ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

REQUIP
Parkinsonism
Restless legs syndrome
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

REQUIP Rx

Generic Name and Formulations:
Ropinirole (as HCl) 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg, 5mg; tabs.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for REQUIP:

Parkinson's disease.

Adult:

Titrate gradually. Initially 0.25mg 3 times daily, then increase by 0.25mg 3 times daily at 1-week intervals to 1mg 3 times daily to 4th week. May increase by 1.5mg/day at 1-week intervals up to 9mg/day, then by up to 3mg/day at 1-week intervals to max 24mg/day. ESRD on dialysis: initially 0.25mg 3 times daily; max 18mg/day.

Children:

Not established.

See Also:

REQUIP XL

Pharmacological Class:

Dopamine agonist (non-ergot).

Warnings/Precautions:

See full labeling. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Dyskinesia. Sleep disorders. Severe renal or hepatic impairment. Severe cardiovascular disease. Hypertension. Changes in heart rate. Psychotic disorders. Urges/compulsive behaviors. Monitor for melanoma; perform periodic skin exams. Fibrotic complications. Avoid abrupt cessation (withdraw over 1 week). Elderly may have higher risk of hallucinations. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Consider reducing concomitant levodopa dose. Alcohol, other CNS depressants may be potentiated. Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).

Adverse Reactions:

Early parkinsonism (without levodopa): Nausea, somnolence (including sudden sleep onset), abdominal pain/discomfort, dizziness, headache, constipation; dyskinesia, vomiting, syncope, fatigue, dyspepsia, infections, pain, sweating, asthenia, edema, postural hypotension, hypertension, changes in heart rate, pharyngitis, confusion, hallucinations, abnormal vision, aggravated parkinsonism. Advanced disease (with levodopa): also arthralgia, tremor, anxiety, dry mouth, hypokinesia, paresthesia.

How Supplied:

Tabs—100; XL tabs—30

REQUIP

  • 1mg tablets (Qty:30)
  • appx. price $140.00
GoodRx

Indications for REQUIP:

Restless legs syndrome.

Adult:

Titrate gradually. Take once-daily 1–3 hrs before bedtime. Initially 0.25mg on Days 1 & 2, then 0.5mg on Days 3–7, increase by 0.5mg/day at 1-week intervals to 3mg then may increase to 4mg after 1 week; max 4mg/day. ESRD on dialysis: initially 0.25mg once daily; max 3mg/day.

Children:

Not established.

Pharmacological Class:

Dopamine agonist (non-ergot).

Warnings/Precautions:

See full labeling. Consider discontinuing if excessive daytime sleepiness or if sudden onset of sleep during daily activities occurs. Monitor for drowsiness or sleepiness, and for orthostatic hypotension. Dyskinesia. Sleep disorders. Severe renal or hepatic impairment. Severe cardiovascular disease. Hypertension. Changes in heart rate. Psychotic disorders. Urges/compulsive behaviors. Monitor for melanoma; perform periodic skin exams. Fibrotic complications. Avoid abrupt cessation (withdraw over 1 week). Elderly may have higher risk of hallucinations. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Alcohol, other CNS depressants may be potentiated. Potentiated by ciprofloxacin, possibly other CYP1A2 inhibitors. May be antagonized by dopamine antagonists (eg, phenothiazines, butyrophenones, metoclopramide). Adjust ropinirole dose if estrogens are added or discontinued. Monitor with drugs that induce CYP1A2 (eg, cigarette smoke).

Adverse Reactions:

Nausea, vomiting, somnolence, dizziness, fatigue, asthenia, malaise; hallucinations, dyskinesia, augmentation and early-morning rebound.

How Supplied:

Tabs—100

REQUIP

  • 1mg tablets (Qty:30)
  • appx. price $140.00
GoodRx

Sign Up for Free e-newsletters