Accidental dosing with Cyclobenzaprine HCl may potentially lead to life-threatening serotonin syndrome when the drug is taken in combination with selective serotonin reuptake inhibitors.
"We found direct relationships between the frequency of word puzzle use and the speed and accuracy of performance on nine cognitive tasks assessing a range of aspects of function including attention, reasoning, and memory," researcher Keith Wesnes, PhD.
Magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) with a 3-T magnetic resonance imager revealed that the Parkinson's patients had significant alterations in optic radiation connectivity distribution.
Patients taking Xadago also experienced less "off" time and better scores on a measure of motor function performed during "on" time vs. prior to treatment.
The researchers found that, compared with controls, patients with Parkinson's disease had a 3.8-fold increased likelihood of having preexisting melanoma, while patients with melanoma had a 4.2-fold increased risk of developing Parkinson's disease.
Researchers reviewed a total of 2,314 articles for zolpidem used to treat neurologic disorders across various databases.
Nelotanserin is a novel once-daily oral 5HT2A inverse agonist. The 5HT2A receptor has been associated with neuropsychiatric effects, including visual hallucinations.
The study's primary endpoint was meaningful improvement in motor function as defined by the Unified Parkinson's Disease Rating Scale—Part III.
The average total motor complication score was also reduced from 8.8 at baseline to 4.2 after 12 months of add-on ultra-micronized palmitoylethanolamide.
While the GHR tests may provide genetic risk information, they cannot determine a person's overall risk for developing a disease, as other factors beyond genetics (ie, environment, lifestyle) may also influence risk.
Researchers compared health-related quality of life and mobility between self-reported regular exercisers and patients who did not exercise.
Fixed-dose studies, showed no added therapeutic benefit in patients with advanced stage Parkinson's disease taking daily doses >8mg/day or among those with early stage Parkinson's taking daily doses >12mg/day.
Acorda Therapeutics announced statistically significant results from the Phase 3 study of CVT-301, an investigational inhaled formulation of levodopa, for the treatment of OFF periods in patients with Parkinson's disease (PD) on an oral carbidopa/levodopa regimen.
Measuring blood neurofilament light chain (NfL) levels may help distinguish Parkinson's disease (PD) from atypical parkinsonian disorders (APD), according to a study published onlinein Neurology.
The FDA has accepted for review the New Drug Application (NDA) for ADS-5102 (amantadine extended-release capsules; Adamas) for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.
Anticholinergic medications are frequently prescribed to older adults, but their negative impact should be considered, according to a review published online December 23 in the Journal of Pharmacy Practice and Research.
Adamas announced it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for ADS-5102 (amantadine hydrochloride) extended-release capsules, to potentially treat levodopa-induced dyskinesia (LID) in patients with Parkinson's disease (PD).
An inhaled version of the Parkinson's drug levodopa can help when patients experience symptoms between doses of the pill form of the medication, according to a study published in the October 12 issue of Science Translational Medicine.
The concept of autophagy emerged around the 1960s but its mechanisms had not been fully elucidated until the 1990s when Ohsumi began experimenting with baker's yeast.
Virtus announced a voluntary recall of 7 lots of Hyoscyamine Sulfate 0.125mg due to both superpotent and subpotent test results.
The Food and Drug Administration (FDA) has approved labeling updates regarding dosage and warnings for Requip (ropinirole; GlaxoSmithKline) tablets.
The prospect of human stem cells developing in an animal's brain also becomes a possibility, raising serious ethical dilemmas that go to the core of what it is to be human.
For patients with diabetes, statin use is associated with reduced incidence of Parkinson's disease (PD), according to a study published online in the Annals of Neurology.