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Promethazine HCl Injection

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Generic Name for Promethazine HCl Injection

Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.

Legal Classification:

Pharmacological Class for Promethazine HCl Injection

Phenothiazine.

Manufacturer of Promethazine HCl Injection

Various generic manufacturers

Indications for Promethazine HCl Injection

For light sedation and relief of apprehension. Obstetric (during labor), pre- and post-operative sedation.

Adult dose for Promethazine HCl Injection

Sedation: 25–50mg IM or IV. Obstetric: 50mg IM or IV in early stages of labor; 25–75mg IM or IV when labor is established; may repeat once or twice at 4 hour intervals; max 100mg/day. Pre- and post-op: 25–50mg IM or IV.

Children's dosing for Promethazine HCl Injection

<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).

Contraindications for Promethazine HCl Injection

Children <2 years. Coma. Intra-arterial or subcutaneous injection.

Warnings/Precautions for Promethazine HCl Injection

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions for Promethazine HCl Injection

Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.

Adverse Reactions for Promethazine HCl Injection

Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).

How is Promethazine HCl Injection supplied?

Contact supplier.

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