PLAVIX
Generic Name for PLAVIX
Clopidogrel (as bisulfate) 75mg, 300mg; tabs.
Legal Classification:
Rx
Pharmacological Class for PLAVIX
Platelet aggregation inhibitor.
Manufacturer of PLAVIX
BMS/Sanofi Pharmaceuticals Partnership
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Indications for PLAVIX
Reduction of atherosclerotic events in: recent MI or stroke, peripheral arterial disease; non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI) or ST-segment elevation acute MI; see literature.
Adult dose for PLAVIX
75mg once daily. Non-ST-segment acute coronary syndrome (give with aspirin 75–325mg once daily): give one 300mg loading dose first. ST-segment elevation acute MI (give with aspirin, with or without thrombolytics): may start with or without a loading dose.
Children's dosing for PLAVIX
Not recommended.
Contraindications for PLAVIX
Active pathologic bleeding (eg, peptic ulcer, intracranial hemorrhage).
Precautions for PLAVIX
Risk of bleeding (eg, surgery, ulcers, trauma, concomitant NSAIDs). Severe hepatic or renal disease. Consider discontinuing 5 days before elective surgery. Pregnancy (Cat.B). Nursing mothers: not recommended.
Interactions for PLAVIX
Avoid concomitant CYP2C19 inhibitors (eg, omeprazole, esomeprazole, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, fluoxetine, fluvoxamine, ticlopidine). Caution with drugs that increase risk of bleeding (eg, NSAIDs, warfarin), and with drugs metabolized by CYP2C9 (eg, phenytoin, tolbutamide, tamoxifen, warfarin, torsemide, fluvastatin, many NSAIDs).
Adverse Reactions for PLAVIX
Bleeding, GI upset/ulcers, bruising, rash, pruritus, dizziness, headache; rare: thrombotic thrombocytopenic purpura, neutropenia, agranulocytosis.
How is PLAVIX supplied?
Tabs 75mg—30, 90, 500
300mg—30, 100
Related Disease:
Acute coronary syndrome
Coagulation disorders