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PROTONIX TABLETS
Hyperacidity, GERD, and ulcers
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Drug Name:

PROTONIX TABLETS Rx

PROTONIX TABLETS (pantoprazole [as sodium]) 20mg, 40mg e-c delayed-release tablets by Pfizer

Generic Name and Formulations:
Pantoprazole (as sodium) 20mg, 40mg; e-c delayed-release tabs.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts

Therapeutic Use:

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Indications for PROTONIX TABLETS:

Short-term treatment and maintenance of healing of erosive esophagitis (EE). Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).

Adult Dose for PROTONIX TABLETS:

Swallow whole. Do not crush or chew granules. Susp: Take 30mins before a meal. Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). Treatment of EE: 40mg once daily for ≤8 weeks; if not healed, may repeat for 8 more weeks. Maintenance of EE healing: 40mg once daily. Pathological hypersecretory conditions: initially 40mg twice daily; max 240mg/day.

Children's Dose for PROTONIX TABLETS:

Swallow whole. Do not crush or chew granules. Susp: Take 30mins before a meal. Mix contents of packet in 5mL of apple juice or applesauce (do not mix in water, other liquids or foods); then swallow. May give via NG tube (see literature). <5yrs: not recommended. Treatment of EE: Give once daily for up to 8 weeks. ≥5yrs: (≥15kg to <40kg): 20mg; (≥40kg): 40mg.

See Also:

PROTONIX for ORAL SUSP

PROTONIX I.V.

Pharmacological Class:

Proton pump inhibitor.

Warnings/Precautions:

Gastric malignancy. Increased risk of osteoporosis-related fractures of the hip, wrist or spine with long-term and multiple daily dose PPI therapy. Monitor magnesium levels with long-term therapy. Reevaluate periodically. IV: consider zinc supplementation in those prone to zinc deficiency. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Concomitant atazanavir or nelfinavir: not recommended. May alter absorption of gastric pH-dependent drugs (eg, ketoconazole, iron, ampicillin). Concomitant digoxin or drugs that may cause hypomagnesemia (eg, diuretics); consider monitoring magnesium levels. Monitor warfarin. May give antacids concomitantly. IV: caution with concomitant other EDTA-containing products. May potentiate methotrexate. May cause false (+) urine THC test.

Adverse Reactions:

Headache, GI upset, dizziness, arthralgia, inj site reactions; also children: upper respiratory infection, fever, rash, abdominal pain; rare: cyanocobalamin deficiency, hypomagnesemia (w. prolonged PPI therapy), possible C. difficile associated diarrhea.

Metabolism:

Hepatic (CYP2C19, 3A4). 98% protein bound.

Elimination:

Renal (primarily), fecal.

Generic Availability:

Tabs, IV (YES); oral soln (NO)

How Supplied:

Tabs—90; Susp—30 packets/box; Vials (40mg)—10, 25