Poisoning & Drug Dependence

FDA Cracks Down on Companies Selling Street Drug Alternatives

By December 12, 2017

The warning letter explains how the claims made in the promotional materials for Legal Lean Syrup and Coco Loko demonstrate that the products are intended to be used as alternatives to illicit street drugs and that the products, as labeled and marketed, may pose safety concerns.

New Treatment Option for Opioid Use Disorder Gets Approval

By December 01, 2017

Sublocade should be used as part of a complete treatment program that includes counseling and psychosocial support.

Most Multi-Med Patients Have Not Discussed Possible Drug Interactions

November 30, 2017

In terms of who is responsible for talking to patients about possible drug interactions, 11, 26, and 63% felt that the pharmacist, doctor, and both doctor and pharmacist are responsible, respectively.

Performance-Enhancing Substances Sold Online May Contain Unapproved Ingredients

November 30, 2017

The researchers found that 23 of the 44 products marketed and sold as selective androgen receptor modulators contained 1 or more selective androgen receptor modulator.

Naloxone Effectiveness Compared by Route of Administration

November 28, 2017

Higher-concentration intranasal naloxone (2mg/mL) seems to have efficacy similar to that of intramuscular naloxone for reversal of opioid overdose, with no difference in adverse events.

FDA Grants Priority Review to Lofexidine for Opioid Withdrawal Management

By November 21, 2017

Lofexidine, an oral tablet, is a selective alpha 2-adrenergic receptor agonist that reduces the release of norepinephrine.

Nonmedical Rx Drug Use and Dating Violence: What's the Link?

November 20, 2017

Nonmedical use of prescription drugs linked to dating violence for male, female high school students

Clinical Characteristics of Endogenous Endophthalmitis Examined in Injection Drug Users

November 20, 2017

Injection drug users have fewer comorbidities and more improvement in visual acuity after intervention

Treatments Compared for Prevention of Opioid Relapse

November 20, 2017

Difficulty initiating XR-NTX accounts for difference in relapse rates in intent-to-treat population

Device to Help Reduce Symptoms of Opioid Withdrawal Gets FDA Approval

By November 16, 2017

The FDA approval is supported by a single-arm clinical study of 73 patients undergoing opioid physical withdrawal.

Methamphetamine Heart Failure May Present New Phenotype

November 15, 2017

"Clinicians are seeing more heart failure with meth use, suggesting heart failure due to methamphetamine use could be a new epidemic," said lead author, Marin Nishimura, MD, in a statement.

Concerns About Kratom Prompt Statement from FDA Commissioner

By November 14, 2017

Kratom is plant that grows naturally in Thailand, Malaysia, Indonesia and Papua New Guinea. It has gained popularity in the U.S., with some marketers touting it as a "safe" treatment with broad healing properties.

DEA: All Illicit Fentanyl Analogues Will Be Scheduled

By November 09, 2017

In the current situation prosecutors need to overcome 'evidentiary hurdles' in gaining convictions of traffickers for illicit fentanyls coming into the country through the mail, shipping systems or imported across the southwest border.

ASCO: Alcohol Initiative May Decrease Cancer Burden

November 08, 2017

The statement promotes public education related to the risks of alcohol abuse and certain types of cancer.

Cannabidiol Products Sold Online Often Have Inaccurate Labeling

November 08, 2017

The researchers found that the observed CBD concentration varied from 0.1 to 655.27 mg/mL (median, 9.45 mg/mL); the median labeled concentration was 15 mg/mL.

FDA Advisory Committees Reach Decision on Opioid Use Disorder Tx

By November 01, 2017

A Phase 3 study found that 300mg and 100mg doses of RBP-6000 had significantly greater abstinence rates when compared with placebo; 300mg/300mg: 41.3%; 300mg/100mg: 42.7%; placebo: 5.0%.

Illicit Fentanyl Major Driver of Opioid Overdose Deaths in U.S.

November 01, 2017

Data from 10 states participating in the CDC's Enhanced State Opioid Overdose Surveillance program was used to describe opioid overdose deaths from July through December 2016 that tested positive for fentanyl; fentanyl analogs; or U-47700, an illicit synthetic opioid.

CDC Report Examines Tobacco Use By Industry, Occupation

October 30, 2017

The researchers found that 22.1% of working adults currently used any form of tobacco; 15.4, 5.8, 3, and 3.6% used cigarettes, other combustible tobacco, smokeless tobacco, and electronic cigarettes, respectively

Opioid Epidemic Declared Public Health Emergency

By October 27, 2017

Unlike a national emergency, which is what Mr. Trump has referred to the epidemic has, a public health emergency does not involved the release of any federal funds.

Walgreens Takes Steps to Make Life-Saving Drug More Accessible

By October 26, 2017

Narcan Nasal Spray, an opioid antagonist, is indicated for the reversal of known or suspected opioid overdose, including respiratory and/or central nervous system (CNS) depression.

NY State Bans E-Cigarette Use Where Tobacco Smoking Is Prohibited

By October 24, 2017

Studies into the long-term health impact of e-cigarettes - which usually contain nicotine - are limited but of the studies that have been completed, there have been mixed results.

Opioid Dependence Prevention Txs Compared in Head-to-Head Study

By October 18, 2017

Results found that all primary endpoints for non-inferiority of extended-release naltrexone group were met; retention in treatment (P=0.04), group proportion of total number of opioid-negative urine drug tests (P<0.001), days of heroin use (P<0.001) and days of other illicit opioids use (P<0.001).

Alcohol May Contribute to Premature Mortality in Psoriasis Patients

By October 17, 2017

The researchers compared an cohort of patients with psoriasis (≥18 years of age) drawn from several databases to 20 patients without psoriasis who were matched by age, sex, and general practice (n=55,537 and 854,314 respectively).

CVVH + Hemoperfusion Effective in Severe Metformin-Associated Toxicity

October 17, 2017

Case report describes treatment of female patient who attempted suicide with metformin overdose

Changing Marijuana Laws May Mean More Screening, Counseling Needed

October 10, 2017

In the changing legal environment, pediatric physicians must review their approach to screening for marijuana use and discussing the associated health consequences

Breath Sensor, App Combo Provide Novel Approach to Smoking Cessation

By October 06, 2017

The Carbon Monoxide Breath Sensor System (COBSS) informs the user how breath carbon monoxide levels are affected by their smoking behavior.

Electrolyte Disturbances Common Among Patients with Alcohol-Use Disorder

October 06, 2017

Telltale signs of chronic alcohol use are large drops in plasma phosphate, magnesium, potassium, calcium

E-Cigarette Switch Strategy Linked to Fewer Premature Deaths

October 04, 2017

Under pessimistic model, 1.6 million premature deaths prevented, 20.8 million fewer life-years lost

CVS Plans to Limit Opioid Rxs to 7-Day Supply for Certain Patients

By September 22, 2017

At the pharmacy level, a greater emphasis will be placed on counseling to help patients understand the risks associated with opioid use based on the new Centers for Disease Control and Prevention (CDC) guidelines.

'Death Wish' Coffee Recalled Due to Deadly Toxin Risk

By September 21, 2017

The company reached the decision with an outside Process Authority, who determined that their manufacturing process had the potential to create the deadly toxin botulin.