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Periodontal disease
Only 4 drugs may be compared at once

Generic Name and Formulations:

Doxycycline hyclate 20mg; tabs.

Select therapeutic use:

Indications for PERIOSTAT:

As an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.


Take on an empty stomach with adequate amount of fluid. 20mg twice daily (in AM and PM). May give up to 9 months.


Not recommended.


Nursing mothers. Infants. Children.


History of or active oral candidiasis. Monitor blood, renal, and hepatic function in long-term use. Avoid sun and UV light. Pregnancy (Cat.D): not recommended.


Avoid concomitant penicillins, methoxyflurane. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Carbamazepine, barbiturates, phenytoin may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Photosensitivity, GI upset, rash, blood dyscrasias; rare: hepatotoxicity.

How Supplied:

Tabs—60, 100