PAXIL SUSPENSION
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PAXIL SUSPENSION to:
Generic Name for PAXIL SUSPENSION
Paroxetine (as HCl) 10mg/5mL; orange-flavored liq.
Legal Classification:
Rx
Pharmacological Class for PAXIL SUSPENSION
SSRI.
Manufacturer of PAXIL SUSPENSION
GlaxoSmithKline Pharmaceuticals
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Indications for PAXIL SUSPENSION
Depression.
Adult dose for PAXIL SUSPENSION
Give once daily, usually in the AM, adjust by 10mg/day at 1-week intervals. Initially 20mg/day; max 50mg/day. Elderly, debilitated, severe hepatic or renal impairment: initially 10mg/day; max 40mg/day.
Children's dosing for PAXIL SUSPENSION
Not recommended.
Also:
Contraindications for PAXIL SUSPENSION
Concomitant pimozide, thioridazine (may cause QTc prolongation). During or within 14 days of MAOIs (including linezolid).
Warnings/Precautions for PAXIL SUSPENSION
History of seizures (discontinue if occurs), mania/hypomania. Monitor for serotonin syndrome or neuroleptic malignant syndrome-like signs and symptoms; discontinue if occurs. Conditions that affect metabolism or hemodynamic response. Cardiac disease. ECT. Narrow angle glaucoma. Suicidal tendencies (monitor). Write ℞ for smallest practical amount. Avoid abrupt cessation; reduce dose gradually. Reevaluate periodically. Elderly. Labor & delivery. Pregnancy (Cat.D); avoid use. Nursing mothers.
Interactions for PAXIL SUSPENSION
See Contraindications. Do not start MAOI until at least 2 weeks after discontinuing paroxetine. Concomitant SSRIs, SNRIs, tryptophan: not recommended. Avoid alcohol. Potentiation with other protein bound drugs. Caution with drugs that affect coagulation (eg, warfarin, NSAIDs). Potentiated by cimetidine. Antagonized by fosamprenavir/ritonavir. May affect, or be affected by, drugs metabolized by CYP2D6, including tricyclic antidepressants, fluoxetine, phenothiazines, risperidone, atomoxetine, tamoxifen, Class 1C antiarrhythmics, quinidine. Monitor digoxin, phenytoin, phenobarbital, theophylline, warfarin. Reduce procyclidine dose if anticholinergic effects occur. Caution with triptans, linezolid, lithium, tramadol, St. John's wort or dopamine antagonists; may cause serotonin syndrome (eg, agitation, tachycardia, incoordination, hyperreflexia). Hormonal contraceptives and PMDD treatment: see literature.
Adverse Reactions for PAXIL SUSPENSION
GI upset, asthenia, sweating, decreased appetite, somnolence, dizziness, insomnia, nervousness, headache, decreased libido, tremor, akathisia, dry mouth, abnormal ejaculation, genital disorders, impotence, hyponatremia, abnormal bleeding, others; serious discontinuation symptoms (monitor); rare: neuroleptic malignant syndrome.
How is PAXIL SUSPENSION supplied?
CR—30
Tabs 10mg, 30mg, 40mg—30
20mg—30, 90
Susp—250mL
Related Disease:
Depression
Premenstrual dysphoric disorder