Pain Management

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

By May 23, 2018

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

Recommendations for Managing Postpartum Pain Published

May 23, 2018

Impact of medications on mother-infant dyad should be considered, as many women breastfeed

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

May 22, 2018

There was a positive correlation for subsequent opioid overdose with successively greater numbers of prescribers or pharmacies or higher opioid quantities during the index period.

IV Tramadol Significantly Reduces Post-Op Pain in Phase 3 Study

By May 21, 2018

In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at hours 0, 2, 4, and once every 4 hours thereafter (up to 13 doses).

AUA: Many Have Unused Opioids After Urologic Procedures

May 21, 2018

The highest percentage of unused medications (70%) was seen for cystectomy, which was the most invasive surgery; the lowest percentage of unused medications was seen for cystoscopy-based procedures (37.5%).

First-of-its-Kind Migraine Drug Gets FDA Approval

By May 18, 2018

The efficacy of Aimovig was evaluated as a preventive treatment of episodic or chronic migraine in 3 randomized, double-blind, placebo-controlled studies: 2 studies in patients with episodic migraine (4-14 migraine days per month) and 1 study in patients with chronic migraine (≥15 headache days per month with ≥8 migraine days per month).

First Non-Opioid Drug Approved for Managing Opioid Withdrawal Symptoms

By May 17, 2018

Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.

Fremanezumab effective in preventing episodic migraine

May 17, 2018

In this randomized controlled trial, Fremanezumab slightly decreased the amount of headache free days in those with episodic migraines compared to placebo.

Fremanezumab Linked to Fewer Monthly Migraine Days

May 16, 2018

The researchers found that over 12 weeks, mean migraine days per month decreased from 8.9 to 4.9 days, from 9.2 to 5.3 days, and from 9.1 to 6.5 days in the fremanezumab monthly dosing group, the fremanezumab single-higher-dose group, and the placebo group, respectively.

Galcanezumab Effective in Phase 3 Episodic Cluster Headache Study

By May 15, 2018

The episodic cluster headache trial included a total of 106 patients with an average of 17.5 cluster headache attacks per week at baseline.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

May 15, 2018

Acetaminophen exposure was protective against postoperative AKI after adjustment for multiple confounding variables (odds ratio, 0.86 per each additional 10mg/kg).

Opioid-Related Payments Linked to Increase in Opioid Rx

May 15, 2018

Researchers examined the extent to which pharmaceutical industry marketing of opioid products to physicians during 2014 correlated with opioid prescribing in 2015.

Practice Intervention Targeting IV Opioids May Cut Exposure

May 14, 2018

"An intervention targeting the use of intravenous opioids may be associated with reduced opioid exposure while providing effective pain control to hospitalized adults," the authors write.

Many Oncologists Discuss, Recommend Medical Marijuana

May 11, 2018

The researchers found that only 30% of oncologists felt sufficiently informed to make recommendations regarding medical marijuana.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

By May 09, 2018

All of these studies, however, had methodological shortcomings (ie, inadequate adjustment for time-invariant; time-varying confounding factors; no adjustment for competing laws/policies that may have affected overdoses).

Marijuana Use Not Linked to Risk of Arrhythmias After Acute MI

May 09, 2018

Overall, 9.7% of both marijuana users and non-users experienced VT/VF or cardiac arrest (P=.94); 4.5 and 8.7%, respectively, experienced atrial fibrillation; and 4 and 6%, respectively, died.

Chronic Aspirin Exposure Linked to Melanoma Risk in Males

May 09, 2018

After stratification by gender, a significant correlation was seen for aspirin exposure and melanoma diagnosis among males (adjusted relative risk, 1.83; 95% confidence interval, 1.22 to 2.76; P=.004), but not females (adjusted relative risk, 0.53; 95% confidence interval, 0.17 to 1.63; P=.266).

Walmart Plans on Restricting Supply on Acute Opioid Prescription Fills

By May 08, 2018

For states that currently limit new acute opioid prescription fills to <7 days, Walmart and Sam's Club pharmacies will follow that state law.

Antipyretic Medications

May 07, 2018

Antipyretics Medications Chart

Antidepressant Medications and Headache: Is There a Link?

By May 03, 2018

Compared to placebo, selective serotonin reuptake inhibitors (SSRIs) were associated with a significantly higher risk of headache (risk ratio [RR] 1.06, 95% CI: 1.00 to 1.13; P =.045).

Atropine plus propofol similar to atropine plus atracurium and sufentanil for non-emergent intubation in neonates

May 03, 2018

In this randomized controlled trial, the frequency of prolonged desaturation during neonatal, nonemergent intubation was similar between atropine plus propofol compared to atropine plus atracurium and sufentanil.

Opioids Often Overprescribed After Hiatal Hernia Surgery

May 03, 2018

Patients use fewer opioids than are prescribed after open, laparoscopic hiatal hernia repair

Anesthesiologists Report Drug Shortages Impacting Patient Care

April 30, 2018

More than 95% of respondents reported that the shortages had an impact on patient care. Hydromorphone, fentanyl, morphine, bupivacaine, and epinephrine were the top drugs listed in short supply.

Results From Phase 3 Trial of Migraine Tx Ubrogepant Released

By April 27, 2018

Results showed that 14.3%, 20.7% (P=.0285), and 21.8% (P=.0129) achieved pain freedom in the placebo, ubrogepant 25mg dose, and 50mg dose groups, respectively.

Multiple Anesthesia Exposures Affect Learning and Attention

April 26, 2018

The researchers found that those with multiple, but not single exposures, had an increased frequency of both learning disabilities and attention-deficit/hyperactivity disorder (hazard ratio for learning disabilities, 2.17) versus unexposed children.

People With Opioid Use Disorder Have High Suicide Rate

April 26, 2018

Based on data from the National Death Index and electronic health records, suicide risk was 87 per 100,000 among persons with OUD, 6 times that of people in the general US population. Efforts should be made to change opioid prescribing practices and to expand treatment for people with OUD.

Ticagrelor &#43; Aspirin Beneficial After Elective CABG

April 25, 2018

The researchers found that the rates of saphenous vein graft patency were 88.7, 82.8, and 76.5%, respectively, with ticagrelor + aspirin, ticagrelor alone, and aspirin alone at one year post-CABG.

Celecoxib Lowers Opioid Use Post Head &amp; Neck Cancer Surgery

April 23, 2018

The researchers observed a correlation for celecoxib treatment in the postoperative setting with decreased mean use of opioids in oral, intravenous (IV), and total amount of morphine equivalents per day.

Adults Using Benzodiazepines More Likely to Receive Opioid Rx

April 20, 2018

Increase in new opioid prescriptions for U.S. adults using benzodiazepines stopped in 2010