Select therapeutic use:
Indications for PCE:
Susceptible infections including upper and lower respiratory, skin and soft tissue, genitourinary, Legionnaires' disease, pertussis, listeriosis.
Preferably take 2hrs before meals. Usually 333mg every 8hrs or 500mg every 12hrs. Genitourinary: two 333mg tabs every 8hrs or 500mg 4 times daily for 7 days. Legionnaires: 1–4g daily in divided doses. Max 4g daily; twice daily dosing max 1g/day.
Preferably give 2hrs before meals. Mild-to-moderate infections: 30–50mg/kg/day; may double dose in severe infections. Both in divided doses. Max 4g daily.
Concomitant cisapride, pimozide, ergotamine, dihydroergotamine.
Hepatic dysfunction. Proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); QT prolongation may occur, avoid. Myasthenia gravis. Elderly. Pregnancy (Cat.B). Nursing mothers.
See Contraindications. May potentiate or be potentiated by drugs metabolized by CYP3A (eg, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine). May potentiate or be potentiated by hexobarbital, phenytoin, valproate. May potentiate triazolam, midazolam, digoxin, theophylline, statins (rhabdomyolysis), sildenafil (reduce dose of sildenafil), colchicine (reduce starting dose of colchicine, max dose should be lowered; monitor). Hypotension, bradyarrhythmias, lactic acidosis with verapamil. Hypotension with calcium channel blockers metabolized by CYP3A4 (eg, verapamil, amlodipine, diltiazem). Increased anticoagulant effects with oral anticoagulants. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics. May interfere with fluorometric detection of urinary catecholamines.
GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation.
Tabs 333mg—60; 500mg—100