Pain Management

Is ED-Initiated Buprenorphine for Opioid Dependence Cost Effective?

By August 16, 2017

Results showed that the mean costs over the next 30 days after ED visits were $1,752, $1,805 and $1,977 for ED-initiated buprenorphine, referral alone and brief intervention with facilitated referral, respectively.

Are OTC Lidocaine Patches as Effective as Rx for Localized Pain?

By August 15, 2017

Study authors sought to compare OTC lidocaine 3.6% with menthol 1.25% patches vs. Rx lidocaine 5% as well as to placebo.

Necessity of Opioid Rx Examined Post-Hernia Repair

August 15, 2017

The researchers found that 85.9% of patients reported using four or fewer opioid tablets, with 59.5% reporting that they used no opioid analgesics postoperatively.

Cannabis Efficacy Examined in Patients with Chronic Pain, PTSD

August 15, 2017

The researchers found low-strength evidence that cannabis alleviates neuropathic pain based on 27 chronic pain trials; insufficient evidence was found in other pain populations.

Severe Rise in Opioid Overdose ICU Admissions From 2009 to 2015

August 14, 2017

There was a 34% increase in opioid overdose admissions requiring intensive care during this time period, from 44 to 59 per 10,000 ICU admissions. The average mortality rate of patients with ICU admissions with overdoses was 7%, but this increased to 10% in 2015.

Opioid Epidemic Declared National Emergency

By August 11, 2017

Among the areas likely to benefit from increased funding are treatment centers, with the White House panel recommending rules be waived so that Medicaid recipients can get treatment for their addictions.

DEA Issues Comprehensive 'Drug Slang' List to Aid in Abuse Identification

August 11, 2017

In light of the plethora of street names used to refer to a number of drugs, the DEA has issued a comprehensive list for common drugs.

Opioids with Abuse Deterrent Properties

August 10, 2017

Compare the abuse deterrent mechanism, special risk groups, contraindications, and warnings/precautions for FDA approved opioids.

Does the FDA's 'Flush List' Pose a Toxic Threat?

By August 10, 2017

The full results, published in Science of The Total Environment, found that even if the entire mass supplied for clinical use was flushed that the release of 10 'flush list' APIs poses a 'negligible' eco-toxicological risk (including buprenorphine, diazepam, fentanyl, hydromorphone, meperidine, methadone, methylphenidate, morphine, oxycodone, tapentadol).

Marijuana Use May Increase Risk of Death from Hypertension

August 10, 2017

Over 19,569 person-years of follow-up, the adjusted hazard ratios for death from hypertension among marijuana users was 3.42 (95% confidence interval, 1.20 to 9.79).

Opioid Prescribing Trends Among Cancer Survivors

August 10, 2017

Significantly higher prescribing rates were seen in individuals from lower income quintiles, who were younger, who were from rural neighborhoods, and who had a greater number of comorbidities.

Interactions Identified Between Cannabidiol, Antiepileptic Drugs

August 08, 2017

The researchers observed significant increases in topiramate, rufinamide, and N-desmethylclobazam and a significant decrease in clobazam serum levels with increasing cannabidiol dose.

Migraine and Headache Treatments

August 08, 2017

Adult doses for migraine and headache treatments including barbiturates, ergot alkaloids, and NSAIDs.

Narcotic Analgesics

August 08, 2017

A comparative chart of narcotic analgesics including formulations, strengths, and dosing intervals.

Investigational Migraine Drug Lasmiditan Effective in Phase 3 Study

By August 04, 2017

Results showed that a statistically significant number of those participants who received lasmiditan (in all doses) were pain-free at 2-hours post dosage compared to those who received placebo (the primary endpoint).

DEA Proposes Cut in Controlled Substance Manufacturing for 2018

By August 04, 2017

The DEA's manufacturing reduction applies to commonly prescribed Schedule II opioids.

Study Suggests 'Reservoir' of Unused Rx Opioids in U.S.

August 04, 2017

Researchers found that between 67 and 92% of patients reported unused opioids (42 to 71% of all the opioid tablets).

Reasons for Buprenorphine Underuse ID'd in Physician Survey

August 04, 2017

The main reasons that physicians with waivers indicated no willingness to increase prescribing were lack of belief in agonist treatment (odds ratio, 3.98), lack of time for additional patients (odds ratio, 5.54), and belief that reimbursement rates are insufficient (odds ratio, 2.50).

FDA Clears Non-Invasive Device to Treat Chronic Intractable Pain

By August 03, 2017

The Stimpod NMS460 includes a nerve-mapping pen-like probe which allows practitioners to locate nerves and evaluate the treatment progress.

Neonatal Drug Withdrawal Risk Up with In Utero Exposure to Opioids, Psychotropics

August 03, 2017

The researchers observed variation in the absolute risk for neonatal drug withdrawal from 1.0 to 11.4% for infants exposed in utero to prescription opioids alone and opioids co-prescribed with gabapentin, respectively.

Sefria Fentanyl Screening Test Gets FDA Clearance

By August 03, 2017

The test has demonstrated cross-reactivity with acetyl fentanyl, butyryl fentanyl, despropionyl fentanyl, and sufentanil.

Clinicians Increasingly Prescribing Gabapentinoids to Avoid Opioids

August 03, 2017

Gabapentinoids are increasingly being used for almost any type of pain. U.S. prescribing data support this, with gabapentin being the 10th most commonly prescribed medication in 2016.

CAM Use Among Migraine/Headache Sufferers Investigated

By August 02, 2017

The use of complementary and alternative medicine (CAM) specifically for the treatment of migraine and headache is "relatively low" in the U.S.

'Smart' Undergarment Helps Reduce Stress on the Lower Back

By August 02, 2017

When wearing the clothing lower back activity was reduced by an average of 15 to 45%.

Study Reports on Prevalence of Rx Opioid Use, Misuse, and Use Disorders

August 02, 2017

Nearly 92 million Americans used legitimately prescribed opioids in 2015, survey shows

Opioid Epidemic Needs to Be Declared a National Emergency, Says Special Commission

By August 01, 2017

The final recommendations - expected in the Fall - if implemented, will ensure that the Federal Government operates as a strong partner in the fight against addiction and the opioid crisis.

Morphine Effects Examined in RA, Chronic Fatigue Syndrome/Fibromyalgia

July 27, 2017

Anti-hyperalgesic effects of morphine also similar to placebo in chronic fatigue/fibromyalgia

Neuropathic Pain Treatments

July 27, 2017

Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.

SAMHSA Evaluate Opioid Abuse Among Over 50s in the U.S.

July 27, 2017

Rates of opioid abuse among young adults - aged 18 to 25 - decreased from 11.5% in 2002 to 8.1% in 2014. But in adults 50 years and older, opioid abuse doubled, from 1.1 to 2.0%

Aimovig for Migraine Prophylaxis Under FDA Review

By July 21, 2017

If approved by the FDA, Aimovig will be the first monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor specifically intended for migraine prophylaxis.