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Miscellaneous Ob/Gyn conditions
Only 4 drugs may be compared at once

Generic Name and Formulations:

Dinoprostone 20mg; per vaginal suppository.


Pfizer Inc.

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Indications for PROSTIN E2:

For the termination of pregnancy from the 12th through the 20th gestational weeks. For the evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age. Management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).


Insert one supp high into vagina. Remain in supine position for 10mins following insertion. May insert subsequent supp at 3–5hr intervals until abortion occurs. Continuous administration for more than 2 days is not recommended.


Not established.


Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.


Not indicated if fetus in utero has reached the stage of viability. Not for use in cervical ripening or other indication in patients with term pregnancy. Asthma. Hypo-or hypertension. Anemia. Jaundice. Diabetes. Epilepsy. History of cardiac, renal, or hepatic disease. Cervicitis. Infected endocervical lesions. Acute vaginitis. Compromised (scarred) uteri. Remove supp if hypersensitivity reaction is suspected. Pregnancy.


Concomitant other oxytocic agents: not recommended.

Pharmacological Class:

Prostaglandin E2.

Adverse Reactions:

Vomiting, transient pyrexia (see full labeling re: PGEs induced pyrexia vs. endometritis pyrexia), diarrhea, nausea, headache, chills, transient decrease in BP; MI in patients with history of CVD, hypersensitivity.

How Supplied: