PAXIL
Generic Name for PAXIL
Paroxetine (as HCl) 10mg+, 20mg+, 30mg, 40mg; tabs; +scored.
Legal Classification:
Rx
Pharmacological Class for PAXIL
SSRI.
Manufacturer of PAXIL
GlaxoSmithKline Pharmaceuticals
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Indications for PAXIL
Panic disorder. Social anxiety disorder. Obsessive-compulsive disorder (OCD). Generalized anxiety disorder (GAD). Posttraumatic stress disorder (PTSD).
Adult dose for PAXIL
Give once daily, usually in the AM, adjust by 10mg/day at 1-week intervals. Panic disorder: initially 10mg/day; usual 40mg/day; max 60mg/day. Social anxiety disorder: 20mg/day; max 60mg/day. OCD: initially 20mg/day, usual 40mg/day; max 60mg/day. GAD or PTSD: 20mg/day; max 50mg/day. Elderly, debilitated, severe renal or hepatic impairment: initially 10mg/day; max 40mg/day.
Children's dosing for PAXIL
Not recommended.
Also:
Contraindications for PAXIL
Concomitant pimozide, thioridazine (may cause QTc prolongation). During or within 14 days of MAOIs (including linezolid).
Precautions for PAXIL
History of seizures (discontinue if occurs), mania/hypomania. Monitor for serotonin syndrome or neuroleptic malignant syndrome-like signs and symptoms; discontinue if occurs. Conditions that affect metabolism or hemodynamic response. Cardiac disease. ECT. Narrow angle glaucoma. Suicidal tendencies (monitor). Write ℞ for smallest practical amount. Avoid abrupt cessation; reduce dose gradually. Reevaluate periodically. Elderly. Labor & delivery. Pregnancy (Cat.D); avoid use. Nursing mothers.
Interactions for PAXIL
See Contraindications. Do not start MAOI until at least 2 weeks after discontinuing paroxetine. Concomitant SSRIs, SNRIs, tryptophan: not recommended. Avoid alcohol. Potentiation with other protein bound drugs. Caution with drugs that affect coagulation (eg, warfarin, NSAIDs). Potentiated by cimetidine. Antagonized by fosamprenavir/ritonavir. May affect, or be affected by, drugs metabolized by CYP2D6, including tricyclic antidepressants, fluoxetine, phenothiazines, risperidone, atomoxetine, tamoxifen, Class 1C antiarrhythmics, quinidine. Monitor digoxin, phenytoin, phenobarbital, theophylline, warfarin. Reduce procyclidine dose if anticholinergic effects occur. Caution with triptans, linezolid, lithium, tramadol, St. John's wort or dopamine antagonists; may cause serotonin syndrome (eg, agitation, tachycardia, incoordination, hyperreflexia). Hormonal contraceptives and PMDD treatment: see literature.
Adverse Reactions for PAXIL
GI upset, asthenia, sweating, decreased appetite, somnolence, dizziness, insomnia, nervousness, headache, decreased libido, tremor, akathisia, dry mouth, abnormal ejaculation, genital disorders, impotence, hyponatremia, abnormal bleeding, others; serious discontinuation symptoms (monitor); rare: neuroleptic malignant syndrome.
How is PAXIL supplied?
CR—30
Tabs 10mg, 30mg, 40mg—30
20mg—30, 90
Susp—250mL
Related Disease:
Anxiety
Obsessive-compulsive disorder
Panic disorder
Social anxiety disorder