Indications for PRIVIGEN:
Primary immunodeficiency (eg, congenital agammaglobulinemia, X-linked agammaglobulinemia, common variable immunodeficiency, Wiskott-Aldrich syndrome, severe combined immunodeficiencies).
Adults and Children's Dose:
<3yrs: not recommended. ≥3yrs: Give by IV infusion at an initial rate of 0.5mg/kg/min, if tolerated may increase to 8mg/kg/min. Renal dysfunction, thrombosis risk: give at the minimum infusion rate practicable. Usual dose: 200–800mg/kg every 3–4 weeks. Adjust subsequent dose based on serum IgG trough levels and clinical response.
Pharmacological Class:
Immune globulin.
Contraindications:
IgA-deficiency with IgA antibodies. Hyperprolinemia.
Warnings/Precautions:
Correct volume depletion; assess renal function, BUN, serum creatinine, urine output before and during therapy; discontinue if renal function deteriorates. Diabetes, obese, hypovolemia: increased risk of renal dysfunction. History of atherosclerosis, multiple CV risk factors, advanced age, impaired cardiac output, coagulation disorders, prolonged immobilization, hyperviscosity: increased risk of thrombotic events; consider baseline assessment of blood viscosity for those at risk of hyperviscosity. Monitor for aseptic meningitis, hemolysis, delayed hemolytic anemia, transfusion-related acute lung injury (eg, respiratory distress, pulmonary edema, hypoxemia). Antibody formation. Risk of transmission of viral diseases. Have epinephrine inj available. Elderly. Pregnancy (Cat.C). Nursing mothers.
Interactions:
Concomitant nephrotoxic drugs: increased risk of renal toxicity. May affect response to live virus vaccines. May interfere with serological test interpretation.
Adverse Reactions:
Headache, pain, nausea, vomiting, fatigue, chills, joint swelling/effusion, pyrexia, urticaria, anemia, hyperthermia; hyperproteinemia, increased serum viscosity, hyponatremia; rare: aseptic meningitis syndrome (esp. high dose of 2g/kg), hemolysis, TRALI, thrombosis.
Generic Availability:
NO
How Supplied:
Single-use vial (50mL, 100mL, 200mL)—1