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PRINIVIL

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Generic Name for PRINIVIL

Lisinopril 2.5mg, 5mg+, 10mg, 20mg, 40mg; tabs; +scored.

Legal Classification:

Pharmacological Class for PRINIVIL

ACE inhibitor.

Manufacturer of PRINIVIL

Merck & Co., Inc.

Indications for PRINIVIL

Hypertension.

Adult dose for PRINIVIL

Initially and if not on diuretics: 10mg once daily. Usual range: 20–40mg once daily. If on diuretic: suspend diuretic for 2–3 days before starting; resume diuretic if BP not controlled by lisinopril alone. If diuretic cannot be discontinued: initially 5mg daily (supervise 1^st dose). CrCl 10–30mL/min: initially 5mg daily; CrCl <10mL/min: initially 2.5mg daily; max 40mg daily.

Children's dosing for PRINIVIL

<6yrs or CrCl <30mL/min/1.73m²: not recommended. ≥6yrs: initially 0.07mg/kg (max 5mg) once daily; usual max 0.61mg/kg (40mg) once daily.

Contraindications for PRINIVIL

History of ACEI-associated or other angioedema. Pregnancy (Cat.D in 2^ndand 3^rd trimesters).

Precautions for PRINIVIL

Renal impairment. Dialysis (esp. high-flux membrane). Salt/volume depletion. Hypertrophic cardiomyopathy. CHF. Ischemic heart disease. Cerebrovascular disease. Renal artery stenosis. Surgery. Monitor renal function, serum potassium in diabetics. Monitor WBCs in renal and collagen vascular disease patients. Discontinue immediately if angioedema or laryngeal edema occurs (have SC epinephrine available). Elderly. Pregnancy (Cat.C in 1^st trimester). Nursing mothers: not recommended.

Interactions for PRINIVIL

May cause hypotension or increased BUN with diuretics, hyperkalemia with K⁺ sparing diuretics or K⁺ supplements. May increase lithium levels; monitor frequently. Antagonized by, and increased risk of renal failure with, NSAIDs.

Adverse Reactions for PRINIVIL

Dizziness, headache, fatigue, diarrhea, upper respiratory symptoms, cough, nausea, hyperkalemia, orthostatic hypotension, renal impairment, angioedema; liver dysfunction, blood dyscrasias (rare).

How is PRINIVIL supplied?

Tabs 2.5mg—30, 100
Tabs 5mg—90, 100, 1000
Tabs 10mg, 20mg—30, 90, 100, 1000
Tabs 40mg—100

Related Disease:

Hypertension

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