed that adding Spiriva Respimat improved peak FEV1(0-3h) and trough FEV1 across a range of baseline IgE levels and eosinophil counts.

Sinuva Implant for Chronic Sinusitis to Be FDA Reviewed

By May 23, 2017

The Sinuva implant releases mometasone furoate to the ethmoid sinus lining and is intended to treat chronic sinusitis patients who have recurrent sinus obstruction.

Drug-Induced Bronchospasm in Multiple Asthma Patients

By May 23, 2017

Cocaine is considered one of the most commonly abused drugs that could potentially induce acute respiratory failure.

Antibiotic Failure Rates Investigated in Community-Acquired Pneumonia

By May 22, 2017

The researchers found that the total treatment failure rate was 22.1%, defined as either the need to refill antibiotic prescriptions, antibiotic switch, ER visit or hospitalization within 30 days of receiving initial antibiotic prescription.

Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

By May 22, 2017

Nair, P, MD, PhD. Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma. DOI: 10.1056/NEJMoa1703501.

Benralizumab Use Cuts Need for Oral Steroids in Severe Asthma

By May 22, 2017

The primary endpoint was met with 75% of the benralizumab group reducing their OCS doses compared to 25% in the placebo group. Additionally, 52% of the benralizumab group who had optimized baseline OCS doses of ≤12.5mg/d were able to completely stop OCS use.