| ANTICHOLINERGIC |
| Imipramine HCl |
Tofranil
(Mallinckrodt) |
tabs |
10mg, 25mg, 50mg |
<6 years: not recommended.
≥6
years: initially 25mg daily 1 hour before bedtime; after 1 week,
increase to 50mg for children 6–12 years, up to 75mg for those >12 years.
|
Attempt drug-free periods after gradual tapering of dose
if drug response favorable. |
Early night bedwetters: give 25mg in
afternoon and repeat at bedtime.
Max 2.5mg/kg per day. |
| ANTISPASMODIC/ANTICHOLINERGIC |
| Darifenacin HBr |
Enablex
(Novartis) |
ext-rel tabs |
7.5mg, 15mg |
Children: not recommended.
Adults: Initially 7.5mg once daily; may increase to 15mg
once daily after 2 weeks. Max 7.5mg once daily in moderate hepatic impairment or
with potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir,
nelfinavir, clarithromycin, nefazadone). |
Swallow whole with liquid. |
| Oxybutynin chloride |
Ditropan
(Ortho-McNeil) |
scored tabs |
5 mg |
<5yrs: not recommended.
≥5yrs: 5mg twice daily; max 15mg/day.
Adults: 5mg 2–3 times a day; max 20mg/day. |
|
| syrup |
5mg/5mL |
Ditropan
XL
(Ortho-McNeil) |
ext-rel tabs |
5mg, 10mg, 15mg |
<6yrs: not recommended.
≥6yrs: Initially 5mg once daily; may increase in 5mg
increments; max 20mg/day.
Adults: Initially 5mg or 10mg
once daily; may increase weekly in 5mg increments; max 30mg/day. |
Swallow whole. Take with fluid. |
Gelnique
(Watson) |
gel |
100mg/g per sachet |
Children: not recommended.
Adults: Apply one sachet once daily to dry, intact skin.
Rotate application sites. |
Apply to abdomen, upper arms/shoulders, or thighs. Application
should not be made to the same site on consecutive days. |
| Solifenacin succinate |
Vesicare
(Astellas) |
tabs |
5mg, 10mg |
Children: not recommended.
Adults: Initially 5mg once daily; if well tolerated, may
increase to 10mg once daily. Severe renal impairment (CrCl<30mL/min),
moderate hepatic impairment, or concomitant potent CYP3A4 inhibitors (eg,
ketoconazole): max 5mg once daily. |
Swallow whole with liquids. |
| Trospium chloride |
Sanctura
(Allergan) |
tabs |
20mg |
Children: not recommended.
Adults: 20mg twice daily. ≥75yrs: 20mg once daily if twice
daily dose not tolerated. Severe renal impairment (CrCl<30mL/min): 20mg once
daily at bedtime. |
Take on empty stomach. |
Sanctura
XR
(Allergan) |
ext-rel caps |
60mg |
Children: not recommended.
Adults: 60mg daily in the AM. Severe renal impairment
(CrCl<30mL/min): not recommended. |
Take on empty stomach. |
| MUSCARINIC ANTAGONIST |
| Fesoterodine fumarate |
Toviaz
(Pfizer) |
ext-rel tabs |
4mg, 8mg |
Children: not recommended.
Adults: Initially 4mg once daily; if well tolerated, may
increase to 8mg once daily. Severe renal impairment (CrCl<30mL/min) or
concomitant potent CYP3A4 inhibitors (eg, ketoconazole): max 4mg once
daily. |
Swallow whole with liquids. |
| Tolterodine tartrate |
Detrol
(Pfizer) |
tabs |
1mg, 2mg |
Children: not recommended.
Adults: 2mg twice daily; may decrease to 1mg twice daily.
Concomitant CYP3A4 inhibitors, or significant renal or hepatic dysfunction: 1mg
twice daily. |
|
Detrol
LA
(Pfizer) |
ext-rel caps |
2mg, 4mg |
Children: not recommended.
Adults: 4mg once daily; may decrease to 2mg once daily.
Concomitant CYP3A4 inhibitors, or significant renal or hepatic dysfunction: 2mg
once daily. |
Swallow whole. |
| VASOPRESSIN (SYNTHETIC) |
| Desmopressin acetate |
DDAVP
(sanofi aventis) |
scored tabs |
0.1mg, 0.2mg |
<6yrs: not recommended.
6–17yrs: initially 0.2mg once daily at bedtime;
individualize; max 0.6mg. |
When switching to tabs give 1st oral dose 24hrs after last
intranasal dose. |
DDAVP
NASAL SPRAY
(sanofi aventis) |
nasal spray |
10micrograms/spray |
<6yrs: not recommended.
≥6yrs: initially 20micrograms (2 sprays) or 0.2mL soln
intranasally at bedtime. Usual range 10–40micrograms/day at bedtime. Give ½
total dose in each nostril.
Adults: 10–40 micrograms
intranasally at bedtime. |
Use rhinal tube for doses <10micrograms. |
DDAVP
RHINAL TUBE
(sanofi aventis) |
intranasal soln |
10micrograms/0.1mL |
|