Pediatrics

Otic Preparations

June 21, 2018

Otic drug preparations treatment chart for infections, pain, or wax build-up in the ear.

Acute Otitis Media Treatments

June 21, 2018

Acute otitis media treatment chart including select antibiotics and recommended doses.

Pediatric Chronic Rhinosinusitis: Treatment Options to Consider

By June 20, 2018

Because determining an appropriate treatment plan for a patient depends on the subtype of the disease, it is imperative for providers to know and understand the underlying mechanisms of CRS as well as the components included in a medical evaluation of a patient.

Pharmacologic Tx Should Be Used Sparingly for Reflux in Preemies

June 19, 2018

There is a lack of evidence for efficacy of pharmacologic agents and emerging evidence of significant harm; consequently, these agents should be used sparingly, if at all.

CDC: Many High School Students Engage in Health-Risk Behaviors

June 19, 2018

Many high school students were engaged in behaviors associated with chronic disease; 8.8% had smoked cigarettes and 13.2% had used an electronic vapor product on at least 1 day during the past 30 days.

FDA Lifts Clinical Hold on Trial for Duchenne Muscular Dystrophy Treatment

By June 18, 2018

SGT-001 is a novel adeno-associated viral (AAV) vector mediated gene transfer that could potentially address the underlying genetic cause of DMD, mutations in the dystrophin gene.

Resistant <i>A. Baumannii</i> Rose in Children From 1999 to 2012

June 18, 2018

The researchers found that the crude proportion of cephalosporin-resistant (CephR) A. baumannii increased from 13.2% in 1999 to 23.4% in 2012, with a peak of 32.5% in 2008. Similarly, the proportion of carbapenem(CR)-resistant A. baumannii increased from 0.6% in 1999 to 6.1% in 2012, peaking at 12.7% in 2008.

Good Sleep Tied to Better Cardiometabolic Health in Youths

June 15, 2018

"These results support the need to assess the role of sleep quantity and quality interventions as strategies for improving cardiovascular risk profiles of adolescents," the authors write.

Amblyopia, Strabismus May Slow Test Performance in Children

June 15, 2018

Compared with children in the control group, children with amblyopia had a slower mean time to completion (P=.001), as did children with non-amblyopic strabismus (P=.002).

A4250 Granted Rare Pediatric Disease Designation for Progressive Cholestasis

By June 13, 2018

The first patient has been enrolled in PEDFIC-1, a phase 3, single, randomized, double-blind, placebo-controlled trial designed to evaluate A4250 in 60 patients (aged 6 months-18 years) with PFIC subtype 1 or 2 who have elevated serum bile acid (sBA) levels and pruritus.

Most Infants and Toddlers Consume Added Sugar

June 12, 2018

There was a significant increase in consumption by age, from 0.9 to 5.5 and 7.1 teaspoons for infants aged 6 to 11 months, and toddlers aged 12 to 18 and 19 to 23 months, respectively.

Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion

By June 11, 2018

Noting that infants and children who ingest button batteries can experience esophageal damage leading to significant morbidity and death in as little as 2 hours, researchers from the Children's Hospital of Philadelphia and Nationwide Children's Hospital aimed to identify effective options for mitigating these effects by testing common weakly acidic household beverages, viscous liquids, and sucralfate (Carafate).

Isolated mild/moderate thrombocytopenia may not require intervention

June 11, 2018

In a review of children who presented to a specialist hematology clinic with isolated mild or moderate low platelet counts, though causes were variable, most required no interventions.

2011 to 2017 Saw Drop in Youth Use of Any Tobacco Products

June 11, 2018

The researchers found that from 2011 to 2017 there was a decrease in current use of any tobacco product among high school students, from 24.2 to 19.6%, and from 7.5 to 5.6% among middle school students.

Infant Omega-3 Supplementation Tied to Decreased Waist Size

June 08, 2018

The researchers found that infants who received n-3 LCPUFA had a smaller waist circumference at 5 years (coefficient, 1.1cm), which remained significant after adjusting for confounders (coefficient, 0.8cm).

Factors ID'd for Persistent Opioid Use After Pediatric Surgery

June 07, 2018

Researchers assessed factors associated with post-discharge persistent opioid use of up to 6 months in a group of 86 children and adolescents (median age, 12 years) who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

Microbiota in Breastfed Infants May Help Prevent Overweight

June 06, 2018

The researchers found that in covariate-adjusted models, infants who were exclusively formula-fed at 3 months had increased risk of overweight (adjusted odds ratio, 2.04; 95% confidence interval, 1.25 to 3.32).

CDC: Death Rate for American Youth Up in Recent Years

June 01, 2018

The researchers found that there was a 33% decrease in the total death rate for persons aged 10 to 19 years between 1999 and 2013 (from 44.4 to 29.6 per 100,000 population), followed by a 12% increase (to 33.1 per 100,000 population) between 2013 and 2016.

Fycompa Granted Priority Review for Pediatric Indications

By May 30, 2018

The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Most Premature Infants Receive Early Antibiotics

May 30, 2018

"The variability in exposure rates across centers, however, suggests that neonatal antimicrobial stewardship efforts are warranted to optimize antibiotic use for VLBW and ELBW infants," the authors write.

Oral Contraceptive Taytulla Recalled Due to Packaging Error

By May 29, 2018

A physician report indicates that 4 placebo (non-hormonal) capsules were placed in the first 4 days of therapy instead of active capsules.

Adolescent mothers in protective care more likely to have their children placed in care

May 29, 2018

Children born to adolescent mothers in the care of child protection services (CPS) were more likely to be taken into CPS care themselves when compared to other children in the first 2 years of life.

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

By May 24, 2018

This investigational lentiviral-based gene therapy is currently being studied in the Phase 2/3 Starbeam Study, a 2-year study assessing the safety and efficacy of Lenti-D in boys ≤17 years old with CALD.

AAP: Congress Urged to Act to Prevent Firearm Deaths

May 24, 2018

Following latest shooting, pediatricians join call for action to be taken to address firearm deaths, injury

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

By May 23, 2018

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

Increase in Pediatric ADHD Meds Exposures from 2000 to 2011

May 23, 2018

Intentional meds exposure most often reported among teens, accounting for half of teen exposure

AAP Recommends Shot Over Nasal Spray for 2018-2019 Flu Season

By May 22, 2018

The advisory comes early as physicians are currently placing vaccine orders.

Homeopathic Products for Teething, Nausea, Colic, Cough Recalled

By May 18, 2018

Recalled products include Teething Drops, Nausea Drops, Intestinal Colic Drops, Stomach Calm, Expectorant Cough Syrup, Silver-Zinc Throat Spray, and Argentum Elixir.

RA Treatment During Pregnancy: Is Infection Risk Greater in Offspring?

By May 18, 2018

Offspring were followed from birth until 12 months, first indication of serious infection, end of commercial insurance eligibility, death or end of study period, whichever came first.

Truvada Approved for HIV-1 Pre-Exposure Prophylaxis in At-Risk Adolescents

By May 17, 2018

The use of Truvada for PrEP in the adolescent population was based on a single-arm, open-label clinical study (ATN113) among 67 HIV-1 negative young men (aged 15 to 17 years) who have sex with men (YMSM).