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Promethazine HCl Injection
Allergies
Nausea
Nonnarcotic analgesics
Sleep-wake disorders
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Drug Name:

Promethazine HCl Injection Rx

Generic Name and Formulations:
Promethazine HCl 25mg/mL, 50mg/mL; sol for IM or IV inj; contains sulfites.

Company:
Various generic manufacturers

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for Promethazine HCl Injection:

Allergic reactions to blood or plasma. Uncomplicated allergic conditions of the immediate type where oral therapy is impossible or contraindicated. Adjunct in anaphylaxis.

Adult Dose for Promethazine HCl Injection:

25mg IM or IV, if 2nd dose is needed, may repeat after 2 hours. Switch to oral form as soon as possible

Children's Dose for Promethazine HCl Injection:

<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).

Pharmacological Class:

Phenothiazine.

Contraindications:

Children <2 years. Coma. Intra-arterial or subcutaneous injection.

Warnings/Precautions:

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.

Adverse Reactions:

Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).

Note:

Formerly known under the brand name Phenergan.

How Supplied:

Contact supplier.

Indications for Promethazine HCl Injection:

Motion sickness. Prevention and treatment of nausea & vomiting with anesthesia and surgery.

Adult Dose for Promethazine HCl Injection:

12.5–25mg IM or IV every 4 hours.

Children's Dose for Promethazine HCl Injection:

<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature). Should not be used in vomiting of unknown etiology in children and adolescents.

Pharmacological Class:

Phenothiazine.

Contraindications:

Children <2 years. Coma. Intra-arterial or subcutaneous injection.

Warnings/Precautions:

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.

Adverse Reactions:

Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).

Note:

Formerly known under the brand name Phenergan.

How Supplied:

Contact supplier.

Indications for Promethazine HCl Injection:

Adjunct to analgesics for control of postoperative pain. Special surgical situations (i.e. bronchoscopy, ophthalmic surgery, poor risk patients) to reduce amounts of narcotic analgesic as an adjunct to anesthesia and analgesia.

Adult Dose for Promethazine HCl Injection:

25–50mg IM or IV.

Children's Dose for Promethazine HCl Injection:

<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).

Pharmacological Class:

Phenothiazine.

Contraindications:

Children <2 years. Coma. Intra-arterial or subcutaneous injection.

Warnings/Precautions:

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.

Adverse Reactions:

Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).

Note:

Formerly known under the brand name Phenergan.

How Supplied:

Contact supplier.

Indications for Promethazine HCl Injection:

For light sedation and relief of apprehension. Obstetric (during labor), pre- and post-operative sedation.

Adult Dose for Promethazine HCl Injection:

Sedation: 25–50mg IM or IV. Obstetric: 50mg IM or IV in early stages of labor; 25–75mg IM or IV when labor is established; may repeat once or twice at 4 hour intervals; max 100mg/day. Pre- and post-op: 25–50mg IM or IV.

Children's Dose for Promethazine HCl Injection:

<2yrs: see Contraindications. ≥2yrs: should not exceed half that of suggested adult dose (see literature).

Pharmacological Class:

Phenothiazine.

Contraindications:

Children <2 years. Coma. Intra-arterial or subcutaneous injection.

Warnings/Precautions:

Sulfite sensitivity. CNS depression. Impaired respiratory function (eg, COPD, sleep apnea). Narrow-angle glaucoma. GI or GU obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers: not recommended.

Interactions:

Potentiates CNS depression with alcohol, other CNS depressants. Caution with epinephrine, anticholinergics, MAOIs. May alter hCG pregnancy test results and glucose tolerance tests.

Adverse Reactions:

Inj site reactions, CNS depression/drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, neuroleptic malignant syndrome, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, dry mouth, paradoxical reactions; children: respiratory depression (may be fatal).

Note:

Formerly known under the brand name Phenergan.

How Supplied:

Contact supplier.

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