Generic Name and Formulations:
Promethazine HCl 12.5mg+, 25mg+, 50mg; tabs; +scored.
Various generic manufacturers
Motion sickness. Perioperative nausea & vomiting.
Motion sickness: 25mg 30–60 minutes before travel; may repeat in 8–12 hours; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6 hour intervals.
<2 years: see Contraindications. Motion sickness: ≥2 years: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6 hour intervals.
Children <2 years. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children.
Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2 years. Pregnancy (Cat.C). Nursing mothers: not recommended.
Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results.
Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal).
Formerly known under the brand names Phenergan (tabs, supps); Promethacon (supps).