Psychiatric Disorders

ADHD Incidence Increases Significantly Following Childhood TBI

March 20, 2018

The researchers found that 25.7% of the 187 children met the definition of SADHD. Compared with the OI group, severe TBI correlated with SADHD (hazard ratio [HR], 3.62; 95% confidence interval [CI], 1.59 to 8.26).

SSRIs vs SNRIs: Efficacy Compared for Pediatric Anxiety Disorders

By March 19, 2018

The authors noted that treatment with SSRIs led to significantly greater improvement by the second week of treatment vs. SNRIs (P=0.0268); this benefit remained statistically significant through Week 12.

High School Peer-to-Peer Program May Increase Early Depression Detection

March 19, 2018

The researchers found that after implementation of the campaigns, students had improved knowledge and attitudes toward depression, increased confidence in identifying and referring peers with depression, improved help-seeking intentions, and reduced stigma.

Incidence of Breast Cancer Investigated Among Women With Schizophrenia

March 16, 2018

The researchers included 12 cohorts (760 women) in this meta-analysis. Pooled analysis showed that schizophrenia was associated with a significantly increased risk of breast cancer incidence in women (SIR, 1.31; P<0.001).

Does Oseltamivir Use Increase the Risk of Suicide in Pediatric Patients?

By March 13, 2018

To investigate a possible relationship, researchers from the University of Illinois and the Children's Hospital University analyzed 21,407 suicide-related events among 1 to 18 year old individuals.

Teens With Mental Health Conditions More Likely to Receive Opioids Long-Term

March 13, 2018

Teens with pre-existing mental health conditions, tx more likely to transition to long-term opioid use

Lemborexant, Zolpidem ER Go Head-to-Head in Sleep Disorder Study

By March 07, 2018

In the Phase 3 SUNRISE 1 study, lemborexant achieved its primary and key secondary objectives vs. placebo and vs. zolpidem tartrate extended-release (active comparator) in patients aged ≥55 years with difficulty staying asleep through the night.

Latuda Indication Expanded to Treat Pediatric Bipolar Depression

By March 07, 2018

Latuda's (lurasidone HCI; Sunovion) expanded indication has been approved for pediatric patients aged 10 to 17 years who have major depressive episodes associated with bipolar I disorder.

Treatment Shows Promise for Delirium Prevention in Critically Ill

March 05, 2018

The researchers found that nocturnal dexmedetomidine was associated with a greater proportion of patients who remained delirium-free during the ICU stay (relative risk, 0.44; P=0.006).

FDA Accepts Solriamfetol NDA for Narcolepsy-, OSA-Related Sleepiness

By March 02, 2018

Solriamfetol is a selective dopamine and norepinephrine reuptake inhibitor.

Progestin-Only Contraceptives and Depression: Is There a Link?

By February 28, 2018

Study quality was graded according to the United States Preventive Services Task Force and the Cochrane Risk of Bias Tools.

Serotonin Syndrome Risk Assessed With Concomitant Triptan, SSRI/SNRI Use

February 27, 2018

Researchers question FDA advisory warning on risk of concomitant use

Off-Label Baclofen Use for Alcohol Use Disorders: Is it Effective?

By February 26, 2018

Data showed a significant effect on abstinence rates with the use of baclofen (odds ratio [OR] 2.67, 95% CI: 1.03, 6.93) but no other significant effects on treatment efficacy (heavy drinking days SMD -0.26, 95% CI: -0.68, 0.15) or mechanism of action (craving SMD: -0.13, 95% CI: -0.36, 0.09) were seen.

Can Diet Adherence Help Cut Depression Risk in Adults?

By February 26, 2018

The results showed that those participants who fell into the top group for DASH diet adherence had 11% lower odds of becoming depressed versus those in the lowest group of DASH adherence.

Adzenys ER Oral Suspension Launched for ADHD

By February 26, 2018

The once-daily medication uses the same modified-release drug delivery technology seen in Adzenys XR-ODT (amphetamine) Extended-Release Orally Disintegrating Tablets.

Adolescent Depression Identification, Initial Management Guidelines Updated

February 26, 2018

This updated to guidelines is used to address practice preparation, identification, assessment, and initial management of adolescent depression.

Has Benzodiazepine Use Declined in Those Over 65?

February 26, 2018

There were significant declines in prevalent use in the U.S. Incidence and prevalence also decreased with age.

Can Haloperidol Help Survival in Critically Ill Who Are At-Risk of Delirium?

February 22, 2018

There was no statistically significant difference in any of the 15 secondary outcomes, including delirium incidence, delirium-free and coma-free days, and duration of mechanical ventilation, ICU, and hospital length of stay.

Antidepressants Compared and Ranked for Treatment of Major Depressive Disorder

February 22, 2018

Researchers found that in head-to-head studies, the most effective antidepressants were agomelatine, amitriptyline, escitalopram, mirtazapine, paroxetine, venlafaxine, and vortioxetine, while the least efficacious were fluoxetine, fluvoxamine, reboxetine, and trazodone.

Connections Between Depression Severity and HIV Treatment Failure Explored

February 22, 2018

During follow-up, 18.8% of scheduled visits were missed, 21.8% of viral loads were detectable, and the mortality rate was 1.5 deaths for 100 person-years; a dose-response relationship was seen for percentage of days with depression in each outcome.

New Test May Help Diagnose Autism Earlier in Children

By February 20, 2018

In this study, researchers explored the association of proteotoxic damage with autism spectrum disorder.

Pimavanserin Evaluated in Patients With Alzheimer's Disease Psychosis

February 15, 2018

By week 12, for the overall population there was no significant advantage for pimavanserin versus placebo (treatment difference, −0.51; 95% CI, −2.23 to 1.21; P=0.561). Common adverse events in both groups included falls, urinary tract infections, and agitation.

Is There Any Link Between Ultrasound Exposure and Autism?

February 14, 2018

The ASD group had a shorter duration of ultrasound exposure than the typical development group during the first (290.4 versus 406.4 seconds) and second (1,687.6 versus 2,011 seconds) trimesters. Greater mean depth of ultrasonographic penetration was seen in the ASD group versus the developmental delay group in the first trimester (12.5 versus 11.6 cm).

CDC: Prevalence of Depression Examined Among U.S. Adults

February 14, 2018

Depression more common in women; lower among non-Hispanic Asians than other ethnic groups

Addressing Sensitive Topics With Patients: An Interview With Windel Stracener, MD

By February 14, 2018

"Patients must feel that you are empathetic and do not judge them. This is key not only to discussing weight, but to any subject that comes up," said Dr Windel Stracener, a family practitioner for 22 years.

Depression Treatment Initiation Among Newly Diagnosed 'Suboptimal', Says Study

By February 13, 2018

A total of 241,251 adults with newly diagnosed depression were assessed for this study.

Cognitive Enhancement Therapy May Benefit Adults With Autism

February 13, 2018

Participants treated with CET were significantly more likely to gain competitive employment

Is Cranial Electrical Stimulation Effective for Pain, Depression, Anxiety?

February 13, 2018

In patients with anxiety and depression, low-strength evidence of a possible modest benefit was seen in 4 trials conducted more than 40 years ago and in one recent trial compared with sham treatments.

Prazosin and placebo exhibit similar efficacy in post-traumatic stress disorder: The PACT trial

February 12, 2018

In patients with nocturnal symptoms of post-traumatic stress disorder (PTSD), prazosin did not significantly reduce nightmares or improve quality of sleep compared to placebo at 10 or 26 weeks.

Virtual Reality-Based CBT May Benefit Patients With Psychotic Disorders

February 12, 2018

VR-CBT in addition to standard treatment can reduce paranoid ideation, momentary anxiety