PREVACID
Generic Name for PREVACID
Lansoprazole 15mg, 30mg; e-c delayed-release granules in caps.
Legal Classification:
Rx
Pharmacological Class for PREVACID
Proton pump inhibitor.
Manufacturer of PREVACID
Takeda Pharmaceuticals America, Inc.
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Indications for PREVACID
Triple therapy (w. amoxicillin + clarithromycin) or dual therapy (w. amoxicillin; use only if allergic, intolerant, or resistant to clarithromycin) for H. pylori eradication in duodenal ulcer disease. Short-term treatment of active duodenal ulcer, active benign gastric ulcer, erosive esophagitis (EE), symptomatic GERD, and NSAID-associated gastric ulcers when NSAID use is continued. To reduce risk of NSAID-associated gastric ulcer in patients with history of gastric ulcer who need an NSAID. Maintenance of healing of duodenal ulcer, EE. Long-term treatment of pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome).
Adult dose for PREVACID
Take before eating. Do not crush or chew granules. Caps: swallow whole, or sprinkle granules and mix contents with food or juice (see literature) and take immediately. May open caps and mix granules in 40mL apple juice and give via NG tube; flush tube with more juice. SoluTabs: dissolve on tongue; swallow with or without water. May give via oral syringe or NG tube (see literature). Susp: mix in 30mL water and drink immediately; do not use NG tube. ≥18yrs: Triple therapy: lansoprazole 30mg + amoxicillin 1g + clarithromycin 500mg, all every 12 hours for 10 or 14 days. Dual therapy: lansoprazole 30mg + amoxicillin 1g, both every 8 hours for 14 days. Duodenal ulcer: 15mg once daily for 4 weeks. Gastric ulcer treatment: 30mg once daily for up to 8 weeks. EE treatment: 30mg once daily for up to 8 weeks; may repeat for 8 more weeks. If relapse occurs, may repeat 8-week course. GERD: 15mg once daily for up to 8 weeks. Maintenance of healing of duodenal ulcer or EE: 15mg once daily. Healing of NSAID-associated gastric ulcer: 30mg once daily for 8 weeks; NSAID ulcer risk reduction: 15mg once daily for up to 12 weeks. Hypersecretory conditions: Initially 60mg once daily, adjust as needed; give daily doses >120mg in divided doses.
Children's dosing for PREVACID
Take before eating. Do not crush or chew granules. Caps: swallow whole, or sprinkle granules and mix contents with food or juice (see literature) and take immediately. May open caps and mix granules in 40mL apple juice and give via NG tube; flush tube with more juice. SoluTabs: dissolve on tongue; swallow with or without water. May give via oral syringe or NG tube (see literature). Susp: mix in 30mL water and drink immediately; do not use NG tube. GERD or EE: ≤1 year: not recommended. 1–11 years: ≤30 kg: 15 mg once daily; >30 kg: 30 mg once daily. For both: give for up to 12 weeks; doses up to 30 mg twice daily have been used.
Also:
Warnings/Precautions for PREVACID
Severe hepatic impairment (consider dose reduction). Pregnancy (Cat.B). Nursing mothers: not recommended.
Interactions for PREVACID
May alter absorption of pH-dependent drugs (eg, ketoconazole, digoxin, iron, ampicillin). May antagonize atazanavir. Monitor theophylline, warfarin. Give at least 30 minutes before sucralfate. May give antacids concomitantly.
Adverse Reactions for PREVACID
Diarrhea, abdominal pain, nausea, constipation, headache.
Notes for PREVACID
See Amoxil entry for more information on amoxicillin. See Biaxin entry for more information on clarithromycin.
How is PREVACID supplied?
Caps 15mg—30, 1000
30mg—100, 1000
SoluTabs—30
Susp—30 packets/box
Related Disease:
Duodenal ulcers {DU}
Erosive esophagitis
GERD {GERD}
Hypersecretory conditions~Zollinger-Ellison syndrome
Ulcers, duodenal
Ulcers, gastric