Respiratory Disorders

Higher RSV Hospitalization Risk in Preemies After 2014 Guidance

By October 18, 2017

A decline in immunoprophylaxis was associated with an increased risk of RSV hospitalization among infants 29-34 weeks gestational age who were <6 months of age for both commercial- and Medicaid-insured.

Chronic Obstructive Pulmonary Disease Treatments

October 16, 2017

List of FDA-approved medications used for the maintenance and treatment of chronic obstructive pulmonary disease (COPD).

AASM: Position Statement on Home Sleep Apnea Testing

By October 16, 2017

HSATs are ordered by healthcare providers to help diagnosis obstructive sleep apnea (OSA) in adults.

Standard Guidelines Needed for Pulmonary Fibrosis Assessment Test

October 13, 2017

Development of nuanced standards designed specifically for IPF are needed given that there is increasing evidence and experience with its use in clinical trials.

Removing Behavioral Interventions May Up Inappropriate Antibiotic Prescribing

October 11, 2017

The researchers found that the rate of inappropriate antibiotic prescribing decreased in control clinics from 14.2 to 11.8% during the post-intervention period (absolute difference, −2.4%).

New Implant Approved for Moderate to Severe Central Sleep Apnea

By October 10, 2017

The implantable device works by stimulating a nerve in the chest that is involved in transmitting signals to the diaphragm to stimulate breathing.

COPD Exacerbation Risk Reduced With LAMA Plus LABA

October 04, 2017

Also might result in greater improvement in FEV1 than LABA plus corticosteroids

Pneumococcal Vaccine Rates Assessed by Work-Related Asthma Status

September 28, 2017

The researchers found that 42% of the estimated 12 million ever-employed adults with current asthma had received a pneumococcal vaccine. The likelihood of receiving a pneumococcal vaccine was increased for adults with work-related asthma versus those with non-work-related asthma.

Linhaliq NDA Granted Priority Review

By September 25, 2017

Linhaliq was previously granted Qualified Infectious Disease Product (QIDP) Designation and Fast Track designation for NCFBE with lung infections with P. aeruginosa.

Asthma Drug Linked to Neuropsychiatric Adverse Events

By September 21, 2017

Results found that overall depression was the most commonly reported adverse event in the VigiBase group while headaches were the most frequent adverse event reported for the Dutch database.

Xhance Nasal Spray Approved to Treat Nasal Polyps

By September 20, 2017

Xhance was evaluated in five trials enrolling >1,500 adults.

Impact of CPAP Telemonitoring with Feedback on Adherence

September 19, 2017

"The use of CPAP telemonitoring with automated feedback messaging improved 90-day adherence in OSA patients," the authors wrote.

Single Inhaler Triple Therapy Approved for COPD

By September 18, 2017

Trelegy Ellipta combines fluticasone furoate, an inhaled corticosteroid with umeclidinium, an anticholinergic and vilanterol, a long-acting β2-adrenergic agonist (LABA).

Symbicort Gains Expanded COPD Indication

By September 14, 2017

The studies examined the efficacy of Symbicort pressurized metered dose inhaler (pMDI) 160/4.5mcg vs. formoterol 4.5mcg in reducing COPD exacerbations in adults with moderate to severe COPD.

Mepolizumab Evaluated in COPD with Eosinophilic Phenotype

September 12, 2017

The researchers found that the mean annual rate of moderate or severe exacerbations in the modified intention-to-treat population with an eosinophilic phenotype was 1.40 and 1.71 per year in the mepolizumab and placebo groups in METREX (rate ratio, 0.82; 95% confidence interval, 0.68 to 0.98; adjusted P=0.04).

Dupilumab Beneficial in Patients with Uncontrolled, Persistent Asthma

By September 12, 2017

Results found that at 52 weeks severe asthma attacks were reduced by 46% in the overall population for the 300mg dose group and by 60% and 67% among those patients with ≥150 eosinophilic cells/microliter or greater and ≥300 eosinophilic cells/microliter, respectively (P<0.001).

Handheld Pen Device Rapidly Detects Cancerous Tissue

By September 08, 2017

Researchers at the University of Texas, who developed the MasSpec Pen device, tested its capability on 20 thin tissue sections (including breast tissues, thyroid tissues, papillary thyroid carcinoma, and follicular thyroid adenoma tissues) and 253 human patient tissue samples (including lung, ovary, thyroid and breast samples) some normal and some cancerous.

Statin Use May Reduce Mortality Risk in COPD

September 08, 2017

Statin exposure associated with lower all-cause, pulmonary mortality

Tiotropium Evaluated in Mild to Moderate COPD

September 07, 2017

Daily inhaled dose tied to improvements in FEV1 compared to placebo

FDA Approves Inhaler Monitoring Device for Symbicort

By September 06, 2017

The SmartTouch for Symbicort is a monitoring device that is installed onto the patient's inhaler to track and improve medication adherence.

Race May Play Role in Antibiotic Rx Trends for Pediatric ARTI

September 06, 2017

The researchers found that 2.6% of the PED encounters for viral ARTIs resulted in patient receipt of antibiotics, including 4.3, 1.9, 2.6, and 2.9% of non-Hispanic white, non-Hispanic black, Hispanic, and other non-Hispanic children, respectively.

Do Oral Corticosteroids Reduce Symptom Duration in Acute Lower RTI?

August 23, 2017

The researchers found that the median duration of cough was 5 days in both the prednisolone and placebo groups (adjusted hazard ratio, 1.11; 95% confidence interval, 0.89 to 1.39; P=0.36).

FDA Panel Will Focus on Cough Medicine Use in Kids at Upcoming Meeting

By August 21, 2017

Specifically, this panel of independent experts will discuss the the benefits and risk associated with the use of these products in this patient population as well as current treatment practices.

Single-Inhaler Triple Tx Compared with ICS/LABA in Advanced COPD

August 21, 2017

The researchers found that the mean changes from baseline in forced expiratory volume in 1 second were 142 mL and −29 mL, for the triple therapy and ICS/LABA therapy groups, respectively.

Impact of PCT Testing on Antibiotic Prescribing Examined in COPD Patients

August 21, 2017

There was a weak negative association between the rate of PCT testing and risk-adjusted rates of antibiotic initiation (P=0.005), with each 10 point increase in the percentage of patients undergoing PCT testing associated with a 0.7% decline in risk-adjusted antibiotic use (P=0.001).

Obstructive Sleep Apnea and Elevated Blood Coagulability: Is There a Link?

August 18, 2017

Significant differences were identified in PT seconds for the control group versus the moderate and severe OSA groups (mean, 11.26 versus 10.74 and 10.67, respectively).

More Deaths Worldwide From COPD Than From Asthma, Says Study

August 18, 2017

More deaths due to COPD than asthma worldwide in 2015; increase in COPD deaths since 1990

Regeneron to Discontinue Development of RSV Treatment

By August 14, 2017

The primary endpoint of RSV prevention - assessed through day 150 of treatment - was not significantly reached.

NDA Submitted for Non-Cystic Fibrosis Bronchiectasis Treatment

By August 11, 2017

Linhaliq (previously known as 'Pulmaquin') consists of a mixture of liposome encapsulated and unencapsulated ciprofloxacin. Linhaliq has previously been granted Orphan Drug status for the management of bronchiectasis.

Is Azithromycin Beneficial Post-Hematopoietic Stem Cell Transplant?

August 09, 2017

The researchers found that the 2-year airflow decline-free survival was 32.8 and 41.3% with azithromycin and placebo, respectively (unadjusted hazard ratio, 1.3).