RELENZA
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Generic Name for RELENZA
Zanamivir 5mg/blister; dry pwd for oral inhalation; contains lactose.
Legal Classification:
Rx
Pharmacological Class for RELENZA
Neuraminidase inhibitor.
Manufacturer of RELENZA
GlaxoSmithKline Pharmaceuticals
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Indications for RELENZA
Treatment of uncomplicated acute illness due to influenza A and B virus in patients ≥7 years of age who have been symptomatic for no more than two days. Prophylaxis of influenza in patients ≥5 years of age.
Adults and Children:
Use supplied Diskhaler inhalation device. Complete course of treatment. Treatment: <7yrs: not recommended. ≥7yrs: 2 inh (10mg total) twice daily (at least 2 hrs apart) on 1st day; then 2 inh (10mg total) twice daily at 12-hr intervals for the next 4 days (5 days total). Prophylaxis: <5yrs: not recommended. ≥5yrs: 2 inh (10mg total) once daily. Household: use for 10 days. Community: use for 28 days.
Precautions for RELENZA
Underlying airway disease (eg, asthma, COPD): not recommended; if used, patient must have a fast-acting bronchodilator available. Discontinue if bronchospasm or decline in respiratory function occurs or worsens. Monitor for signs of abnormal behavior (esp. in children). Pregnancy (Cat.C). Nursing mothers (unknown if drug excreted in milk).
Interactions for RELENZA
If an inhaled bronchodilator is scheduled for dosing at the same time, use the bronchodilator first. Caution with influenza virus vaccine live, intranasal (eg, FluMist); separate dosing by at least 48hrs before or 2 weeks after FluMist. May maintain normal influenza virus vaccine schedule.
Adverse Reactions for RELENZA
GI upset, sinusitis, dizziness, headache, bronchitis, cough, nasal symptoms, respiratory function decline (eg, bronchospasm, dyspnea), allergic reactions (eg, oropharyngeal edema), possible neuropsychiatric events (eg, seizures, confusion, abnormal behavior).
How is RELENZA supplied?
4 blisters/Rotadisk—5 Rotadisks/box (w. 1 Diskhaler)
Related Disease:
Influenza~antivirals