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PRILOSEC

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Generic Name for PRILOSEC

Omeprazole 10mg, 20mg, 40mg; caps containing e-c delayed release granules.

Legal Classification:

Rx

Pharmacological Class for PRILOSEC

Proton pump inhibitor.

Manufacturer of PRILOSEC

AstraZeneca Pharmaceuticals

Indications for PRILOSEC

Triple therapy (w. amoxicillin + clarithromycin) or dual therapy (w. amoxicillin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment of active benign gastric ulcer, active duodenal ulcer, erosive esophagitis (EE), symptomatic GERD. Maintenance of healing of EE. Pathological hypersecretory conditions.

Adult dose for PRILOSEC

Take before eating. Swallow whole, or may mix contents of caps in applesauce and take immediately; do not crush or chew granules; follow with water. Triple therapy: omeprazole 20mg + clarithromycin 500mg + amoxicillin 1g, all every 12 hrs for 10 days; then (if ulcer was present at start): omeprazole 20mg once daily in the AM on days 11–28. Dual therapy (clarithromycin resistance more likely to develop than with triple therapy): omeprazole 40mg once daily in the AM + clarithromycin 500mg three times daily on days 1–14; then (if ulcer was present at start) omeprazole 20mg once daily in the AM on days 15–28. Active duodenal ulcer: 20mg once daily for 4 wks; may continue 4 more wks. Gastric ulcer: 40mg once daily for 4–8 weeks. GERD (no esophageal lesions): 20mg once daily for up to 4 weeks. EE with GERD symptoms: 20mg once daily for 4–8 wks; may give up to 4 more wks (if relapse of erosive esophagitis or GERD symptoms occurs may give additional 4–8 wk course). Maintenance of healing of EE: 20mg once daily. Hypersecretory conditions: initially 60mg once daily, then adjust; doses up to 120mg 3 times daily have been used; give doses >80mg/day in divided doses. Hepatic impairment or Asian: consider reducing dose (esp. for maintenance of healing of EE).

Children's dosing for PRILOSEC

Take before eating. Swallow whole, or may mix contents of caps in applesauce and take immediately; do not crush or chew granules; follow with water. <1yr: not recommended. 1–16yrs: GERD, EE: 5<10kg: 5mg daily. 10<20kg: 10mg daily; ≥20kg: 20mg daily.

Warnings/Precautions for PRILOSEC

Gastric malignancy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions for PRILOSEC

Concomitant atazanavir, nelfinavir: not recommended. Potentiates saquinavir, cilostazol; consider dose reduction of these drugs. May potentiate diazepam, phenytoin, warfarin, tacrolimus. Potentiated by voriconazole; may need to adjust omeprazole dose in Zollinger-Ellison syndrome. May alter absorption of pH-dependent drugs (eg, ketoconazole, digoxin, iron salts, ampicillin). Monitor drugs metabolized by CYP450 (eg, cyclosporine, disulfiram, benzodiazepines). May give antacids concomitantly.

Adverse Reactions for PRILOSEC

Headache, abdominal pain, GI upset, flatulence. Children: also, respiratory system events, fever.

Notes for PRILOSEC

See Amoxil entry for more information on amoxicillin. See Biaxin entry for more information on clarithromycin.

How is PRILOSEC supplied?

Caps 10mg—30; 20mg—30, 1000; 40mg—30, 100

Related Disease:

Duodenal ulcers {DU}
Erosive esophagitis
GERD {GERD}
Ulcers, duodenal
Ulcers, gastric

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