Propranolol/Hydrochlorothiazide Rx

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Generic Name and Formulations:

Propranolol HCl, hydrochlorothiazide; 40mg/25mg; scored tabs.

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Indications for Propranolol/Hydrochlorothiazide:



Titrate individual components.


Not recommended.


Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.


Overt heart failure. Ischemic heart disease. Wolff-Parkinson-White syndrome. Bronchospasm, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Noncardioselective beta-blocker + diuretic.


Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Potentiates antipyrine, lidocaine, nondepolarizing muscle relaxants, theophylline. Adjust antidiabetic medication. May increase cardiac effects of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid, glaucoma screening tests. May block epinephrine.

Adverse Reactions:

Heart failure, bronchospasm, bradycardia, heart block, fatigue, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, orthostatic hypotension, dizziness, GI upset, depression, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), photosensitivity, pharyngitis, agranulocytosis.


Formerly known under the brand name Inderide.

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