Psychiatric Disorders

Can Omega-3 Fatty Acid Monotherapy Effectively Treat Adolescent Depression?

July 20, 2018

These results challenge existing conceptions that omega-3 fatty acids may be effective in treating adolescent major depressive disorder.

Withdrawal Symptoms Following SNRI Discontinuation Investigated

By July 19, 2018

Results showed that discontinuation of any SNRI was associated with withdrawal symptoms, with the highest prevalence linked to venlafaxine and desvenlafaxine.

High Frequency of Digital Media Use May Lead to Development of ADHD Symptoms

July 18, 2018

There was a correlation for high-frequency engagement in each additional digital media activity at baseline with a significantly increased odds of having ADHD symptoms across follow-up (odds ratio, 1.11).

Physician Burnout Tied to Higher Risk of Medical Errors

July 17, 2018

Physicians reporting errors were more likely to also report burnout, fatigue, recent suicidal ideation

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

By July 16, 2018

Currently, there are no approved treatments for behavioral symptoms (eg, aggression, agitation) in Alzheimer's disease.

NDA for ADHD Med That Is Dosed at Night Resubmitted to FDA

By July 12, 2018

HLD200 is a delayed-release and extended-release formulation of methylphenidate.

FDA Strengthens Warnings for Fluoroquinolone Antibiotics

By July 10, 2018

The labeling changes are based on a review of postmarketing adverse event reports found in the FDA Adverse Event Reporting System (FAERS) database and published medical literature.

Blister Packs for Several Meds Recalled Due to Risk of Harm to Children

By July 09, 2018

The recall affects approximately 470,000 units that include drugs packaged with 3 to 10 tablets per blister card. The blister packs were developed for use in hospitals, however some were sent to retail pharmacies and were likely dispensed for in-home use.

Atypical Antipsychotic Use and CV Events in Youth: What's the Link?

By July 06, 2018

The retrospective cohort study involved a search of Medicaid claims of pediatric patients aged 5 to 20 years who were initiated on atypical antipsychotic medications.

Aristada Initio Regimen Approved for Initiation of Schizophrenia Treatment

By July 02, 2018

Prior to this approval, the Aristada initiation regimen consisted of taking oral aripiprazole for 21 consecutive days starting with the first Aristada dose.

FDA Approves New Nuplazid Formulation, Dosage Strength

By June 29, 2018

Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.

Early Preterm Birth Linked to Increased ADHD Symptoms

June 26, 2018

The correlation between gestational age at birth and symptoms of ADHD in preschool and school-age children was compared after adjustment for unmeasured genetic and environmental risk factors.

Efavirenz Use and Depression, Suicidal Ideation: Is There a Link?

June 26, 2018

The researchers found that depression or suicidal ideation did not differ at baseline for patients ever exposed to efavirenz versus those never exposed to efavirenz and receiving nevirapine.

Risk of OD Highest for First Days of Opioid + Benzodiazepine Use

June 25, 2018

The highest risk of overdose was seen on the first days of concurrent opioid and benzodiazepine use, with a decrease in risk over time.

Prenatal antidepressant exposure may increase risk of poor motor development

June 21, 2018

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Some Neonatal Risks for Lithium Exposure in Pregnancy

June 20, 2018

Compared with the reference group, lithium-exposed pregnancies had an increased risk for neonatal readmission (27.5 vs 14.3%; pooled adjusted odds ratio, 1.62).

Cannabis Use Linked to Psychosis Symptoms in Adolescents

June 19, 2018

These correlations were similar in size to the autoregressive link between PS from ages 15 to 16. There was a statistically significant association for PS at age 15 years with cannabis use at age 16 years.

Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants

By June 18, 2018

Within the cohort, 3838 cases were identified and compared with 38,380 age-matched controls.

Medications with depression as a possible adverse effect associated with increased risk

June 15, 2018

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

AMA President Calls Physicians to Lead in Addressing Gun Violence

June 14, 2018

For decades the AMA has demonstrated leadership on this issue, recommending common-sense gun safety precautions, waiting periods and background checks for those wishing to purchase a gun, and increased mental health service funding.

Antipsychotic Tx Linked to Adiposity Changes in Youths

June 14, 2018

The researchers found that from baseline to week 12, the dual-energy X-ray absorptiometry percentage total body fat increased by 1.18, 4.12, and 1.66% for risperidone, olanzapine, and aripiprazole, respectively, and was significantly greater for olanzapine than risperidone or aripiprazole.

Acute Insomnia Found to Be Common Among Good Sleepers

June 14, 2018

Over 1 year, subjects who were recruited and corroborated as good sleepers were monitored with daily sleep diaries. Regular assessments of participants' daytime function, stress and life events, and medical and mental health were made.

APA: Suicide Prevention Should Be a Public Health Priority

June 14, 2018

The APA is highlighting the need for more funding for evidence-based treatment and its dissemination, including crisis services, as well as more research focused on risk assessment, evidence-based prevention programs, and treatment to reduce the incidence of suicide.

Work Stress May Increase Risk of Developing Atrial Fibrillation

June 13, 2018

The researchers found that job strain was associated with an almost 50% increased risk of atrial fibrillation (hazard ratio [HR], 1.48; 95% confidence interval, 1.00 to 2.18) after adjustment for age, sex, and education.

Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child

June 13, 2018

The researchers found that 11 of 20 studies that reported estimates for ASD (777,518 participants) found higher odds with HDP (adjusted odds ratio [aOR], 1.35) in pooled analysis. For the 6 studies reporting adjusted estimates of ADHD (1,395,605 participants), the pooled adjusted OR was 1.29.

Medications With Depression as Adverse Side Effect Commonly Used

June 13, 2018

The number of medications used with depression as a possible adverse effect correlated with increased prevalence of concurrent depression, in analyses excluding antidepressant users.

Suicide Rates On the Rise in Nearly Every State, Says New CDC Report

By June 08, 2018

Using data from the National Vital Statistics System, the CDC researchers examined trends in age-adjusted suicide rates in individuals 10 years of age and older, by state and sex, across 6 consecutive 3-year periods (1999-2016).

Prostate Cancer Treatment Side Effects Linked to Distress

June 08, 2018

This relationship was bidirectional, with men who reported worse distress also subsequently reporting worse urinary, bowel, and sexual functions.

Older Age Tied to Poorer Course of Major Depressive Disorder

June 08, 2018

Results were slightly attenuated but remained mostly significant with adjustment for prognostic factors

Why Medicine Leads the Professions in Suicide, and What We Can Do About It

June 06, 2018

One recent survey found that 42% of US physicians are burned out, with rates of 38% among men and 48% among women. The authors here suggest that clinicians are encouraged to care for human beings, not merely to manage health information.