Pediatrics

Prevalence of Rx Med Use Among Children, Adolescents Examined

September 20, 2018

8.2% of concurrent users of prescription meds at risk for potentially major drug-drug interactions

Infant PPI Use and Lung Infection Risk: Is There a Link?

By September 20, 2018

The data showed matched odds ratio for current vs past use of PPIs to be 0.88 (95% CI, 0.36 to 2.16) when comparing cases and their controls for community-acquired pneumonia. With regard to lower respiratory tract infections, the matched odds ratio between cases and their controls was 1.13 (95% CI, 0.87 to 1.48).

FDA Ad Campaign Hopes to Halt E-Cigarette Use Among Teens

September 19, 2018

In addition, the FDA wants to be sure young people are aware that e-cigarettes can contain dangerous chemicals such as acrolein, a chemical that can cause irreversible lung damage; formaldehyde, a cancer-causing chemical; and toxic metal particles like chromium, lead and nickel, which can be inhaled into the lungs.

Dupilumab Beneficial in Adolescent Patients With Moderate-to-Severe Atopic Dermatitis

By September 18, 2018

The Phase 3 trial enrolled 251 patients aged 12-17 years old with moderate-to-severe atopic dermatitis, whose disease was not adequately controlled by prescription topical medications or for whom topical treatment was medically inadvisable.

Factors Predictive of Escalated Care in Infant Bronchiolitis ID'd

September 18, 2018

Multivariable predictors included oxygen saturation <90%, nasal flaring and/or grunting, apnea, retractions, age ≤2 months, dehydration, and poor feeding (odds ratios, 8.9, 3.8, 3.0, 3.0, 2.1, 2.1, and 1.9, respectively).

Many Foster Kids Inappropriately Prescribed Psychiatric Drugs

September 18, 2018

A report from the Department of Health and Human Services (HHS) found that 1 in 3 foster children sampled in 5 states received the drugs without treatment plans or follow-up.

FDA Fast-Tracks Miransertib for PIK3CA-Related Overgrowth Spectrum

By September 14, 2018

Miransertib is an orally available, selective, pan-AKT (protein kinase B) inhibitor that potently inhibits AKT1, 2 and 3 isoforms.

Actemra SC Approved to Treat Active Systemic Juvenile Idiopathic Arthritis

By September 13, 2018

The approval of the SC formulation for this patient population was based on data from the JIGSAW-118 study, a 52-week, open-label, multicenter, pharmacokinetic (PK)/pharmacodynamic (PD) study.

FDA Gets Tough on Juul, Other Electronic Cigarette Makers

September 13, 2018

All of these brands - JUUL, Vuse, MarkTen, blu e-cigs, and Logic - made up the majority of products sold illegally to minors, the agency said.

NICU Antibiotic Use Rates Declined From 2013 to 2016

September 10, 2018

There was no correlation between the 2016 AUR and either proven infection or necrotizing enterocolitis. However, there was an association between the 2016 regional NICU AUR and surgical volume, mortality rate, and average length of stay

CDC: New Guideline for Pediatric Mild TBI Diagnosis, Management

September 10, 2018

Gradually increasing academic pursuits requires careful planning among the medical, school, and family units to enable prompt return and avoidance of prolonging school absence.

American Academy of Pediatrics Updates Car Seat Guidance

September 10, 2018

The updated recommendations include the following: rear-facing car safety seats as long as possible; forward-facing car safety seats from the time they outgrow rear-facing seats.

Adding Fish Oil in Pregnancy May Lead to Higher Child BMI

September 07, 2018

Supplementation linked to higher BMI z score at age 6 years but no higher proportion of obese children

Veta Smart Case, App for Epinephrine Auto-Injectors Now Available

By September 06, 2018

The Smart Case includes electronics and sensors to monitor the proximity, temperature, presence and removal, and expiration of auto-injectors.

Walgreens to Offer Auvi-Q Nationwide in an Effort to Address Epinephrine Supply Issues

By September 06, 2018

This effort is in response to epinephrine auto-injector supply issues reported by manufacturers to the Food and Drug Administration (FDA).

130 Now Sickened by <i>Salmonella</i>-Tainted Honey Smacks Cereal

September 06, 2018

The cereal under recall includes Honey Smacks 15.3 oz. size with the UPC code of 3800039103 and a Best if Used by Date of JUN 14, 2018, through JUN 14, 2019.

Despite guidelines, use of CT for head trauma in children remains unchanged

September 05, 2018

The Pediatric Emergency Care Applied Research Network (PECARN) published clinical prediction rules in 2009 to identify children with head trauma for whom computed tomography (CT) neuroimaging can be avoided.

Sympazan Oral Film Granted Tentative Approval for Lennox-Gastaut Syndrome

By September 04, 2018

Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).

FDA Rejects ADHD Drug NDA Citing Need for More Data

By August 31, 2018

The FDA stated that the dasotraline NDA cannot be approved in its current form and is requiring additional data to further assess the efficacy and tolerability of the drug.

Novel Epinephrine Nasal Spray for Anaphylaxis Gets Fast Tracked by FDA

By August 31, 2018

The bioavailability of the novel epinephrine nasal spray also proved similar to that of intramuscular injection with EpiPen 0.3mg injection.

Many ED Visits for Antibiotic Adverse Drug Events in Children

August 31, 2018

Based on 6542 surveillance cases, the researchers estimated that 69,464 emergency department visits were made annually for antibiotic ADEs among children aged 19 years or younger from 2011 to 2015.

Drinking Water Turned Off in All Detroit's Public Schools

August 31, 2018

Recent tests revealed "higher than acceptable levels... (of) copper and/or lead" in at least 1 water source - such as a fountain or sink - at 16 of 24 schools, Vitti said.

FDA to Review Sprycel as Add-On to Chemotherapy in Pediatric Ph+ ALL

By August 30, 2018

The sBLA contains data from the Phase 2 CA180-372 trial evaluating Sprycel as an add-on to chemotherapy regimen modeled on a Berlin-Frankfurt-Munster high-risk backbone in pediatric patients with newly diagnosed Ph+ ALL.

Bacterial Conjunctivitis Treatments

August 30, 2018

Bacterial conjunctivitis treatment chart for topical medications.

Jivi With Step-Wise Dosing Approved for Management of Hemophilia A

By August 30, 2018

The approval was supported by data from the phase 2/3 international, open-label PROTECT VIII trial (N=126) that evaluated previously treated patients aged ≥12 years with severe hemophilia A.

FDA: Hundreds of Human, Pet Homeopathy Products Recalled

August 29, 2018

Those at highest risk from the recalled products include infants, children, pregnant women, and people with weakened immune systems, the FDA said.

Children's Advil Suspension Recalled Due to Unmatched Dosage Cup

By August 28, 2018

The recalled product has Lot #R51129 (NDC 0573-0207-30) and was shipped to wholesalers, distributors, and retailers from May through June 2018.

Marijuana Detected in Breast Milk Up to 6 Days After Maternal Use

By August 28, 2018

The legalization of marijuana in several states has led to increased use of the drug for both medicinal and recreational purposes.

FDA Bans E-Cig Liquid Products That Look Like Snacks, Candies

August 24, 2018

Labels and ads for the nicotine-containing e-liquids were false or misleading, and potentially dangerous

CDC: Updated Influenza Vaccination Recommendations for 2018-2019

By August 23, 2018

In general, routine annual vaccination is recommended for all patients ≥6 months of age who have no contraindications.