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Menopause and HRT
Only 4 drugs may be compared at once

Generic Name and Formulations:

Ortho-Est .625 (estropipate 0.75mg), Ortho-Est 1.25 (estropipate 1.5mg); scored tabs.

Select therapeutic use:

Indications for ORTHO-EST:

Moderate to severe vasomotor symptoms of menopause. Atrophic vaginitis. Kraurosis vulvae. Osteoporosis prevention. Hypoestrogenism.


Menopause, atrophic vaginitis: 0.75–6mg (as estropipate) daily, give cyclically (3 weeks on, 1 week off). Osteoporosis prevention: 0.75mg (as estropipate) daily, give cyclically (25 days of a 31-day cycle). Hypoestrogenism: 1.5mg–9mg (as estropipate) daily for 3 weeks, given cyclically (3 weeks on, 8–10 days off). See literature. Reevaluate periodically.


Not applicable.


Breast or estrogen-dependent carcinoma. Undiagnosed abnormal genital bleeding. Thromboembolic disorders. Thrombophlebitis. Pregnancy (Cat.X).


Patients with an intact uterus should almost always receive a progestin to avoid endometrial hyperplasia. Conditions aggravated by fluid retention. Hepatic dysfunction. Bone disease associated with hypercalcemia. Do initial complete physical and repeat annually (include BP, mammogram, and Pap smear). Discontinue if jaundice or hypertension occurs. Nursing mothers.

Pharmacological Class:


Adverse Reactions:

See literature. Increased risk of thromboembolic disorders, gallbladder disease. GI upset, breakthrough bleeding, edema, weight changes, mastodynia, hypertension, intolerance to contact lenses.

How Supplied: