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Topical pain relief
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Generic Name and Formulations:

Lidocaine 7%, tetracaine 7%; emulsion cream.

Select therapeutic use:

Indications for PLIAGLIS:

Local analgesia for superficial dermatological procedures (eg, dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, laser-assisted tattoo removal).


Do not exceed recommended dose or duration. Apply to intact skin prior to procedure; spread evenly and thinly across treatment area using a metal spatula or tongue depressor. Dermal filler inj or facial laser ablation: apply for 20–30 mins. Laser-assisted tattoo removal: apply for 60 mins. Amount (length) to apply: see full labeling.


Not established.


PABA hypersensitivity.


Avoid overexposure. History of congenital or idiopathic methemoglobinemia: not recommended. G6PD deficiency. Severe hepatic impairment. Pseudocholinesterase deficiency. Avoid contact with eyes, mucous membranes, or areas with a compromised skin barrier (eg, broken or inflamed). Risks of secondary exposure to children and pets; may be toxic. Acutely ill. Debilitated. Elderly. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:

Topical anesthetic (amide-type + ester-type).


Toxicity may be potentiated by Class I antiarrhythmics (eg, tocainide, mexiletine); caution. Additive effects with other local anesthetics; consider the amount absorbed from all formulations. Increased risk of methemoglobinemia with concomitant methemoglobin-inducing agents (eg, sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, p- aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine).

Adverse Reactions:

Localized reactions (eg, erythema, skin discoloration, edema), allergic reactions (eg, urticaria, angioedema, bronchospasm, shock).


Lidocaine: hepatic.


Lidocaine: renal.

Generic Availability:


How Supplied: