Oral Therapy for UTIs in Adults
| ORAL THERAPY FOR UTIs IN ADULTS | |||||
|---|---|---|---|---|---|
| Generic | Brand and Manufacturer | Formulation | Strength | Dose | Duration |
| CEPHALOSPORINS | |||||
| Cefadroxil | (various) | caps | 500mg | 1–2g once daily or in 2 divided doses.
Complicated: 2g/day in 2 divided doses |
|
| tabs | 1g | ||||
| susp | 250mg/5mL, 500mg/5mL | ||||
| Cefixime | Suprax
(Lupin) |
tabs | 400mg | 400mg once daily or 200mg every 12 hrs | |
| susp | 100mg/5mL, 200mg/5mL | ||||
| Cefpodoxime | (various) | granules for susp | 50mg/5mL, 100mg/5mL | 100mg every 12 hrs | 7 days |
| tabs | 100mg, 200mg | ||||
| Cefuroxime | Ceftin
(GlaxoSmithKline) |
tabs | 250mg, 500mg | 250mg twice daily | 7–10 days |
| Cephalexin | Keflex
(Shionogi) |
caps | 250mg, 500mg, 750mg | Uncomplicated cystitis: 500mg every 12 hours; max 4g/day | 7–14 days |
| NITROFURANTOINS | |||||
| Nitrofurantoin | Furadantin
(Shionogi) |
susp | 25mg/5mL | 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice |
|
| Macrobid
(Warner Chilcott) |
caps | 100mg | 100mg every 12 hours | 7 days | |
| Macrodantin
(Warner Chilcott) |
caps | 25mg, 50mg, 100mg | 50–100mg 4 times daily. Long-term use: 50–100mg once daily at bedtime |
7 days | |
| PENICILLINS | |||||
| Amoxicillin | (various) | caps | 250mg, 500mg | 250mg every 8 hours | |
| tabs | 500mg, 875mg | ||||
| susp | 125mg/5mL, 250mg/5mL | ||||
| Amoxicillin + Clavulanic acid (clavulanic acid component in parenthesis) |
Augmentin
(Dr. Reddy's Laboratories) |
tabs | 250mg (125mg), 500mg (125mg), 875mg (125mg) | 500mg every 12 hours or 250mg every 8 hours | |
| susp | 125mg (31.25mg)/5mL, 200mg (28.5mg)/5mL, 250mg (62.5mg)/5mL, 400mg (57mg)/5mL | ||||
| chewable | 125mg (31.25mg), 200mg (28.5mg), 250mg (62.5mg), 400mg (57mg) | ||||
| QUINOLONES | |||||
| Ciprofloxacin | Cipro
(Bayer) |
tabs | 250mg, 500mg, 750mg | Acute uncomplicated cystitis due to E. coli,
S. saprophyticus in females: 250mg every 12 hours.
Other UTIs: 250–500mg every 12 hours |
3 days (acute uncomplicated cystitis)
7–14 days (other UTIs) |
| susp | 250mg/5mL, 500mg/5mL | ||||
| Ciprofloxacin ext-rel | Cipro XR
(Bayer) |
tabs | 500mg, 1g | Uncomplicated UTI: 500mg once daily | 3 days |
| Complicated UTI, acute uncomplicated pyelonephritis: 1000mg once daily | 7–14 days | ||||
| Levofloxacin | Levaquin
(Janssen) |
soln | 25mg/mL | Uncomplicated UTIs: 250mg once daily
Complicated UTIs, acute pyelonephritis: 250mg once daily or 750mg once daily |
3 days (uncomplicated UTIs) |
| 10 days (250mg dose for complicated UTIs, acute pyelonephritis) | |||||
| tabs | 250mg, 500mg, 750mg | 5 days (750mg dose for complicated UTIs, acute pyelonephritis) | |||
| Norfloxacin | Noroxin
(Merck) |
tabs | 400mg | Uncomplicated UTI: 400mg every 12 hours for 3 days | 3 days (E. coli, K. pneumoniae, or P. mirabilis); 7–10 days (others) |
| Complicated UTI: 400mg every 12 hours | 10–21 days | ||||
| Ofloxacin | (various) | tabs | 200mg, 300mg, 400mg | Uncomplicated cystitis: 200mg every 12 hours | 3 days (E. coli or K. pneumoniae); 7 days (other) |
| Complicated: 200mg every 12 hours | 10 days | ||||
| SULFONAMIDES | |||||
| Sulfamethoxazole + trimethoprim | (various) | susp | 200mg (SMX) + 40mg (TMP)/5mL | 20mL every 12 hours | 10–14 days |
| Bactrim
(AR Scientific) |
tabs | 400mg (SMX) + 80mg (TMP) | 2 tablets every 12 hours | ||
| Septra
(King) |
|||||
| Bactrim DS
(AR Scientific) |
tabs | 800mg (SMX) + 160mg (TMP) | 1 tablet every 12 hours | ||
| Septra DS
(King) |
|||||
| OTHER CLASSES | |||||
| Fosfomycin | Monurol
(Forest) |
granules for solution | 3g | Mix contents of 1 sachet (3g) with 3–4oz of water (do not use hot water); drink immediately; max 1 dose/episode | 1 dose |
| Trimethoprim | Primsol
(FSC Pediatrics) |
soln | 50mg/5mL | 100mg twice daily, or 200mg once daily | 10 days |
| (various) | tabs | 100mg, 200mg | |||
|
(Rev. 3/2013) |
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