Prostate And Other Male Cancers
Within 4 months of enzalutamide initiation, four patients (1.1%) had at least one confirmed seizure; three additional patients (0.8%) experienced a seizure within four months following the 4-month study period.
Apalutamide, an investigational, next generation oral androgen receptor inhibitor, was assessed for safety and efficacy in the Phase 3 pivotal trial, ARN-509-003 (SPARTAN), which the NDA is based on.
Alternative medicine was independently associated with greater risk of death compared with conventional cancer treatment overall (hazard ratio [HR], 2.50), as well as in subgroups with breast (HR, 5.68), lung (HR, 2.17), and colorectal cancer (HR, 4.57).
As home genetic testing grows, patients will be bringing their results to physicians for reaction and response. Physicians will need to be proactively prepared.
Researchers of 2 newly published studies found that abiraterone (Zytiga) lowers risk of death by nearly 40% when added to standard androgen deprivation therapy.
In the per-protocol analysis, the researchers found that the average survival after surgery for those receiving capecitabine was 53 months, compared to 36 months for those who only had surgery. Existing Treatment Should be Considered Standard of Care in Biliary Cancer
For breast cancer, the diagnosis of early disease increased from 47.8 to 48.9%. For colorectal cancer it rose from 22.8 to 23.7%. And for lung cancer from 16.6 to 17.7%.
The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.
Nearly 7,000 Italian men participating in the Moli-sani epidemiological study aged ≥50 years were monitored for an average of 4.25 years.
The USPSTF performed a systematic review of the existing evidence and concluded that the potential benefits and harms of prostate-specific antigen (PSA)-based screening are "closely balanced" in men aged 55-69 years.
The researchers found that survival curves showed that metformin use with docetaxel did not significantly improve prostate cancer-specific survival.
These studies identified links to increased risks of thyroid, testicular and breast cancer, nonalcoholic fatty liver disease and even the early onset of puberty for boys, which can lead to diseases in adulthood.
Six hours of sleep a night was linked to a 29% higher risk of prostate cancer death compared to 7 hours. Men who were 65 or older showed no difference in the risk of death from prostate cancer.
The researchers found that regular aspirin use correlated with reduced risk of total mortality compared with nonregular use (multivariable-adjusted relative risks [RRs], 0.93 and 0.89 for women and men, respectively).
The detection rate of high-grade prostate cancer was comparable for 6-TRUS-Bx, 12-TRUS-Bx, and MRI ± TBx; 10, 12, and 11%, respectively.
Study authors identified a total of 8,545 patients undergoing 73,577 administrations of chemotherapy with minimal or low emetic risk.
The researchers found that the adjusted mean sexual domain score decreased more for radical prostatectomy than for EBRT at three years.
For men with high serum prostate-specific antigen, multi-parametric magnetic resonance imaging (MP-MRI) is more sensitive but less specific than transrectal ultrasound guided prostate biopsy (TRUS-biopsy) for detecting clinically significant cancer, and can be used as a triage test to avoid unnecessary biopsy, according to a study published online in The Lancet.
Prolonged work-related stress in men has been tied to increased chances of cancer at five sites; lung, colon, rectal, stomach and lymphatic.
Use of zoledronic acid every 12 weeks does not result in increased risk of skeletal events compared with use every four weeks among patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma, according to a study published in the January 3 issue of the Journal of the American Medical Association.
The rate of germline BRCA1/2 and ATM mutations is significantly higher among patients with lethal prostate cancer (PCa) and is an independent predictor of lethal PCa, according to a study published online December 15 in European Urology.
Magnetic resonance imaging (MRI) and MRI-targeted biopsies have a role in the diagnosis and treatment of patients with a prior negative prostate biopsy, according to a review published in the December issue of The Journal of Urology.
For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online in the Journal of Clinical Oncology.
In a consensus statement from the American Urological Association and Society of Abdominal Radiology, published in The Journal of Urology, guidelines are presented for prostate magnetic resonance imaging (MRI) in patients with negative biopsy.