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REQUIP
Parkinsonism
Restless legs syndrome
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Drug Name:

REQUIP Rx

Generic Name and Formulations:
Ropinirole (as HCl) 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg, 5mg; tabs.

Company:
GlaxoSmithKline Pharmaceuticals



Therapeutic Use:

Indications for REQUIP:

Idiopathic Parkinson's disease.

Adult Dose for REQUIP:

Titrate gradually. Taking with food may reduce nausea. Initially 0.25mg 3 times daily, then increase by 0.25mg 3 times daily at 1-week intervals to 1mg 3 times daily to 4th week. May increase by 1.5mg/day at 1-week intervals up to 9mg/day, then by up to 3mg/day at 1-week intervals to max 24mg/day.

Children's Dose for REQUIP:

Not recommended.

See Also:

REQUIP XL

Pharmacological Class:

Dopamine agonist (non-ergot).

Warnings/Precautions:

See literature. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Dyskinesia. Sleep disorders. Severe renal or hepatic impairment. Severe cardiovascular disease. Hypertension. Changes in heart rate. Psychotic disorders. Avoid abrupt cessation (withdraw over 1 week). Elderly may have higher risk of hallucinations. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Consider reducing concomitant levodopa dose. Alcohol, other CNS depressants may be potentiated. Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).

Adverse Reactions:

Early parkinsonism (without levodopa): Nausea, somnolence (including sudden sleep onset), abdominal pain/discomfort, dizziness, headache, constipation; dyskinesia, vomiting, syncope, fatigue, dyspepsia, infections, pain, sweating, asthenia, edema, postural hypotension, hypertension, changes in heart rate, pharyngitis, confusion, hallucinations, abnormal vision, aggravated parkinsonism. Advanced disease (with levodopa): also arthralgia, tremor, anxiety, dry mouth, hypokinesia, paresthesia.

How Supplied:

Tabs—100; XL tabs (2mg, 4mg, 8mg)—30, 90; XL tabs (6mg, 12mg)—30

REQUIP

  • 1mg tablets (Qty:240)
  • appx. price $966.00
GoodRx

Indications for REQUIP:

Restless legs syndrome.

Adult Dose for REQUIP:

Titrate gradually. Taking with food may reduce nausea. Take once-daily 1–3 hrs before bedtime. Initially 0.25mg on Days 1 & 2, then 0.5mg on days 3–7, increase by 0.5mg/day at 1-week intervals to 3mg then may increase to 4mg after 1 week; max 4mg/day.

Children's Dose for REQUIP:

Not recommended.

See Also:

Pharmacological Class:

Dopamine agonist (non-ergot).

Warnings/Precautions:

See literature. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Hypertension. Changes in heart rate. Psychotic disorders. Sleep disorders. Severe renal or hepatic impairment. Severe cardiovascular disease. Avoid abrupt cessation (withdraw over 1 week). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Alcohol, other CNS depressants may be potentiated. Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).

Adverse Reactions:

Nausea, vomiting, somnolence, dizziness, fatigue, others.

How Supplied:

Tabs—100; Starter kit (0.25mg x 2 tabs, 0.5mg x 5 tabs, 1mg x 7 tabs)—1

REQUIP

  • 1mg tablets (Qty:240)
  • appx. price $966.00
GoodRx

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