PROZAC ORAL SOLUTION

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Generic Name for PROZAC ORAL SOLUTION Fluoxetine (as HCl) 20mg/5mL; mint flavor. Legal Classification: Rx Pharmacological Class for PROZAC ORAL SOLUTION SSRI. Manufacturer of PROZAC ORAL SOLUTION Dista Products Company

Indications for PROZAC ORAL SOLUTION

Monotherapy: major depressive disorder (MDD); or bulimia nervosa. In combination with olanzapine: depressive episodes associated with bipolar disorder, or treatment resistant depression (TRD; see literature).

Adult dose for PROZAC ORAL SOLUTION

MDD: initially 20mg daily in AM; increase if needed after several weeks. May give doses >20mg/day in 2 divided doses (AM and noon); max 80mg/day. Bulimia: 60mg once daily in the AM; may titrate to this dose. Bipolar depression: initially olanzapine 5mg + fluoxetine 20mg once daily in the PM; range: olanzapine 5–12.5mg + fluoxetine 20–50mg. TRD: initially olanzapine 5mg + fluoxetine 20mg once daily in the PM; range: olanzapine 5–20mg + fluoxetine 20–50mg. Risk of hypotension, hepatic impairment, slow metabolizers, or sensitive to olanzapine: initially olanzapine 2.5–5mg + fluoxetine 20mg; increase cautiously. Hepatic impairment (reduce dose), dose adjustments: see literature.

Children's dosing for PROZAC ORAL SOLUTION

<8yrs: not recommended. 8–17yrs: MDD: initially 10mg or 20mg/day; if started on 10mg/day, increase after 1 week to 20mg/day. Lower weight children: start at 10mg/day; may increase after several weeks to 20mg/day.

Also:

Contraindications for PROZAC ORAL SOLUTION

During or within 14 days of MAOIs. Concomitant pimozide, thioridazine (may cause QTc prolongation).

Precautions for PROZAC ORAL SOLUTION

Monitor for serotonin syndrome or neuroleptic malignant syndrome-like signs/symptoms; discontinue if occurs. Discontinue if unexplained allergic reaction occurs. Renal or hepatic dysfunction. History of seizures or mania/hypomania. Recent MI. Unstable heart disease. ECT (prolonged seizures). Reevaluate periodically in long-term use. Avoid abrupt cessation. Monitor weight. Conditions that affect metabolism or hemodynamic responses. Volume depletion. Diabetes. Suicidal tendencies (monitor). Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C; avoid 3^rd trimester or consider lower dose; see literature for effects on neonate). Nursing mothers: not recommended.

Interactions for PROZAC ORAL SOLUTION

See Contraindications. Do not start MAOI or thioridazine within at least 5 weeks of discontinuing fluoxetine. Concomitant SSRIs, SNRIs, tryptophan: not recommended. May potentiate protein-bound drugs (eg, warfarin, digoxin) and those metabolized by CYP2D6 (eg, tricyclics, vinblastine, flecainide). May potentiate carbamazepine, phenytoin. Monitor lithium, phenytoin, warfarin, tricyclics. Caution with benzodiazepines (eg, diazepam, alprazolam), antipsychotics (eg, clozapine, haloperidol), other CNS drugs. Increased risk of bleeding with NSAIDs, aspirin, warfarin, others that affect coagulation. Caution with triptans, linezolid, lithium, tramadol, St. John's wort; may cause serotonin syndrome (eg, weakness, incoordination, hyperreflexia). Hyponatremia with diuretics.

Adverse Reactions for PROZAC ORAL SOLUTION

Nausea, CNS stimulation (eg, anxiety, nervousness, insomnia), somnolence, headache, mania/hypomania, anorexia, weight loss, tremor, asthenia, sexual dysfunction, sweating, GI disturbances, respiratory symptoms, motor impairment, serum sickness, hypo- or hyperglycemia, rash (may be serious), urticaria, pruritus; rarely: platelet dysfunction. Children: thirst, hyperkinesia, agitation, personality disorder, epistaxis, urinary frequency, menorrhagia.

How is PROZAC ORAL SOLUTION supplied?

Caps 10mg—100
20mg—30, 100, 2000
40mg—30
Liq—4oz
Weekly—4

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