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PONSTEL
Dysmenorrhea
Nonnarcotic analgesics
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Drug Name:

PONSTEL Rx

Generic Name and Formulations:
Mefenamic acid 250mg; caps.

Company:
Shionogi, Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for PONSTEL:

Dysmenorrhea.

Adult Dose for PONSTEL:

Take with food. ≥14yrs: 500mg once, then 250mg every 6 hrs; usually for up to 2–3 days.

Children's Dose for PONSTEL:

<14yrs: not recommended.

Pharmacological Class:

NSAID (fenamate).

Contraindications:

Aspirin allergy. GI ulceration or inflammation. Renal dysfunction. Late pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Active or history of hepatic dysfunction. Bleeding disorders. Fluid retention. Heart failure. Hypertension. Asthma. Monitor for GI ulcer/bleed (risk is increased if patient is otherwise at high-risk, extended drug treatment, high doses, smokers, alcoholics, history of GI bleed or ulcer); blood, renal, hepatic, and ocular function in chronic use. Dehydrated. Debilitated. Elderly (>65yrs). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid aspirin. Increased risk of GI bleed with anticoagulants, aspirin, corticosteroids. May potentiate methotrexate, oral anticoagulants, lithium; monitor. May be potentiated by magnesium-containing antacids. May antagonize antihypertensives, diuretics. May antagonize or increase risk of renal failure with concomitant ACE inhibitors or diuretics. Caution with inhibitors of CYP2C9.

Adverse Reactions:

GI disturbances (e.g., abdominal pain, constipation, diarrhea, dyspepsia, nausea, flatulence, GI ulceration or bleeding), anemia, dizziness, edema, renal or hepatic dysfunction, headache, pruritus, rash (discontinue if occurs), tinnitus, drowsiness, photosensitivity, CNS effects, alopecia, blurred vision. See literature re: risk of cardiovascular events.

How Supplied:

Caps—100

Indications for PONSTEL:

Mild to moderate pain.

Adult Dose for PONSTEL:

Take with food. ≥14yrs: 500mg once, then 250mg every 6 hrs; usually for up to 7 days.

Children's Dose for PONSTEL:

<14yrs: not recommended.

Pharmacological Class:

NSAID (fenamate).

Contraindications:

Aspirin allergy. GI ulceration or inflammation. Renal dysfunction. Late pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Active or history of hepatic dysfunction. Bleeding disorders. Fluid retention. Heart failure. Hypertension. Asthma. Monitor for GI ulcer/bleed (risk is increased if patient is otherwise at high-risk, extended drug treatment, high doses, smokers, alcoholics, history of GI bleed or ulcer); blood, renal, hepatic, and ocular function in chronic use. Dehydrated. Debilitated. Elderly (>65yrs). Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid aspirin. Increased risk of GI bleed with anticoagulants, aspirin, corticosteroids. May potentiate methotrexate, oral anticoagulants, lithium; monitor. May be potentiated by magnesium-containing antacids. May antagonize antihypertensives, diuretics. May antagonize or increase risk of renal failure with concomitant ACE inhibitors or diuretics. Caution with inhibitors of CYP2C9.

Adverse Reactions:

GI disturbances (e.g., abdominal pain, constipation, diarrhea, dyspepsia, nausea, flatulence, GI ulceration or bleeding), anemia, dizziness, edema, renal or hepatic dysfunction, headache, pruritus, rash (discontinue if occurs), tinnitus, drowsiness, photosensitivity, CNS effects, alopecia, blurred vision. See literature re: risk of cardiovascular events.

How Supplied:

Caps—100

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