Generic Name for OXYCONTIN
Oxycodone HCl 10mg, 15mg, 20mg, 30mg, 40mg, 60mg, 80mg; controlled-release tabs.
Legal Classification:
CII
Pharmacological Class for OXYCONTIN
Opioid.
Manufacturer of OXYCONTIN
Purdue Pharma L.P.
|
Indications for OXYCONTIN
Moderate to severe pain when continuous opioid analgesia is needed for extended time period. Not for as-needed use.
Adult dose for OXYCONTIN
See literature. Swallow whole. ≥18 years: individualize; usually given on a 12-hour schedule. Opioid-naive: initially 10mg every 12 hours. Converting from other opioids or combinations: see literature. Hepatic dysfunction or concomitant CNS depressants: reduce dose by ⅓ to ½. Use 60mg (and higher) strength, or a single dose >40mg, in opioid-tolerant patients only.
Children's dosing for OXYCONTIN
<18 years: not recommended.
Contraindications for OXYCONTIN
Severe respiratory depression. Acute or severe asthma or hypercarbia. Paralytic ileus.
Warnings/Precautions for OXYCONTIN
Not for post-op use unless previously on OxyContin, or if pain expected to be persistent. Head injury. Increased intracranial pressure. CNS depression. Coma. Toxic psychosis. Convulsive disorders. Shock. Impaired pulmonary, renal, hepatic, thyroid, or adrenocortical function. GI or GU obstruction. Acute abdomen. Biliary tract disease. Acute pancreatitis. Volume depleted. Kyphoscoliosis (associated with respiratory depression). Acute alcoholism. Delirium tremens. Avoid abrupt cessation. Reevaluate periodically. Drug abusers. Elderly. Debilitated. Pregnancy (Cat.B). Labor & delivery, nursing mothers: not recommended.
Interactions for OXYCONTIN
Potentiation with alcohol, other CNS depressants, anticholinergics, MAOIs, tricyclic antidepressants, phenothiazines, general anesthetics, skeletal muscle relaxants. May be potentiated by CYP3A4 or CYP2D6 inhibitors (eg, macrolides, azole antifungals, protease inhibitors, amiodarone, quinidine). May be antagonized by CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin).
Adverse Reactions for OXYCONTIN
Somnolence, constipation, nausea, vomiting, dizziness, pruritus, headache, dry mouth, sweating, asthenia, respiratory depression/arrest, hypotension.
How is OXYCONTIN supplied?
Tabs—100