PAXIL CR

Generic Name for PAXIL CR Paroxetine (as HCl) 12.5mg, 25mg, 37.5mg; controlled-release e-c tabs. Legal Classification: Rx Pharmacological Class for PAXIL CR SSRI. Manufacturer of PAXIL CR GlaxoSmithKline Pharmaceuticals

Indications for PAXIL CR

Panic disorder. Social anxiety disorder.

Adult dose for PAXIL CR

Swallow whole. Give once daily, usually in the AM, adjust by 12.5mg/day at 1-week intervals. Panic disorder: initially 12.5mg/day; max 75mg/day. Social anxiety disorder: initially 12.5mg/day; max 37.5mg/day. Elderly, debilitated, severe hepatic or renal impairment: initially 12.5mg once daily; max 50mg/day.

Children's dosing for PAXIL CR

Not recommended.

Also:

Contraindications for PAXIL CR

Concomitant pimozide, thioridazine (may cause QTc prolongation). During or within 14 days of MAOIs (including linezolid).

Precautions for PAXIL CR

History of seizures (discontinue if occurs), mania/hypomania. Monitor for serotonin syndrome or neuroleptic malignant syndrome-like signs and symptoms; discontinue if occurs. Conditions that affect metabolism or hemodynamic response. Cardiac disease. ECT. Narrow angle glaucoma. Suicidal tendencies (monitor). Write ℞ for smallest practical amount. Avoid abrupt cessation; reduce dose gradually. Reevaluate periodically. Elderly. Labor & delivery. Pregnancy (Cat.D); avoid use. Nursing mothers.

Interactions for PAXIL CR

See Contraindications. Do not start MAOI until at least 2 weeks after discontinuing paroxetine. Concomitant SSRIs, SNRIs, tryptophan: not recommended. Avoid alcohol. Potentiation with other protein bound drugs. Caution with drugs that affect coagulation (eg, warfarin, NSAIDs). Potentiated by cimetidine. Antagonized by fosamprenavir/ritonavir. May affect, or be affected by, drugs metabolized by CYP2D6, including tricyclic antidepressants, fluoxetine, phenothiazines, risperidone, atomoxetine, tamoxifen, Class 1C antiarrhythmics, quinidine. Monitor digoxin, phenytoin, phenobarbital, theophylline, warfarin. Reduce procyclidine dose if anticholinergic effects occur. Caution with triptans, linezolid, lithium, tramadol, St. John's wort or dopamine antagonists; may cause serotonin syndrome (eg, agitation, tachycardia, incoordination, hyperreflexia). Hormonal contraceptives and PMDD treatment: see literature.

Adverse Reactions for PAXIL CR

GI upset, asthenia, sweating, decreased appetite, somnolence, dizziness, insomnia, nervousness, headache, decreased libido, tremor, akathisia, dry mouth, abnormal ejaculation, genital disorders, impotence, hyponatremia, abnormal bleeding, others; serious discontinuation symptoms (monitor); rare: neuroleptic malignant syndrome.

How is PAXIL CR supplied?

CR—30
Tabs 10mg, 30mg, 40mg—30
20mg—30, 90
Susp—250mL